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- W2053443014 endingPage "448" @default.
- W2053443014 startingPage "429" @default.
- W2053443014 abstract "Complement fragment (C)5a is a 74 residue pro-inflammatory polypeptide produced during activation of the complement cascade of serum proteins in response to foreign surfaces such as microorganisms and tissue damaged by physical or chemical injury. C5a binds to at least two seven-transmembrane domain receptors, C5aR (C5R1, CD88) and C5L2 (gpr77), expressed ubiquitously on a wide variety of cells but particularly on the surface of immune cells like macrophages, neutrophils and T cells. C5aR is a classical G protein-coupled receptor that signals through G alpha i and G alpha 16, whereas C5L2 does not appear to couple to G proteins and has no known signalling activity. Although C5a was first described as an anaphylatoxin and later as a leukocyte chemoattractant, the widespread expression of C5aR suggested more general functionality. Our understanding of the physiology of C5a has improved significantly in recent years through exploitation of receptor knockout and knocking mice, C5 and C5a antibodies, soluble recombinant C5a and C5a analogues and newly developed receptor antagonists. C5a is now also implicated in non-immunological functions associated with developmental biology, CNS development and neurodegeneration, tissue regeneration, and haematopoiesis. Combined receptor mutagenesis, molecular modelling, structure-activity relationship studies and species dependence for ligand potency on C5aR have been helpful for identifying ligand binding sites on the receptor and for defining mechanisms of receptor activation and inactivation. This review will highlight major developments in C5a receptor research that support C5aR as an important therapeutic target. The intriguing possibilities raised by the existence of a non-signalling C5a receptor are also discussed." @default.
- W2053443014 created "2016-06-24" @default.
- W2053443014 creator A5003946834 @default.
- W2053443014 creator A5036981086 @default.
- W2053443014 creator A5048725428 @default.
- W2053443014 creator A5053439487 @default.
- W2053443014 date "2007-10-01" @default.
- W2053443014 modified "2023-10-14" @default.
- W2053443014 title "Function, structure and therapeutic potential of complement C5a receptors" @default.
- W2053443014 cites W135904687 @default.
- W2053443014 cites W1484805946 @default.
- W2053443014 cites W1485186526 @default.
- W2053443014 cites W1496640072 @default.
- W2053443014 cites W1498977263 @default.
- W2053443014 cites W1501153861 @default.
- W2053443014 cites W1506918918 @default.
- W2053443014 cites W1510455854 @default.
- W2053443014 cites W1519358455 @default.
- W2053443014 cites W1522434247 @default.
- W2053443014 cites W1525207872 @default.
- W2053443014 cites W1529949344 @default.
- W2053443014 cites W1541068518 @default.
- W2053443014 cites W1546290898 @default.
- W2053443014 cites W1547803511 @default.
- W2053443014 cites W1549204232 @default.
- W2053443014 cites W1553869327 @default.
- W2053443014 cites W1555752929 @default.
- W2053443014 cites W1562405836 @default.
- W2053443014 cites W1563349777 @default.
- W2053443014 cites W1569422489 @default.
- W2053443014 cites W1570213407 @default.
- W2053443014 cites W1580525952 @default.
- W2053443014 cites W1582349222 @default.
- W2053443014 cites W1584856024 @default.
- W2053443014 cites W1586560131 @default.
- W2053443014 cites W1592028829 @default.
- W2053443014 cites W1597762674 @default.
- W2053443014 cites W1626627453 @default.
- W2053443014 cites W1634549591 @default.
- W2053443014 cites W1751327912 @default.
- W2053443014 cites W1765347758 @default.
- W2053443014 cites W1776603764 @default.
- W2053443014 cites W1800839404 @default.
- W2053443014 cites W1839443743 @default.
- W2053443014 cites W1847565797 @default.
- W2053443014 cites W1852412583 @default.
- W2053443014 cites W1863355121 @default.
- W2053443014 cites W1864331618 @default.
- W2053443014 cites W1867704897 @default.
- W2053443014 cites W1882029866 @default.
- W2053443014 cites W1895961787 @default.
- W2053443014 cites W1904288160 @default.
- W2053443014 cites W1919495767 @default.
- W2053443014 cites W1934648117 @default.
- W2053443014 cites W1965480151 @default.
- W2053443014 cites W1966071218 @default.
- W2053443014 cites W1966460849 @default.
- W2053443014 cites W1967024742 @default.
- W2053443014 cites W1967562709 @default.
- W2053443014 cites W1967563793 @default.
- W2053443014 cites W1968544303 @default.
- W2053443014 cites W1968931100 @default.
- W2053443014 cites W1969797382 @default.
- W2053443014 cites W1970816982 @default.
- W2053443014 cites W1972084384 @default.
- W2053443014 cites W1972712561 @default.
- W2053443014 cites W1973220865 @default.
- W2053443014 cites W1974710770 @default.
- W2053443014 cites W1975140284 @default.
- W2053443014 cites W1975593747 @default.
- W2053443014 cites W1975807362 @default.
- W2053443014 cites W1976673134 @default.
- W2053443014 cites W1978496711 @default.
- W2053443014 cites W1979613397 @default.
- W2053443014 cites W1980941036 @default.
- W2053443014 cites W1981051332 @default.
- W2053443014 cites W1981821724 @default.
- W2053443014 cites W1983148583 @default.
- W2053443014 cites W1986074519 @default.
- W2053443014 cites W1987036950 @default.
- W2053443014 cites W1987577695 @default.
- W2053443014 cites W1988077852 @default.
- W2053443014 cites W1988384383 @default.
- W2053443014 cites W1989707466 @default.
- W2053443014 cites W1990231924 @default.
- W2053443014 cites W1990843685 @default.
- W2053443014 cites W1991378126 @default.
- W2053443014 cites W1992887367 @default.
- W2053443014 cites W1993075796 @default.
- W2053443014 cites W1993346410 @default.
- W2053443014 cites W1995921067 @default.
- W2053443014 cites W1996077240 @default.
- W2053443014 cites W1996259120 @default.
- W2053443014 cites W1998304266 @default.
- W2053443014 cites W1998827078 @default.
- W2053443014 cites W2000748318 @default.
- W2053443014 cites W2001647007 @default.
- W2053443014 cites W2002049130 @default.