FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053432837> ?p ?o ?g. }

• W2053432837 endingPage "49" @default.
• W2053432837 startingPage "20" @default.
• W2053432837 abstract "Alkaloids cannot be supposed to be waste products of general metabolism. They are formed only for a relatively brief time during the lifespan of the culture and under conditions of reduced proliferation. Living rather than dying cells are required for alkaloid synthesis. The alkaloid yield and differentiated cells were observed to be inversely proportional. This pattern is correlated with formation of secondary shunt products. The district between the cell-pool tryptophan “down” and “up” phases is a promising target for the investigation of regulation of the alkaloid formation and continuous fermentation of these compounds. Considering the general phenomenon of secondary metabolism we may guess that alkaloid formation includes derepression of the appropriate portion of the genome to obtain transcription and translation of specific synthetases and subsequent activity of these enzymes for a relatively brief period. The ability to produce alkaloids is not only easily lost genetically, but is also extraordinarily susceptible to suppression by rather minor environmental manipulations. The production of alkaloids occurs only in nutrient media with high osmotic pressure. Ergoline alkaloids do not definitely belong to a group of physiologically inert secondary metabolites. They are, in fact, able to influence primary shunt metabolism, and may reflect a regulatory device of the producing cell. Alkaloids increase the activities of tryptophan synthetase and acetyl-CoA carboxylase of the ergot fungus and exert a negative effect on citrate synthase, isocitrate lynse, and malate synthase. Also inhibition of Claviceps peptidases by peptide alkaloids is of peculiar interest. Addition of ergometrine (10-4 M) to the submerged culture of C. paspali increased the total-alkaloid yield by 120%. However, the stimulatory effect was inversely proportional to the concentration of the supplied ergometrine. Implicit in these data is that in alkaloid-producing cultures accumulating alkaloids may suppress the attainment of the yield that would be achieved by continuous control of the alkaloid level. Man weiß seit langem, daß im allgemeinen Mutterkornzuchtstämme, die unter parasitischen Bedingungen reichlich Alkaloide bilden, bei der saprophytischen Kultivation keine oder nur in Spuren Ergoline synthetisieren. Die vorliegende Übersicht ist ein Beitrag zur Problematik der Physiologie der Alkaloidbildung bei saprophytischen Claviceps-Arten. Die Mutterkornalkaloide treten nur in bestimmten Entwicklungsstadien der Kultur und unter Bedingungen der reduzierten Proliferation auf. Meistens ist die Alkaloidsynthese mit herabgesetzter Zelldifferenzierung verknüpft. Die Fähigkeit des Stammes, Alkaloide zu bilden, ist stark abhängig vom eingesetzten Medium. Die Schlüsselsubstanz aller Ergoline ist das Tryptophan. Der Abschnitt zwischen der Phase des Absinkens und der Phase des Anstiegs des freien Zelltryptophans ist anscheinend ein vielversprechender Ansatzpunkt für die Steuerung der Alkaloidsynthese und für die kontinuierliche Fermentation der Alkaloide. Die Mutterkornalkaloide beeinflussen einige wichtige Enzyme des primären Stoffwechscls, z. B. stimulieren sie die Tryptophansynthetase und die Acetyl-CoA-Karboxylase und hemmen die Citratsynthetase, Isocitratlyase, Malatsynthetase und die intracellulären Exopeptidasen der Claviceps-Stämme. Nach dem Einsatz von Ergometrin (10-4 M) in die Claviceps-Tiefkultur steigt die Alkaloidausbeute um 120%. Der Effekt hängt von der Menge des zugegebenen Ergometrins ab. Man kann annehmen, daß die Mutterkornalkaloide physiologisch aktive Metabolite darstellen und sich an der Regulation ihrer eigenen Synthese beteiligen." @default.
• W2053432837 created "2016-06-24" @default.
• W2053432837 creator A5022214089 @default.
• W2053432837 date "1974-01-01" @default.
• W2053432837 modified "2023-09-27" @default.
• W2053432837 title "Ergot Alkaloids and Some Problems of the Physiology of Their Formation" @default.
• W2053432837 cites W1222157406 @default.
• W2053432837 cites W1500734065 @default.
• W2053432837 cites W1532972705 @default.
• W2053432837 cites W1571974428 @default.
• W2053432837 cites W1575630534 @default.
