FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053409857> ?p ?o ?g. }

• W2053409857 endingPage "1168" @default.
• W2053409857 startingPage "1166" @default.
• W2053409857 abstract "We report a 71-year old man with coronary artery disease. Complete coronary revascularization was not possible with autologous grafts; therefore, a 4-mm expanded polytetrafluoroethylene graft was implanted that had been seeded preoperatively with autologous vascular endothelial cells. At 9-year follow-up, the patient is asymptomatic and shows a patent graft. We report a 71-year old man with coronary artery disease. Complete coronary revascularization was not possible with autologous grafts; therefore, a 4-mm expanded polytetrafluoroethylene graft was implanted that had been seeded preoperatively with autologous vascular endothelial cells. At 9-year follow-up, the patient is asymptomatic and shows a patent graft. The number of patients who do not have available autologous graft material is increasing [1Laube H.R. Duwe J. Rutsch W. Konertz W. Clinical experience with autologous endothelial cell-seeded polytetrafluorethylene coronary artery bypass grafts.J Thorac Cardiovasc Surg. 2000; 120: 134-141Abstract Full Text Full Text PDF PubMed Scopus (120) Google Scholar]; therefore, alternative conduits are needed. Prosthetic grafts have demonstrated a high risk of thrombosis and low patency rates, despite of systemic anticoagulation or antiplatelet therapy [2Tiwari A. Salacinski H.J. Hamilton G. Seifalian A.M. Tissue engineering of vascular bypass grafts: role of endothelial cell extraction.Eur J Vasc Endovasc Surg. 2001; 21: 193-201Abstract Full Text PDF PubMed Scopus (99) Google Scholar]. To reduce the thrombogenicity of prosthetic conduits, 4-mm expanded polytetrafluoroethylene (ePTFE) grafts were seeded with autologous vascular endothelial cells (AVEC) [1Laube H.R. Duwe J. Rutsch W. Konertz W. Clinical experience with autologous endothelial cell-seeded polytetrafluorethylene coronary artery bypass grafts.J Thorac Cardiovasc Surg. 2000; 120: 134-141Abstract Full Text Full Text PDF PubMed Scopus (120) Google Scholar]. We report the use of an AVEC-seeded ePTFE graft to perform complete revascularization. A 71-year-old man was referred in August 1995 to our hospital for angina pectoris. Cardiac risk factors included smoking, diabetes mellitus type 1, and arterial hypertension. His medical history was significant for inferior myocardial infarction, peripheral arterial vascular disease, chronic obstructive pulmonary disease (COPD), and bilateral postthrombotic syndrome with severe varicosis. Transthoracic echocardiography showed a normal left ventricular ejection fraction with inferior akinesia. Coronary angiography revealed significant stenosis in the left main coronary artery, left anterior descending artery, circumflex artery, and chronic occlusion of the right coronary artery. Owing to the absence of autologous venous vessels and a positive Allen test bilaterally, the informed patient was enrolled in our protocol on AVEC-seeded grafts, which was approved by local Ethics Committee. Graft preparation was previously reported [1Laube H.R. Duwe J. Rutsch W. Konertz W. Clinical experience with autologous endothelial cell-seeded polytetrafluorethylene coronary artery bypass grafts.J Thorac Cardiovasc Surg. 2000; 120: 134-141Abstract Full Text Full Text PDF PubMed Scopus (120) Google Scholar]. Briefly, AVEC were harvested from a cutaneous vein in the forearm using 0.2% collagenase P (Boehringer, Ridgefield, CT). Cells were cultured in Dulbecco’s modified Eagle’s medium (Sigma, St Louis, MO) enriched with 20% autologous serum and human recombinant basic fibroblast growth factor. After 5 weeks, enough AVEC were available to seed the luminal surface of a 4-mm ePTFE (Gore-Tex, W. L. Gore & Associates, Flagstaff, AZ) precoated with a modified Tissuecol solution (Baxter, Unterschleissheim, Germany). Electronic microscopy confirmed the adherence of AVEC to the luminal wall. Coronary artery bypass grafting (CABG) was performed according to institutional protocols. The left internal