Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053375145> ?p ?o ?g. }
- W2053375145 endingPage "3275" @default.
- W2053375145 startingPage "3271" @default.
- W2053375145 abstract "A partial cDNA that encodes a newly discovered member of the syndecan family of integral membrane proteoglycans, which we have termed syndecan 3, has been isolated from an embryonic chicken limb bud cDNA library. Syndecan 3 is distinct from but structurally related to syndecan and fibroglycan, two previously characterized members of this family of membrane-intercalated proteoglycans. Syndecan 3 contains a cytoplasmic domain potentially associated with the cytoskeleton that is 85% identical in amino acid sequence to the cytoplasmic domain of syndecan. Syndecan 3 also possesses a hydrophobic transmembrane domain and an extracellular domain containing several clustered potential glycosaminoglycan attachment sites. Like syndecan, the ectodomain of syndecan 3 has a single dibasic protease-susceptible site adjacent to the transmembrane domain, which might be involved in shedding the ectodomain from the cell surface. A striking feature of syndecan 3 is an extensive (182 amino acid) threonine, serine, and proline (T+S+P)-rich domain that closely resembles T+S+P-rich regions in several mucin-like proteins in which O-linked oligosaccharides are bound to the threonine and serine residues. Syndecan 3 is expressed in high amounts during a critical phase of chicken limb chondrogenesis in which limb mesenchymal cells condense, round up, and interact with one another before depositing a cartilage matrix. The multiple functional domains of syndecan 3 provide potential sites for mediating the adhesive cell-matrix interactions and cytoskeletal reorganization involved in this critical condensation process." @default.
- W2053375145 created "2016-06-24" @default.
- W2053375145 creator A5015641857 @default.
- W2053375145 creator A5071781087 @default.
- W2053375145 creator A5080833592 @default.
- W2053375145 date "1992-04-15" @default.
- W2053375145 modified "2023-09-27" @default.
- W2053375145 title "Syndecan 3: a member of the syndecan family of membrane-intercalated proteoglycans that is expressed in high amounts at the onset of chicken limb cartilage differentiation." @default.
- W2053375145 cites W1488817529 @default.
- W2053375145 cites W1492473590 @default.
- W2053375145 cites W1496679328 @default.
- W2053375145 cites W1505216941 @default.
- W2053375145 cites W1517564457 @default.
- W2053375145 cites W1521949639 @default.
- W2053375145 cites W1548863075 @default.
- W2053375145 cites W1561727975 @default.
- W2053375145 cites W1573490865 @default.
- W2053375145 cites W1586489547 @default.
- W2053375145 cites W1589462468 @default.
- W2053375145 cites W1595402802 @default.
- W2053375145 cites W1608912555 @default.
- W2053375145 cites W1796612477 @default.
- W2053375145 cites W1982635439 @default.
- W2053375145 cites W1984977043 @default.
- W2053375145 cites W1986176372 @default.
- W2053375145 cites W1992486637 @default.
- W2053375145 cites W2002468752 @default.
- W2053375145 cites W2004687677 @default.
- W2053375145 cites W2005546345 @default.
- W2053375145 cites W2009310436 @default.
- W2053375145 cites W2009598071 @default.
- W2053375145 cites W2017627341 @default.
- W2053375145 cites W2017786515 @default.
- W2053375145 cites W2018787027 @default.
- W2053375145 cites W2024144069 @default.
- W2053375145 cites W2028253988 @default.
- W2053375145 cites W2031170198 @default.
- W2053375145 cites W2036663611 @default.
- W2053375145 cites W2036832507 @default.
- W2053375145 cites W2042320391 @default.
- W2053375145 cites W2043884795 @default.
- W2053375145 cites W2049301183 @default.
- W2053375145 cites W2060333964 @default.
- W2053375145 cites W2064724355 @default.
- W2053375145 cites W2080353257 @default.
- W2053375145 cites W2082091542 @default.
- W2053375145 cites W2095734305 @default.
- W2053375145 cites W2138754781 @default.
- W2053375145 cites W2156899368 @default.
- W2053375145 cites W2405397995 @default.
- W2053375145 cites W2414901253 @default.
- W2053375145 doi "https://doi.org/10.1073/pnas.89.8.3271" @default.
- W2053375145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/48848" @default.
- W2053375145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1565618" @default.
- W2053375145 hasPublicationYear "1992" @default.
- W2053375145 type Work @default.
- W2053375145 sameAs 2053375145 @default.
- W2053375145 citedByCount "136" @default.
- W2053375145 countsByYear W20533751452012 @default.
- W2053375145 countsByYear W20533751452013 @default.
- W2053375145 countsByYear W20533751452014 @default.
- W2053375145 countsByYear W20533751452015 @default.
- W2053375145 countsByYear W20533751452016 @default.
- W2053375145 countsByYear W20533751452019 @default.
- W2053375145 countsByYear W20533751452020 @default.
- W2053375145 countsByYear W20533751452021 @default.
- W2053375145 countsByYear W20533751452022 @default.
- W2053375145 countsByYear W20533751452023 @default.
- W2053375145 crossrefType "journal-article" @default.
- W2053375145 hasAuthorship W2053375145A5015641857 @default.
- W2053375145 hasAuthorship W2053375145A5071781087 @default.
- W2053375145 hasAuthorship W2053375145A5080833592 @default.
- W2053375145 hasBestOaLocation W20533751452 @default.
- W2053375145 hasConcept C1009742 @default.
- W2053375145 hasConcept C104317684 @default.
- W2053375145 hasConcept C118892022 @default.
- W2053375145 hasConcept C142669718 @default.
- W2053375145 hasConcept C1491633281 @default.
- W2053375145 hasConcept C167625842 @default.
- W2053375145 hasConcept C170493617 @default.
- W2053375145 hasConcept C189165786 @default.
- W2053375145 hasConcept C24530287 @default.
- W2053375145 hasConcept C2779335624 @default.
- W2053375145 hasConcept C515207424 @default.
- W2053375145 hasConcept C55493867 @default.
- W2053375145 hasConcept C65001120 @default.
- W2053375145 hasConcept C86803240 @default.
- W2053375145 hasConcept C95444343 @default.
- W2053375145 hasConceptScore W2053375145C1009742 @default.
- W2053375145 hasConceptScore W2053375145C104317684 @default.
- W2053375145 hasConceptScore W2053375145C118892022 @default.
- W2053375145 hasConceptScore W2053375145C142669718 @default.
- W2053375145 hasConceptScore W2053375145C1491633281 @default.
- W2053375145 hasConceptScore W2053375145C167625842 @default.
- W2053375145 hasConceptScore W2053375145C170493617 @default.
- W2053375145 hasConceptScore W2053375145C189165786 @default.
- W2053375145 hasConceptScore W2053375145C24530287 @default.
- W2053375145 hasConceptScore W2053375145C2779335624 @default.