FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053453668> ?p ?o ?g. }

• W2053453668 endingPage "548" @default.
• W2053453668 startingPage "541" @default.
• W2053453668 abstract "Background Decreased hippocampal volume is described in posttraumatic stress disorder (PTSD) and depression. However, it is not known whether it is a risk factor for the development of PTSD or a consequence of PTSD. We sought to determine the effects of PTSD and depressive symptoms on hippocampal volume. Methods Clinical and magnetic resonance imaging data were collected in a cross sectional study of 244 Gulf War veterans. Measures included lifetime and current Clinician Administered PTSD Scale, Hamilton Depression Scale, Life Stressor Checklist, and Lifetime Drinking History. Magnetic resonance imaging data were acquired with a 1.5-T scanner and analyzed with automated and semiautomated image processing techniques. Results Eighty-two veterans had lifetime PTSD, 44 had current PTSD, and 38 had current depression. In the linear regression analysis, current PTSD symptoms (standardized coefficient β = −.25, p = .03) but neither lifetime PTSD symptoms nor current depression were associated with smaller hippocampal volume. Gender, age, history of early life trauma, education, lifetime and current alcohol use, current marijuana use, and treatment with antidepressants did not have independent effects. Participants with chronic PTSD had, on average, a smaller hippocampus compared with those with remitted PTSD. Conclusions The finding that current but not lifetime PTSD symptom severity explains hippocampal size raises two possibilities: either a small hippocampus is a risk factor for lack of recovery from PTSD (trait) or PTSD effects on hippocampal volume are reversible once PTSD symptoms remit and the patient recovers (state). Decreased hippocampal volume is described in posttraumatic stress disorder (PTSD) and depression. However, it is not known whether it is a risk factor for the development of PTSD or a consequence of PTSD. We sought to determine the effects of PTSD and depressive symptoms on hippocampal volume. Clinical and magnetic resonance imaging data were collected in a cross sectional study of 244 Gulf War veterans. Measures included lifetime and current Clinician Administered PTSD Scale, Hamilton Depression Scale, Life Stressor Checklist, and Lifetime Drinking History. Magnetic resonance imaging data were acquired with a 1.5-T scanner and analyzed with automated and semiautomated image processing techniques. Eighty-two veterans had lifetime PTSD, 44 had current PTSD, and 38 had current depression. In the linear regression analysis, current PTSD symptoms (standardized coefficient β = −.25, p = .03) but neither lifetime PTSD symptoms nor current depression were associated with smaller hippocampal volume. Gender, age, history of early life trauma, education, lifetime and current alcohol use, current marijuana use, and treatment with antidepressants did not have independent effects. Participants with chronic PTSD had, on average, a smaller hippocampus compared with those with remitted PTSD. The finding that current but not lifetime PTSD symptom severity explains hippocampal size raises two possibilities: either a small hippocampus is a risk factor for lack of recovery from PTSD (trait) or PTSD effects on hippocampal volume are reversible once PTSD symptoms remit and the patient recovers (state)." @default.
• W2053453668 created "2016-06-24" @default.
• W2053453668 creator A5016589490 @default.
• W2053453668 creator A5019714473 @default.
• W2053453668 creator A5022972137 @default.
• W2053453668 creator A5043086041 @default.
• W2053453668 creator A5044485966 @default.
• W2053453668 creator A5053096250 @default.
• W2053453668 creator A5061688691 @default.
• W2053453668 creator A5077461136 @default.
• W2053453668 creator A5083813224 @default.
• W2053453668 date "2011-03-01" @default.
• W2053453668 modified "2023-10-18" @default.
• W2053453668 title "Hippocampal Volume Differences in Gulf War Veterans with Current Versus Lifetime Posttraumatic Stress Disorder Symptoms" @default.
• W2053453668 cites W1550462067 @default.
• W2053453668 cites W1804267428 @default.
• W2053453668 cites W1914011667 @default.