mammary artery (IMA) was placed to the left anterior descending artery, and the AVEC-seeded ePTFE graft was anastomosed to the obtuse marginal branch and to the ascending aorta with 7-0 and 6-0 polypropylene running sutures by using a “no-touch” suturing technique. The patient’s postoperative period was uneventful, and he was discharged on postoperative day 7 with a regimen of acetylsalicylic acid at 100 mg daily. Follow-up was performed by selective angiography and intravascular ultrasonography 6 and 12 months postoperatively and then annually. Since 2002, the patient’s AVEC-seeded graft has been investigated by using contrast-enhanced multislice computed tomography (CT). The last selective angiography from 2001 showed the patency of AVEC-seeded ePTFE graft (Fig 1) and left IMA. Intravascular ultrasound confirmed the smooth unobstructed luminal surface of the AVEC-seeded ePTFE graft. In 2004, the graft’s patency was demonstrated by multislice CT (Fig 2). Currently, the patient is in New York Heart Association (NYHA) functional class I. In 2005 and 2006, the asymptomatic patient refused further follow-up investigations.Fig 2Multislice computed tomography shows a patent expanded polytetrafluoroethylene graft seeded with autologous vascular endothelial cells (white arrowheads) and patent left internal mammary artery (black arrowheads) after 9 years of follow-up.View Large Image Figure ViewerDownload (PPT) Autologous vessels, particularly the left IMA and saphenous veins, are currently the prime choice for CABG surgery. However, up to 30% of patients lacks suitable veins owing to venous abnormality, poor quality, or previous procedures [2Tiwari A. Salacinski H.J. Hamilton G. Seifalian A.M. Tissue engineering of vascular bypass grafts: role of endothelial cell extraction.Eur J Vasc Endovasc Surg. 2001; 21: 193-201Abstract Full Text PDF PubMed Scopus (99) Google Scholar]. Likewise, the increasing frequency of reoperations restricts the availability of the left IMA. Despite the evolution of myocardial revascularization techniques and the progressive aging of the surgical population, complete revascularization remains a fundamental principle of CABG, increasing the quality of life and long-term survival [3Kleisli T. Cheng W. Jacobs M.J. et al.In the current era, complete revascularization improves survival after coronary artery bypass surgery.J Thorac Cardiovasc Surg. 2005; 129: 1283-1291Abstract Full Text Full Text PDF PubMed Scopus (135) Google Scholar]. To realize a complete revascularization, the use of additional autologous arterial grafts has steadily increased. Nevertheless, their use could be either limited or contraindicated. Because of concerns of sternal infection, dehiscence, and mediastinitis, the right IMA is avoided in elderly, obese, or insulin-dependent diabetic patients [4Kouchoukos N.T. Wareing T.H. Murphy S.F. Pelate C. Marshall Jr, W.G. Risks of bilateral internal mammary artery bypass grafting.Ann Thorac Surg. 1990; 49: 210-219Abstract Full Text PDF PubMed Scopus (292) Google Scholar]. The radial artery is avoided in patients with a positive Allen test, diffuse arteriosclerosis and medial calcification, renal dysfunction, trauma to upper limbs, Raynaud disease, and recent transradial coronary angiography [5Sajja L.R. Mannam G. Pantula N.R. Sompalli S. Role of radial artery graft in coronary artery bypass grafting.Ann Thorac Surg. 2005; 79: 2180-2188Abstract Full Text Full Text PDF PubMed Scopus (25) Google Scholar]. Potential insufficient flow in presence of coronary flow competition and vasospasm are major concerns in the use of gastroepiploic artery. Harvest of the gastroepiploic artery requires a laparotomy, and several abdominal complications have been reported. An upper abdominal malignancy represents an absolute contraindication to gastroepiploic artery harvesting, and intraabdominal adhesion owing to previous abdominal operation could result in prolonged harvesting time and accidental graft injury [6Hirose H. Amano A. Takanashi S. Takahashi A. Coronary artery bypass grafting using the gastroepiploic artery: 1,000 