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- W2053346015 abstract "The genes encoding human interleukin-4 (IL-4) and interleukin-13 (IL-13) are located on segment q23-31 of chromosome 5 and encode two multifunctional lymphokines with some common functions. We have cloned 72 kb of human genomic DNA that contain IL-4 and IL-13 and their flanking sequences, and constructed a restriction map of this region. Using Southern analysis, we have shown that IL-13 is located 12 kb 5′ to IL-4 and linked in a ‘tail-to-head’ fashion. We have also determined the complete nucleotide sequence of the DNA fragment (about 4.8 kb) containing IL-13 and its 5′ flanking regulatory region (2.1 kb) with a ‘CpG island’. We identified potential binding sites for a different transcription factors in the 5′ flanking region and in the first intron of IL-13. Comparison of IL-13 and IL-4 revealed considerable similarity in the structural organization of these genes and also many potential binding sites for transcription factors common to both genes: AP1, AP2, AP3, PEA3, HRE, TCF-1, GATA-3 and the interferon-inducible and enhancer elements. These results, along with the similarity in functional activity of IL-4 and IL-13 suggests that their expression may be coregulated." @default.
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- W2053346015 date "1995-04-01" @default.
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- W2053346015 title "Tandem arrangement of human genes for interleukin-4 and interleukin-13: Resemblance in their organization" @default.
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- W2053346015 doi "https://doi.org/10.1016/0378-1119(94)00720-d" @default.
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