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- W2053320002 abstract "Protein misfolding is an intrinsic aspect of normal folding within the complex cellular environment. Its effects are minimized in living system by the action of a range of protective mechanisms including molecular chaperones and quality control systems. According to the current growing research, protein misfolding is a recognized key feature of most neurodegenerative diseases. Extensive biochemical, neuropathological, and genetic evidence suggest that the cerebral accumulation of amyloid fibrils is the central event in the pathogenesis of neurodegenerative disorders. In the first part of this review we have discussed the general course of action of folding and misfolding of the proteins. Later part of this review gives an outline regarding the role of protein misfolding in the molecular and cellular mechanisms in the pathogenesis of Alzheimer's and Parkinson along with their treatment possibilities. Finally, we have mentioned about the recent findings in neurodegenerative diseases." @default.
- W2053320002 created "2016-06-24" @default.
- W2053320002 creator A5014818471 @default.
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- W2053320002 creator A5058304909 @default.
- W2053320002 creator A5063051131 @default.
- W2053320002 creator A5063242045 @default.
- W2053320002 date "2014-03-01" @default.
- W2053320002 modified "2023-10-05" @default.
- W2053320002 title "Protein folding and misfolding in the neurodegenerative disorders: A review" @default.
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- W2053320002 doi "https://doi.org/10.1016/j.neurol.2013.11.002" @default.
- W2053320002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24613386" @default.
- W2053320002 hasPublicationYear "2014" @default.
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