cases.Ann Thorac Surg. 2002; 73: 1371-1379Abstract Full Text Full Text PDF PubMed Scopus (71) Google Scholar]. Complete revascularization is our goal, unless the target coronary arteries are small, severely diseased, or both. In our patient, old age and insulin-dependent diabetes mellitus were contraindications to bilateral IMA usage, and a bilateral positive Allen test recommended that radial artery harvesting be avoided. Bilateral postthrombotic syndrome with severe varicosis made the saphenous veins unsuitable. We avoid the gastroepiploic artery in patients with COPD to prevent any possible interferences of the laparotomy on the weaning from ventilatory support. Therefore, lacking autologous grafts, the possibility of incomplete revascularization was likely. Synthetic conduits were used in CABG with poor results. The mechanisms of failure are the inherent thrombogenicity of artificial polymers and the mismatch between the rigid graft and the elastic host artery, resulting in anastomotic intimal hyperplasia and stenosis [2Tiwari A. Salacinski H.J. Hamilton G. Seifalian A.M. Tissue engineering of vascular bypass grafts: role of endothelial cell extraction.Eur J Vasc Endovasc Surg. 2001; 21: 193-201Abstract Full Text PDF PubMed Scopus (99) Google Scholar]. Seeding the lumen of synthetic grafts with AVEC to create a nonthrombogenic surface was first developed by Herring in 1978 [7Herring M. Gardner A. Glover J. A single-staged technique for seeding vascular grafts with autogenous endothelium.Surgery. 1978; 84: 498-504PubMed Google Scholar]. Since then, AVEC-seeded synthetic grafts, 6 to 7 mm in size, have been successfully used by vascular surgeons in the treatment of peripheral vascular occlusive disease. The results clearly demonstrated that in vitro endothelialization reduces synthetic graft occlusion to a level seen in autologous vein grafts [1Laube H.R. Duwe J. Rutsch W. Konertz W. Clinical experience with autologous endothelial cell-seeded polytetrafluorethylene coronary artery bypass grafts.J Thorac Cardiovasc Surg. 2000; 120: 134-141Abstract Full Text Full Text PDF PubMed Scopus (120) Google Scholar, 2Tiwari A. Salacinski H.J. Hamilton G. Seifalian A.M. Tissue engineering of vascular bypass grafts: role of endothelial cell extraction.Eur J Vasc Endovasc Surg. 2001; 21: 193-201Abstract Full Text PDF PubMed Scopus (99) Google Scholar, 8Deutsch M. Meinhart J. Fischlein T. Preiss P. Zilla P. Clinical autologous in vitro endothelialization of infrainguinal ePTFE grafts in 100 patients: a 9-year experience.Surgery. 1999; 126: 847-855Abstract Full Text Full Text PDF PubMed Scopus (249) Google Scholar]. Encouraged by these results, we realized 4-mm AVEC-seeded ePTFE grafts suitable for CABG, and reported a 90.5% patency rate with a mean follow-up of 27.7 months [1Laube H.R. Duwe J. Rutsch W. Konertz W. Clinical experience with autologous endothelial cell-seeded polytetrafluorethylene coronary artery bypass grafts.J Thorac Cardiovasc Surg. 2000; 120: 134-141Abstract Full Text Full Text PDF PubMed Scopus (120) Google Scholar]. Our patient was the first of our reported series, and after 108 months, the AVEC-seeded graft was patent and the patient was in NYHA functional class I. After 2001, we were able to use multislice CT to conduct noninvasive angiographic evaluations of the AVEC-seeded ePTFE graft. This diagnostic technique showed an accuracy of approximately 90% in the detection of coronary artery disease, and an adequate diagnostic quality in the assessment of coronary artery bypass arterial and venous grafts [9Lembcke A. Hein P.A. Dohmen P.M. et al.Pictorial review: electron beam computed tomography and multislice spiral computed tomography for cardiac imaging.Eur J Radiol. 2006; 57: 356-367Abstract Full Text Full Text PDF PubMed Scopus (16) Google Scholar]. Seeding with AVEC seems to increase the biocompatibility of 4-mm ePTFE grafts, which could represent alternative conduits in patients without autologous grafts. However, the long culture time of AVEC makes them currently an attractive proposition only in elective bypass surgery." @default.
