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- W2053420088 abstract "Ultrasonic radiation caused a breakdown in α-tocopherol in the liposomal membranes. Some of the radiolabelled 5-14CH3-α-tocopherol had been broken to α-tocopherylquinone (18.7 ± 1.57 %) and to a less polar compound of α-tocopherol (13.1 ± 1.29 %). When α-tocopherol liposomes were incubated overnight the remaining α-tocopherol was 9.32 ± 1.35 %. Use of butylated hydroxytoluene in liposomes or in the incubation medium (outside liposomes) improved recovery of α-tocopherol to some extent. Butylated hydroxytoluene in the liposomal fraction protected 26.8 ± 1.78 % of α-tocopherol, while in the incubation medium (outside the liposome) it protected 37.9 ± 1.18 %. There was a shift from α-tocopherylquinone formation to a less polar compound of α-tocopherol formation when butylated hydroxytoluene was present both in liposome and in the incubation medium; the protection was increased to 53.2 ± 1.61 %. However, ascorbate added to the incubation medium protected 86.4 ± 1.45 % of labeled α-tocopherol. Our findings suggest that ascorbate is a better antioxidant than butylated hydroxytoluene during the preparation of α-tocopherol liposomes." @default.
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- W2053420088 date "1995-06-01" @default.
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- W2053420088 title "Use of antioxidants during preparation of α-tocopherol enriched liposomes" @default.
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- W2053420088 doi "https://doi.org/10.1016/0271-5317(95)00045-k" @default.
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