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- W2053372912 abstract "Background Immunogen development for HIV-1 vaccines can be based on epitope identification of naturally occurring neutralizing antibodies in HIV-1 infected patients. A neutralizing monoclonal antibody, HJ16, was obtained at IRB from a patient recruited at ITM which recognized a new epitope in the CD4bs and neutralized mostly tier 2 strains that were not neutralized by b12[1]. This new CD4bs epitope is not fully characterized yet but could be important for immunogen design. We therefore used a neutralization sensitive virus and after resistance induction compared the resistant and sensitive strains to map important regions for the HJ16 neutralizing activity." @default.
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- W2053372912 date "2011-10-03" @default.
- W2053372912 modified "2023-10-09" @default.
- W2053372912 title "HJ16 induced resistant virus displays rare natural mutation highlighting the conserved nature of this new CD4bs epitope" @default.
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- W2053372912 doi "https://doi.org/10.1186/1742-4690-8-s2-p33" @default.
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