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• W2053337121 abstract "In the course of serial coagulation studies on patients with acute leukaemia, defibrination was frequently encountered in the lymphoblastic, myeloblastic and promyelocytic varieties of the disease. Factor-VIII levels were often high and varied very considerably, a particular phenomenon being the association at times of very high one-stage levels with decreased two-stage levels. In one patient heparin infusion was associated with a rise in the two-stage Factor-VIII level and cessation of the infusion with a prompt drop in level. Less frequently, gross elevation of one-stage Factor-XI activity occurred compared with two-stage (eluate test) levels. In order to study possible mechanisms for the phenomena observed, the effect of adding various pro-coagulants to normal plasma on the one- and two-stage methods for measuring Factors VIII, IX and XI was studied. Thrombin caused a marked rise in one-stage Factor-VIII activity and a much smaller rise in one-stage Factor IX and XI measurements. Two-stage Factor-VIII activity was reduced and Factors IX and XI little affected. These findings simulate some of the findings in vivo. The effect of activated Factors IX, X and XI on the one-stage activity of Factors VIII, IX and XI may be explained by assuming that an activated product increases the one-stage activity of any factor which participates in the clotting reaction sequence at a stage preceding the formation of the product. The actual findings were that an activated Factor-X preparation increased one-stage Factors VIII, IX and XI measurements; an activated Factor-IX preparation considerably increased one-stage Factor IX and XI measurements but affected Factor-VIII activity only when used at very high concentrations; an activated Factor-XI preparation did not affect Factor VIII, IX or XI one-stage activity. None of these three activated products influenced the two-stage measurements of Factors VIII, IX and XI. Tissue thromboplastin increased one-stage Factor VIII, IX and XI activity to a similar extent, did not influence two-stage Factor VIII and IX measurements and slightly increased two-stage Factor-XI activity." @default.
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• W2053337121 date "1969-04-01" @default.
• W2053337121 modified "2023-10-18" @default.
• W2053337121 title "Activated Coagulation Factors: In-Vivo and in-Vitro Studies" @default.
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• W2053337121 doi "https://doi.org/10.1111/j.1365-2141.1969.tb00411.x" @default.
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