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- W2053338618 abstract "One of the two major endocannabinoids, 2-arachidonoylglycerol (2-AG), serves as a retrograde messenger at various types of synapses throughout the brain. Upon postsynaptic activation, 2-AG is released immediately after de novo synthesis, activates presynaptic CB1 cannabinoid receptors, and transiently suppresses neurotransmitter release. When CB1 receptor activation is combined with some other factors such as presynaptic activity, the suppression is converted to a long-lasting form. Whereas 2-AG primarily transmits a rapid, transient, point-to-point retrograde signal, the other major endocannabinoid, anandamide, may function as a relatively slow retrograde or non-retrograde signal or as an agonist of the vanilloid receptor. The endocannabinoid system can be up- or down-regulated by a variety of physiological and environmental factors including stress, which might be clinically important." @default.
- W2053338618 created "2016-06-24" @default.
- W2053338618 creator A5072607053 @default.
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- W2053338618 date "2014-12-01" @default.
- W2053338618 modified "2023-09-30" @default.
- W2053338618 title "Endocannabinoid-mediated retrograde modulation of synaptic transmission" @default.
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- W2053338618 doi "https://doi.org/10.1016/j.conb.2014.03.017" @default.
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