FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053403755> ?p ?o ?g. }

• W2053403755 endingPage "1109" @default.
• W2053403755 startingPage "1096" @default.
• W2053403755 abstract "Neuroglobin (NGB) is considered as an endogenous neuroprotective molecule against stroke, since the protein alleviates the adverse effects of hypoxic and ischemic insults. We previously demonstrated the functional link between NGB and mitochondria since it is required for respiratory chain function. Thus, here, we evaluated the relevance of this effect in the Harlequin (Hq) mouse strain, which exhibits retinal ganglion cell (RGC) loss and optic atrophy due to a respiratory chain complex I (CI) defect. A twofold decrease of NGB amounts was observed in Hq retinas. We constructed a recombinant adeno-associated virus which combines to the mouse NGB open reading frame, its 5′ and 3′UTR, for guarantying mRNA stability and translation capacity. The vector was administrated intravitreally to Hq mice and NGB expression was stable for up to 7 months without negative effect on retinal architecture or function. On the contrary, RGCs and their axons were substantially preserved from degeneration; consequently, CI activity in optic nerves was protected conferring improvements in vision. Hence, we established that NGB prevents respiratory chain impairment, therefore, protecting visual function otherwise compromised by mitochondrial energetic failure. Neuroglobin (NGB) is considered as an endogenous neuroprotective molecule against stroke, since the protein alleviates the adverse effects of hypoxic and ischemic insults. We previously demonstrated the functional link between NGB and mitochondria since it is required for respiratory chain function. Thus, here, we evaluated the relevance of this effect in the Harlequin (Hq) mouse strain, which exhibits retinal ganglion cell (RGC) loss and optic atrophy due to a respiratory chain complex I (CI) defect. A twofold decrease of NGB amounts was observed in Hq retinas. We constructed a recombinant adeno-associated virus which combines to the mouse NGB open reading frame, its 5′ and 3′UTR, for guarantying mRNA stability and translation capacity. The vector was administrated intravitreally to Hq mice and NGB expression was stable for up to 7 months without negative effect on retinal architecture or function. On the contrary, RGCs and their axons were substantially preserved from degeneration; consequently, CI activity in optic nerves was protected conferring improvements in vision. Hence, we established that NGB prevents respiratory chain impairment, therefore, protecting visual function otherwise compromised by mitochondrial energetic failure." @default.
• W2053403755 created "2016-06-24" @default.
• W2053403755 creator A5009156340 @default.
• W2053403755 creator A5009651149 @default.
• W2053403755 creator A5013370867 @default.
• W2053403755 creator A5017341201 @default.
• W2053403755 creator A5020813130 @default.
• W2053403755 creator A5021723156 @default.
• W2053403755 creator A5031644553 @default.
• W2053403755 creator A5071307640 @default.
• W2053403755 creator A5073616887 @default.
• W2053403755 creator A5083982156 @default.
• W2053403755 date "2014-06-01" @default.
• W2053403755 modified "2023-09-30" @default.
• W2053403755 title "Neuroglobin Gene Therapy Prevents Optic Atrophy and Preserves Durably Visual Function in Harlequin Mice" @default.
• W2053403755 cites W1511080928 @default.
• W2053403755 cites W1653986885 @default.
• W2053403755 cites W175196754 @default.
• W2053403755 cites W1893444436 @default.
• W2053403755 cites W1965680695 @default.
• W2053403755 cites W1971214182 @default.
• W2053403755 cites W1972016979 @default.
• W2053403755 cites W1973925468 @default.
• W2053403755 cites W1978563483 @default.
• W2053403755 cites W1991547707 @default.
• W2053403755 cites W1994834020 @default.
• W2053403755 cites W1996031113 @default.
• W2053403755 cites W1998130034 @default.
• W2053403755 cites W1999365156 @default.
• W2053403755 cites W2001325871 @default.
• W2053403755 cites W2003895213 @default.
• W2053403755 cites W2011380876 @default.
• W2053403755 cites W2014947131 @default.
• W2053403755 cites W2015664814 @default.
• W2053403755 cites W2017638920 @default.
• W2053403755 cites W2017928361 @default.
• W2053403755 cites W2019767562 @default.
• W2053403755 cites W2029353527 @default.
• W2053403755 cites W2030845029 @default.
• W2053403755 cites W2031990165 @default.
• W2053403755 cites W2032413974 @default.
• W2053403755 cites W2034677778 @default.
• W2053403755 cites W2038813685 @default.
• W2053403755 cites W2039127036 @default.
• W2053403755 cites W2044372603 @default.
• W2053403755 cites W2048144714 @default.
• W2053403755 cites W2054947871 @default.
• W2053403755 cites W2055820698 @default.
• W2053403755 cites W2059819377 @default.
• W2053403755 cites W2064111855 @default.
• W2053403755 cites W2073341982 @default.
• W2053403755 cites W2073344703 @default.
• W2053403755 cites W2083416621 @default.
• W2053403755 cites W2085976704 @default.
• W2053403755 cites W2092061363 @default.
• W2053403755 cites W2095566500 @default.
• W2053403755 cites W2103271167 @default.
• W2053403755 cites W2108656011 @default.
• W2053403755 cites W2118069647 @default.
• W2053403755 cites W2122730881 @default.
• W2053403755 cites W2126978393 @default.
• W2053403755 cites W2130343266 @default.
• W2053403755 cites W2143149723 @default.
• W2053403755 cites W2155377690 @default.
• W2053403755 cites W2157581582 @default.
• W2053403755 cites W2165064737 @default.
• W2053403755 cites W2167058119 @default.
• W2053403755 doi "https://doi.org/10.1038/mt.2014.44" @default.
• W2053403755 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4048897" @default.
• W2053403755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24622090" @default.
• W2053403755 hasPublicationYear "2014" @default.
• W2053403755 type Work @default.
• W2053403755 sameAs 2053403755 @default.
• W2053403755 citedByCount "27" @default.
• W2053403755 countsByYear W20534037552014 @default.
• W2053403755 countsByYear W20534037552015 @default.
• W2053403755 countsByYear W20534037552016 @default.
• W2053403755 countsByYear W20534037552017 @default.
• W2053403755 countsByYear W20534037552018 @default.
• W2053403755 countsByYear W20534037552019 @default.
• W2053403755 countsByYear W20534037552020 @default.
• W2053403755 countsByYear W20534037552021 @default.
• W2053403755 countsByYear W20534037552022 @default.
• W2053403755 countsByYear W20534037552023 @default.
• W2053403755 crossrefType "journal-article" @default.
• W2053403755 hasAuthorship W2053403755A5009156340 @default.
• W2053403755 hasAuthorship W2053403755A5009651149 @default.
• W2053403755 hasAuthorship W2053403755A5013370867 @default.
• W2053403755 hasAuthorship W2053403755A5017341201 @default.
• W2053403755 hasAuthorship W2053403755A5020813130 @default.
• W2053403755 hasAuthorship W2053403755A5021723156 @default.
• W2053403755 hasAuthorship W2053403755A5031644553 @default.
• W2053403755 hasAuthorship W2053403755A5071307640 @default.
• W2053403755 hasAuthorship W2053403755A5073616887 @default.
• W2053403755 hasAuthorship W2053403755A5083982156 @default.
• W2053403755 hasBestOaLocation W20534037551 @default.
• W2053403755 hasConcept C104317684 @default.
• W2053403755 hasConcept C125996951 @default.

• next