Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053312321> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W2053312321 abstract "Based on the hypothesis of Goldie and Coldman, rapid cyclic alternating chemotherapy has been supposed to be a favorable treatment modality in small cell lung cancer. This approach has been tested in a large series of trials since the late 70's. A few trials performed randomization between alternating and continuous treatment after a period of initial common continuous therapy. The results of these studies are controversial and their interpretation is complicated by the effects of the continuous pretreatment. Recently, most trials were designed as 2-arm approaches with a comparison of continuous standard therapy based on the CAV- or CMC-protocol with an alternating schedule often consisting of the CAV- or CMC-derived combinations and a second regimen including cisplatinum and/or etoposide. In these trials the addition of the second regimen in the alternating treatment arms has improved the treatment results. However, these trials could not clarify whether this advantage was due to the concept of alternating treatment or to the high activity of new drugs given early in the course of therapy in the alternating treatment arms. To ameliorate this weakness, 3 studies were designed as 3-arms approaches using both alternating protocols as continuous control arms. Whereas one investigation noticed an advantage of the alternating schedule, the two others observed no difference. These studies did not report their criteria for shifting non-responding patients from continuous treatment to second line therapy. The longer these patients stayed on the continuous protocol the more the study design favoured the alternating therapy.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2053312321 created "2016-06-24" @default.
- W2053312321 creator A5026379611 @default.
- W2053312321 creator A5043020345 @default.
- W2053312321 date "1990-01-01" @default.
- W2053312321 modified "2023-09-27" @default.
- W2053312321 title "Alternating Chemotherapy in Small Cell Lung Cancer" @default.
- W2053312321 doi "https://doi.org/10.1159/000216751" @default.
- W2053312321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2168532" @default.
- W2053312321 hasPublicationYear "1990" @default.
- W2053312321 type Work @default.
- W2053312321 sameAs 2053312321 @default.
- W2053312321 citedByCount "5" @default.
- W2053312321 crossrefType "journal-article" @default.
- W2053312321 hasAuthorship W2053312321A5026379611 @default.
- W2053312321 hasAuthorship W2053312321A5043020345 @default.
- W2053312321 hasConcept C126322002 @default.
- W2053312321 hasConcept C141071460 @default.
- W2053312321 hasConcept C143998085 @default.
- W2053312321 hasConcept C204243189 @default.
- W2053312321 hasConcept C2776694085 @default.
- W2053312321 hasConcept C2778119113 @default.
- W2053312321 hasConcept C2781413609 @default.
- W2053312321 hasConcept C3018112808 @default.
- W2053312321 hasConcept C535046627 @default.
- W2053312321 hasConcept C71924100 @default.
- W2053312321 hasConceptScore W2053312321C126322002 @default.
- W2053312321 hasConceptScore W2053312321C141071460 @default.
- W2053312321 hasConceptScore W2053312321C143998085 @default.
- W2053312321 hasConceptScore W2053312321C204243189 @default.
- W2053312321 hasConceptScore W2053312321C2776694085 @default.
- W2053312321 hasConceptScore W2053312321C2778119113 @default.
- W2053312321 hasConceptScore W2053312321C2781413609 @default.
- W2053312321 hasConceptScore W2053312321C3018112808 @default.
- W2053312321 hasConceptScore W2053312321C535046627 @default.
- W2053312321 hasConceptScore W2053312321C71924100 @default.
- W2053312321 hasLocation W20533123211 @default.
- W2053312321 hasLocation W20533123212 @default.
- W2053312321 hasOpenAccess W2053312321 @default.
- W2053312321 hasPrimaryLocation W20533123211 @default.
- W2053312321 hasRelatedWork W1904016001 @default.
- W2053312321 hasRelatedWork W1966513127 @default.
- W2053312321 hasRelatedWork W2077980843 @default.
- W2053312321 hasRelatedWork W2086004237 @default.
- W2053312321 hasRelatedWork W2086955530 @default.
- W2053312321 hasRelatedWork W2091361215 @default.
- W2053312321 hasRelatedWork W2314517044 @default.
- W2053312321 hasRelatedWork W2387113950 @default.
- W2053312321 hasRelatedWork W2417697013 @default.
- W2053312321 hasRelatedWork W2462006681 @default.
- W2053312321 isParatext "false" @default.
- W2053312321 isRetracted "false" @default.
- W2053312321 magId "2053312321" @default.
- W2053312321 workType "article" @default.