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- W2053441492 endingPage "1884" @default.
- W2053441492 startingPage "1875" @default.
- W2053441492 abstract "Immunomodulatory drugs (IMiDs) and bortezomib have been recently used in the management of patients with both newly diagnosed and relapsed/refractory multiple myeloma. Except of their direct anti-myeloma effect, these agents also alter the interactions between myeloma cells and marrow microenvironment. Several recent studies have investigated their potential effect on myeloma bone disease. Preclinical studies have demonstrated that IMiDs reduce osteoclast formation and function in vitro. Clinical studies have confirmed that thalidomide reduces markers of bone resorption, while lenalidomide induces osteoclast arrest in myeloma patients. However, IMiDs seem to have no effect on osteoblast exhaustion present in myeloma. The proteasome inhibitor bortezomib restores abnormal bone remodeling through the inhibition of osteoclast function and the increase in osteoblast differentiation and activity in vitro. In myeloma patients, bortezomib reduces biochemical markers of bone resorption and normalizes the RANKL/osteoprotegerin ratio, while at the same time increases bone formation markers reducing levels of dickkopf-1 protein. Whether these effects are direct and not only a consequence of the agents' antimyeloma activity is not totally clear. This review summarizes all available data for these attractive agents that combine potent anti-myeloma activity with beneficial effects on bone and may alter the way of management of myeloma-related bone disease." @default.
- W2053441492 created "2016-06-24" @default.
- W2053441492 creator A5033573338 @default.
- W2053441492 creator A5041407463 @default.
- W2053441492 creator A5047187056 @default.
- W2053441492 date "2007-07-05" @default.
- W2053441492 modified "2023-10-12" @default.
- W2053441492 title "The effect of novel anti-myeloma agents on bone metabolism of patients with multiple myeloma" @default.
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