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• W2053452562 abstract "Contagious bovine pleuropneumonia (CBPP) remains a major cattle disease in Africa with serious socio-economic consequences. Its eradication requires the development of improved vaccines. Knowledge on this disease and its causing agent, Mycoplasma mycoides subsp. mycoides biotype Small Colony (MmmSC), has been progressing significantly in the last years, opening new areas for vaccine design. Advances were achieved in the understanding of the protective immune responses to MmmSC infection and immunopathological mechanisms allowing the pathogen to escape the host immune response. Based on sequencing and genomic studies, some virulence factors and metabolic pathways were unraveled leading to the identification of potential MmmSC vaccine candidates. Based on these findings, this review presents a scientific strategy to design multi-component sub-unit vaccines for mucosal delivery as the most promising approach for efficient long-term protective vaccines to prevent CBPP. La péripneumonie contagieuse bovine reste une maladie majeure des bovins en Afrique avec de sérieuses conséquences socio-économiques. Son éradication nécessite le développement de vaccins améliorés. Ces dernières années, les connaissances de cette maladie comme de l’agent pathogène responsable, Mycoplasma mycoides subsp. mycoides biotype Small Colony (MmmSC), ont largement évolué, ouvrant la voie à de nouvelles approches vaccinales. Ces avancées ont été obtenues dans la compréhension des réponses immunitaires protectrices face à MmmSC ainsi que des mécanismes immunopathologiques permettant à MmmSC d’échapper à la réponse de l’hôte. De plus, grâce au séquençage et à des études génomiques, certains facteurs de virulence et cycles métaboliques de MmmSC ont été caractérisés permettant l’identification de candidats vaccinaux potentiels. A partir de ces données, cette revue présente une stratégie scientifique pour le développement de vaccins sous-unitaires multi-composants à délivrance mucosale, comme étant l’approche la plus prometteuse pour des vaccins protecteurs à long terme contre la PPCB." @default.
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• W2053452562 date "2008-03-01" @default.
• W2053452562 modified "2023-09-27" @default.
• W2053452562 title "Contagious bovine pleuropneumonia: A rationale for the development of a mucosal sub-unit vaccine" @default.
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• W2053452562 doi "https://doi.org/10.1016/j.cimid.2007.07.009" @default.
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