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• W2053422606 abstract "1 Voluntary intake of various pair combinations of fluids (100 mM, 10 mM LiC1, 10 mM NaC1, water) and body weight was measured daily in rats. 2 More lithium was consumed when water was available. 3 When offered a lithium-sodium choice the rats did not consume significantly more saline than water on the previous trial. While saline consumption increased over the two days, lithium decreased slightly. 4 Following the lithium-only trial, water and saline were provided. Marked polydipsia was observed on the first day and the rats drank more water than saline. On the second day there was a significant drop in saline intake while water consumption returned to baseline levels. 5 Behavioural measurements overall confirmed the depressant effect of lithium: decreased ambulation and rearing and increased time spent immobile/grooming. 6 These findings are discussed with reference to lithium toxicity, which may be a comfounding variable in studies concerned with the effects of this salt on the behavior of laboratory rodents. Behavioural irritability such as aggression reported in situations using long-term lithium treatment may be reduced by provision for voluntary saline consumption." @default.
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• W2053422606 date "1975-11-01" @default.
• W2053422606 modified "2023-09-27" @default.
• W2053422606 title "VOLUNTARY LITHIUM INTAKE, ‘ANTIDOTAL THIRST’ AND CONCURRENT BEHAVIOUR OF RATS" @default.
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• W2053422606 doi "https://doi.org/10.1111/j.1476-5381.1975.tb06945.x" @default.
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