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- W2053372713 abstract "Integrin-linked kinase (ILK) is a serine/threonine protein kinase that plays an important role in integrin signaling and cell proliferation. We used Cre recombinase (Cre)- loxP technology to study CNS restricted knock-out of the ilk gene by either Nestin -driven or gfap -driven Cre-mediated recombination. Developmental changes in ilk -excised brain regions are similar to those observed in mice lacking the integrin β1 subunit in the CNS, including defective laminin deposition, abnormal glial morphology, and alterations in granule cell migration. Decreases in 6-bromodeoxyuridine (BrdU) pulse labeling and proliferating cell nuclear antigen expression in the external granule cell layer of the cerebellum demonstrated that proliferation is disrupted in granule cells lacking ILK. Previous studies have shown that laminin-sonic hedgehog (Shh)-induced granule cell precursor (GCP) proliferation is dependent on β1 integrins, several of which bind laminin and interact with ILK through the β1 cytoplasmic domain. Both e x vivo deletion of ilk and a small molecule inhibitor of ILK kinase activity decreased laminin-Shh-induced BrdU labeling in cultured GCPs. Together, these results implicate ILK as a critical effector in a signaling pathway necessary for granule cell proliferation and cerebellar development." @default.
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- W2053372713 date "2006-01-18" @default.
- W2053372713 modified "2023-09-23" @default.
- W2053372713 title "Critical Role of Integrin-Linked Kinase in Granule Cell Precursor Proliferation and Cerebellar Development" @default.
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- W2053372713 doi "https://doi.org/10.1523/jneurosci.1852-05.2006" @default.
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