Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053431909> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2053431909 endingPage "S220" @default.
- W2053431909 startingPage "S220" @default.
- W2053431909 abstract "BMPs promote the differentiation of osteoprogenitor cells, and also induce osteogenesis in bone marrow stromal cells (MSCs) from rats and mice. However, compared to results with animal models, BMPs are relatively inefficient in inducing human MSCs to undergo osteogenesis, and are much less effective in promoting bone formation in human clinical trials. Previous studies indicated that, while human MSCs respond to Dex with elevated levels of the osteoblast marker alkaline phosphatase, most isolates of human MSCs fail to show alkaline phosphatase induction in response to BMP-2,|[minus]|4 and |[minus]|7. LIM Mineralization Protein-1 (LMP-1) is an intracellular regulatory protein that can induce the expression of multiple BMPs and promote osteoblast differentiation in vitro and in vivo. The purpose of this study was: 1) To determine if delivery of LMP-1 can increase the responsiveness of human MSCs to BMP-2 as evidenced by increasing osteoblastic markers, and 2) To determine if delivery of LMP-1 can potentiate BMP-2 induction of mineralization by human MSC cultures." @default.
- W2053431909 created "2016-06-24" @default.
- W2053431909 creator A5002847881 @default.
- W2053431909 creator A5007367310 @default.
- W2053431909 creator A5023100003 @default.
- W2053431909 creator A5028728674 @default.
- W2053431909 creator A5034025244 @default.
- W2053431909 creator A5039847195 @default.
- W2053431909 creator A5055151607 @default.
- W2053431909 creator A5057207382 @default.
- W2053431909 date "2006-01-01" @default.
- W2053431909 modified "2023-10-03" @default.
- W2053431909 title "571. Increasing BMP Responsiveness in Human Mesenchymal Stem Cells In-Vitro by Delivery of the Osteoinductive LMP-1 Gene" @default.
- W2053431909 doi "https://doi.org/10.1016/j.ymthe.2006.08.644" @default.
- W2053431909 hasPublicationYear "2006" @default.
- W2053431909 type Work @default.
- W2053431909 sameAs 2053431909 @default.
- W2053431909 citedByCount "0" @default.
- W2053431909 crossrefType "journal-article" @default.
- W2053431909 hasAuthorship W2053431909A5002847881 @default.
- W2053431909 hasAuthorship W2053431909A5007367310 @default.
- W2053431909 hasAuthorship W2053431909A5023100003 @default.
- W2053431909 hasAuthorship W2053431909A5028728674 @default.
- W2053431909 hasAuthorship W2053431909A5034025244 @default.
- W2053431909 hasAuthorship W2053431909A5039847195 @default.
- W2053431909 hasAuthorship W2053431909A5055151607 @default.
- W2053431909 hasAuthorship W2053431909A5057207382 @default.
- W2053431909 hasBestOaLocation W20534319091 @default.
- W2053431909 hasConcept C104317684 @default.
- W2053431909 hasConcept C111599444 @default.
- W2053431909 hasConcept C135983454 @default.
- W2053431909 hasConcept C198826908 @default.
- W2053431909 hasConcept C202751555 @default.
- W2053431909 hasConcept C54355233 @default.
- W2053431909 hasConcept C86803240 @default.
- W2053431909 hasConcept C95444343 @default.
- W2053431909 hasConceptScore W2053431909C104317684 @default.
- W2053431909 hasConceptScore W2053431909C111599444 @default.
- W2053431909 hasConceptScore W2053431909C135983454 @default.
- W2053431909 hasConceptScore W2053431909C198826908 @default.
- W2053431909 hasConceptScore W2053431909C202751555 @default.
- W2053431909 hasConceptScore W2053431909C54355233 @default.
- W2053431909 hasConceptScore W2053431909C86803240 @default.
- W2053431909 hasConceptScore W2053431909C95444343 @default.
- W2053431909 hasLocation W20534319091 @default.
- W2053431909 hasOpenAccess W2053431909 @default.
- W2053431909 hasPrimaryLocation W20534319091 @default.
- W2053431909 hasRelatedWork W2009966535 @default.
- W2053431909 hasRelatedWork W2019988726 @default.
- W2053431909 hasRelatedWork W2021459535 @default.
- W2053431909 hasRelatedWork W2051461989 @default.
- W2053431909 hasRelatedWork W2088063203 @default.
- W2053431909 hasRelatedWork W2171277769 @default.
- W2053431909 hasRelatedWork W2385025331 @default.
- W2053431909 hasRelatedWork W2423871774 @default.
- W2053431909 hasRelatedWork W2921119069 @default.
- W2053431909 hasRelatedWork W3033910563 @default.
- W2053431909 hasVolume "13" @default.
- W2053431909 isParatext "false" @default.
- W2053431909 isRetracted "false" @default.
- W2053431909 magId "2053431909" @default.
- W2053431909 workType "article" @default.