• W2053432837 cites W1879302471 @default.
• W2053432837 cites W1966189082 @default.
• W2053432837 cites W1969905421 @default.
• W2053432837 cites W1976660021 @default.
• W2053432837 cites W1979665960 @default.
• W2053432837 cites W1987640967 @default.
• W2053432837 cites W1988750010 @default.
• W2053432837 cites W1988973733 @default.
• W2053432837 cites W1995523432 @default.
• W2053432837 cites W2001781173 @default.
• W2053432837 cites W2002233688 @default.
• W2053432837 cites W2006667801 @default.
• W2053432837 cites W2006708365 @default.
• W2053432837 cites W2009086640 @default.
• W2053432837 cites W2013108825 @default.
• W2053432837 cites W2014737149 @default.
• W2053432837 cites W2022587049 @default.
• W2053432837 cites W2027016050 @default.
• W2053432837 cites W2027437725 @default.
• W2053432837 cites W2034346017 @default.
• W2053432837 cites W2034882374 @default.
• W2053432837 cites W2041651532 @default.
• W2053432837 cites W2044316271 @default.
• W2053432837 cites W2046425294 @default.
• W2053432837 cites W2048398501 @default.
• W2053432837 cites W2051001960 @default.
• W2053432837 cites W2051151584 @default.
• W2053432837 cites W2053514865 @default.
• W2053432837 cites W2053612066 @default.
• W2053432837 cites W2056689484 @default.
• W2053432837 cites W2057610438 @default.
• W2053432837 cites W2059145227 @default.
• W2053432837 cites W2062761569 @default.
• W2053432837 cites W2064457415 @default.
• W2053432837 cites W2067755843 @default.
• W2053432837 cites W2069035868 @default.
• W2053432837 cites W2071412117 @default.
• W2053432837 cites W2073537827 @default.
• W2053432837 cites W2076614187 @default.
• W2053432837 cites W2076805650 @default.
• W2053432837 cites W2079756981 @default.
• W2053432837 cites W2080208251 @default.
• W2053432837 cites W2082679953 @default.
• W2053432837 cites W2083519430 @default.
• W2053432837 cites W2084474122 @default.
• W2053432837 cites W2085058198 @default.
• W2053432837 cites W2090529300 @default.
• W2053432837 cites W2091878954 @default.
• W2053432837 cites W2093465342 @default.
• W2053432837 cites W2098020638 @default.
• W2053432837 cites W2104813542 @default.
• W2053432837 cites W2110009672 @default.
• W2053432837 cites W2160484472 @default.
• W2053432837 cites W2165195834 @default.
• W2053432837 cites W2312247635 @default.
• W2053432837 cites W2312430887 @default.
• W2053432837 cites W2315312008 @default.
• W2053432837 cites W2331039468 @default.
• W2053432837 cites W2335261783 @default.
• W2053432837 cites W2402690588 @default.
• W2053432837 cites W2417668554 @default.
• W2053432837 cites W3165473716 @default.
• W2053432837 cites W3191302407 @default.
• W2053432837 cites W34167007 @default.
• W2053432837 cites W4230910586 @default.
• W2053432837 cites W4235824154 @default.
• W2053432837 cites W4237109402 @default.
• W2053432837 cites W4246828219 @default.
• W2053432837 cites W4252985490 @default.
• W2053432837 cites W4255785220 @default.
• W2053432837 cites W4299736337 @default.
• W2053432837 cites W1759120451 @default.
• W2053432837 cites W2093684869 @default.
• W2053432837 doi "https://doi.org/10.1016/s0044-4057(74)80063-8" @default.
• W2053432837 hasPublicationYear "1974" @default.
• W2053432837 type Work @default.
• W2053432837 sameAs 2053432837 @default.
• W2053432837 citedByCount "1" @default.
• W2053432837 crossrefType "journal-article" @default.
• W2053432837 hasAuthorship W2053432837A5022214089 @default.
• W2053432837 hasConcept C140137476 @default.
• W2053432837 hasConcept C165267168 @default.
• W2053432837 hasConcept C181199279 @default.
• W2053432837 hasConcept C185592680 @default.
• W2053432837 hasConcept C2777135210 @default.
• W2053432837 hasConcept C2777157883 @default.
• W2053432837 hasConcept C2777529992 @default.

• next