• W2053409857 created "2016-06-24" @default.
• W2053409857 creator A5000127532 @default.
• W2053409857 creator A5005813716 @default.
• W2053409857 creator A5032137373 @default.
• W2053409857 creator A5044661544 @default.
• W2053409857 creator A5066037456 @default.
• W2053409857 creator A5073511412 @default.
• W2053409857 date "2007-03-01" @default.
• W2053409857 modified "2023-10-01" @default.
• W2053409857 title "Aortocoronary Endothelial Cell-Seeded Polytetrafluoroethylene Graft: 9-Year Patency" @default.
• W2053409857 cites W1964925548 @default.
• W2053409857 cites W1965579497 @default.
• W2053409857 cites W1967869101 @default.
• W2053409857 cites W1989036868 @default.
• W2053409857 cites W1995600232 @default.
• W2053409857 cites W2079014491 @default.
• W2053409857 cites W2158962790 @default.
• W2053409857 cites W2165157312 @default.
• W2053409857 doi "https://doi.org/10.1016/j.athoracsur.2006.09.016" @default.
• W2053409857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17307482" @default.
• W2053409857 hasPublicationYear "2007" @default.
• W2053409857 type Work @default.
• W2053409857 sameAs 2053409857 @default.
• W2053409857 citedByCount "16" @default.
• W2053409857 countsByYear W20534098572013 @default.
• W2053409857 countsByYear W20534098572016 @default.
• W2053409857 countsByYear W20534098572017 @default.
• W2053409857 countsByYear W20534098572022 @default.
• W2053409857 crossrefType "journal-article" @default.
• W2053409857 hasAuthorship W2053409857A5000127532 @default.
• W2053409857 hasAuthorship W2053409857A5005813716 @default.
• W2053409857 hasAuthorship W2053409857A5032137373 @default.
• W2053409857 hasAuthorship W2053409857A5044661544 @default.
• W2053409857 hasAuthorship W2053409857A5066037456 @default.
• W2053409857 hasAuthorship W2053409857A5073511412 @default.
• W2053409857 hasBestOaLocation W20534098571 @default.
• W2053409857 hasConcept C141071460 @default.
• W2053409857 hasConcept C159985019 @default.
• W2053409857 hasConcept C192562407 @default.
• W2053409857 hasConcept C2780557906 @default.
• W2053409857 hasConcept C71924100 @default.
• W2053409857 hasConceptScore W2053409857C141071460 @default.
• W2053409857 hasConceptScore W2053409857C159985019 @default.
• W2053409857 hasConceptScore W2053409857C192562407 @default.
• W2053409857 hasConceptScore W2053409857C2780557906 @default.
• W2053409857 hasConceptScore W2053409857C71924100 @default.
• W2053409857 hasIssue "3" @default.
• W2053409857 hasLocation W20534098571 @default.
• W2053409857 hasLocation W20534098572 @default.
• W2053409857 hasOpenAccess W2053409857 @default.
• W2053409857 hasPrimaryLocation W20534098571 @default.
• W2053409857 hasRelatedWork W113810927 @default.
• W2053409857 hasRelatedWork W1586374228 @default.
• W2053409857 hasRelatedWork W2003938723 @default.
• W2053409857 hasRelatedWork W2047967234 @default.
• W2053409857 hasRelatedWork W2118496982 @default.
• W2053409857 hasRelatedWork W2364998975 @default.
• W2053409857 hasRelatedWork W2369162477 @default.
• W2053409857 hasRelatedWork W2439875401 @default.
• W2053409857 hasRelatedWork W4238867864 @default.
• W2053409857 hasRelatedWork W2525756941 @default.
• W2053409857 hasVolume "83" @default.
• W2053409857 isParatext "false" @default.
• W2053409857 isRetracted "false" @default.
• W2053409857 magId "2053409857" @default.
• W2053409857 workType "article" @default.