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- W2053441330 abstract "Affinity maturation, the fundamental basis for adaptive immunity, is accomplished through somatic hypermutation of B-cell receptors followed by expansion of rare mutants with higher affinity for the immunising antigen. This process occurs over a period of weeks in unique micro-anatomic sites known as germinal centres. Two-photon microscopy has recently made it possible to track individual cells moving within germinal centres in living animals. Here we apply statistical approaches to test the hypothesis that B-cell motion is random. Our results show that activated B cells move in a directed manner that sharply contrasts with the behaviour of na?ve B cells." @default.
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- W2053441330 date "2011-01-01" @default.
- W2053441330 modified "2023-10-16" @default.
- W2053441330 title "Activated germinal centre B cells undergo directed migration" @default.
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- W2053441330 doi "https://doi.org/10.1504/ijdmb.2011.040387" @default.
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