FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053449086> ?p ?o ?g. }

• W2053449086 endingPage "4724" @default.
• W2053449086 startingPage "4714" @default.
• W2053449086 abstract "The global increase in measles vaccination has resulted in a significant reduction of measles mortality. The standard route of administration for the live-attenuated measles virus (MV) vaccine is subcutaneous injection, although alternative needle-free routes, including aerosol delivery, are under investigation. In vitro, attenuated MV has a much wider tropism than clinical isolates, as it can use both CD46 and CD150 as cellular receptors. To compare the in vivo tropism of attenuated and pathogenic MV, we infected cynomolgus macaques with pathogenic or attenuated recombinant MV expressing enhanced green fluorescent protein (GFP) (strains IC323 and Edmonston, respectively) via the intratracheal or aerosol route. Surprisingly, viral loads and cellular tropism in the lungs were similar for the two viruses regardless of the route of administration, and CD11c-positive cells were identified as the major target population. However, only the pathogenic MV caused significant viremia, which resulted in massive virus replication in B and T lymphocytes in lymphoid tissues and viral dissemination to the skin and the submucosa of respiratory epithelia. Attenuated MV was rarely detected in lymphoid tissues, and when it was, only in isolated infected cells. Following aerosol inhalation, attenuated MV was detected at early time points in the upper respiratory tract, suggesting local virus replication. This contrasts with pathogenic MV, which invaded the upper respiratory tract only after the onset of viremia. This study shows that despite in vitro differences, attenuated and pathogenic MV show highly similar in vivo tropism in the lungs. However, systemic spread of attenuated MV is restricted." @default.
• W2053449086 created "2016-06-24" @default.
• W2053449086 creator A5009236016 @default.
• W2053449086 creator A5012442242 @default.
• W2053449086 creator A5012707353 @default.
• W2053449086 creator A5014031296 @default.
• W2053449086 creator A5018562729 @default.
• W2053449086 creator A5031207622 @default.
• W2053449086 creator A5037052996 @default.
• W2053449086 creator A5047359982 @default.
• W2053449086 creator A5048652049 @default.
• W2053449086 creator A5074409519 @default.
• W2053449086 creator A5077144355 @default.
• W2053449086 date "2010-05-01" @default.
• W2053449086 modified "2023-10-18" @default.
• W2053449086 title "<i>In Vivo</i>Tropism of Attenuated and Pathogenic Measles Virus Expressing Green Fluorescent Protein in Macaques" @default.
• W2053449086 cites W1532024563 @default.
• W2053449086 cites W1533044537 @default.
• W2053449086 cites W1591890160 @default.
• W2053449086 cites W1592518891 @default.
• W2053449086 cites W1612424469 @default.
• W2053449086 cites W1845094941 @default.
• W2053449086 cites W1965686355 @default.
• W2053449086 cites W1967293609 @default.
• W2053449086 cites W1978452294 @default.
• W2053449086 cites W1985321438 @default.
• W2053449086 cites W2004020904 @default.
• W2053449086 cites W2022889753 @default.
• W2053449086 cites W2027334611 @default.
• W2053449086 cites W2032954528 @default.
• W2053449086 cites W2034996626 @default.
• W2053449086 cites W2036530886 @default.
• W2053449086 cites W2042288895 @default.
• W2053449086 cites W2054184136 @default.
• W2053449086 cites W2054959451 @default.
• W2053449086 cites W2061407907 @default.
• W2053449086 cites W2063539859 @default.
• W2053449086 cites W2074850109 @default.
• W2053449086 cites W2080740527 @default.
• W2053449086 cites W2081869933 @default.
• W2053449086 cites W2095900237 @default.
• W2053449086 cites W2096718612 @default.
• W2053449086 cites W2099336219 @default.
• W2053449086 cites W2100255826 @default.
• W2053449086 cites W2102769295 @default.
• W2053449086 cites W2103256609 @default.
• W2053449086 cites W2116805677 @default.
• W2053449086 cites W2124010557 @default.
• W2053449086 cites W2131019814 @default.
• W2053449086 cites W2139713123 @default.
• W2053449086 cites W2145320240 @default.
• W2053449086 cites W2150380586 @default.
• W2053449086 cites W2163969470 @default.
• W2053449086 cites W2169924388 @default.
• W2053449086 cites W2341268770 @default.
• W2053449086 cites W76787895 @default.
• W2053449086 doi "https://doi.org/10.1128/jvi.02633-09" @default.
• W2053449086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2863733" @default.
• W2053449086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20181691" @default.
• W2053449086 hasPublicationYear "2010" @default.
• W2053449086 type Work @default.
• W2053449086 sameAs 2053449086 @default.
• W2053449086 citedByCount "96" @default.
• W2053449086 countsByYear W20534490862012 @default.
• W2053449086 countsByYear W20534490862013 @default.
• W2053449086 countsByYear W20534490862014 @default.
• W2053449086 countsByYear W20534490862015 @default.
• W2053449086 countsByYear W20534490862016 @default.
• W2053449086 countsByYear W20534490862017 @default.
• W2053449086 countsByYear W20534490862018 @default.
• W2053449086 countsByYear W20534490862019 @default.
• W2053449086 countsByYear W20534490862020 @default.
• W2053449086 countsByYear W20534490862021 @default.
• W2053449086 countsByYear W20534490862022 @default.
• W2053449086 countsByYear W20534490862023 @default.
• W2053449086 crossrefType "journal-article" @default.
• W2053449086 hasAuthorship W2053449086A5009236016 @default.
• W2053449086 hasAuthorship W2053449086A5012442242 @default.
• W2053449086 hasAuthorship W2053449086A5012707353 @default.
• W2053449086 hasAuthorship W2053449086A5014031296 @default.
• W2053449086 hasAuthorship W2053449086A5018562729 @default.
• W2053449086 hasAuthorship W2053449086A5031207622 @default.
• W2053449086 hasAuthorship W2053449086A5037052996 @default.
• W2053449086 hasAuthorship W2053449086A5047359982 @default.
• W2053449086 hasAuthorship W2053449086A5048652049 @default.
• W2053449086 hasAuthorship W2053449086A5074409519 @default.
• W2053449086 hasAuthorship W2053449086A5077144355 @default.
• W2053449086 hasBestOaLocation W20534490862 @default.
• W2053449086 hasConcept C104317684 @default.
• W2053449086 hasConcept C105702510 @default.
• W2053449086 hasConcept C159047783 @default.
• W2053449086 hasConcept C203014093 @default.
• W2053449086 hasConcept C22070199 @default.
• W2053449086 hasConcept C2522874641 @default.
• W2053449086 hasConcept C2776185481 @default.
• W2053449086 hasConcept C2776438120 @default.
• W2053449086 hasConcept C2778199166 @default.
• W2053449086 hasConcept C2779644171 @default.

• next