• W2053453668 cites W1972448819 @default.
• W2053453668 cites W1972936594 @default.
• W2053453668 cites W1976711431 @default.
• W2053453668 cites W1977550486 @default.
• W2053453668 cites W1980508260 @default.
• W2053453668 cites W1987604172 @default.
• W2053453668 cites W1990168531 @default.
• W2053453668 cites W1992377856 @default.
• W2053453668 cites W1994547251 @default.
• W2053453668 cites W2004643104 @default.
• W2053453668 cites W2005653958 @default.
• W2053453668 cites W2010523062 @default.
• W2053453668 cites W2017638772 @default.
• W2053453668 cites W2018031501 @default.
• W2053453668 cites W2020897240 @default.
• W2053453668 cites W2023060626 @default.
• W2053453668 cites W2030772288 @default.
• W2053453668 cites W2042355083 @default.
• W2053453668 cites W2044540853 @default.
• W2053453668 cites W2045881156 @default.
• W2053453668 cites W2049275104 @default.
• W2053453668 cites W2053508049 @default.
• W2053453668 cites W2063377862 @default.
• W2053453668 cites W2064212981 @default.
• W2053453668 cites W2074280539 @default.
• W2053453668 cites W2075370186 @default.
• W2053453668 cites W2083433650 @default.
• W2053453668 cites W2085417640 @default.
• W2053453668 cites W2087953568 @default.
• W2053453668 cites W2103752895 @default.
• W2053453668 cites W2104386846 @default.
• W2053453668 cites W2105086774 @default.
• W2053453668 cites W2108641718 @default.
• W2053453668 cites W2112518510 @default.
• W2053453668 cites W2114214919 @default.
• W2053453668 cites W2114613490 @default.
• W2053453668 cites W2115762181 @default.
• W2053453668 cites W2118439943 @default.
• W2053453668 cites W2120348003 @default.
• W2053453668 cites W2121358117 @default.
• W2053453668 cites W2123305958 @default.
• W2053453668 cites W2129742671 @default.
• W2053453668 cites W2129902706 @default.
• W2053453668 cites W2133565799 @default.
• W2053453668 cites W2141757584 @default.
• W2053453668 cites W2144186309 @default.
• W2053453668 cites W2145267709 @default.
• W2053453668 cites W2145944042 @default.
• W2053453668 cites W2147909291 @default.
• W2053453668 cites W2148997797 @default.
• W2053453668 cites W2151602227 @default.
• W2053453668 cites W2151721316 @default.
• W2053453668 cites W2151775239 @default.
• W2053453668 cites W2157502851 @default.
• W2053453668 cites W2158352058 @default.
• W2053453668 cites W2161851141 @default.
• W2053453668 cites W2167179332 @default.
• W2053453668 cites W2170074336 @default.
• W2053453668 cites W2414031008 @default.
• W2053453668 cites W4247268564 @default.
• W2053453668 cites W4249129794 @default.
• W2053453668 doi "https://doi.org/10.1016/j.biopsych.2010.09.044" @default.
• W2053453668 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3259803" @default.
• W2053453668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21094937" @default.
• W2053453668 hasPublicationYear "2011" @default.
• W2053453668 type Work @default.
• W2053453668 sameAs 2053453668 @default.
• W2053453668 citedByCount "116" @default.
• W2053453668 countsByYear W20534536682012 @default.
• W2053453668 countsByYear W20534536682013 @default.
• W2053453668 countsByYear W20534536682014 @default.
• W2053453668 countsByYear W20534536682015 @default.
• W2053453668 countsByYear W20534536682016 @default.
• W2053453668 countsByYear W20534536682017 @default.
• W2053453668 countsByYear W20534536682018 @default.
• W2053453668 countsByYear W20534536682019 @default.
• W2053453668 countsByYear W20534536682020 @default.
• W2053453668 countsByYear W20534536682021 @default.
• W2053453668 countsByYear W20534536682022 @default.
• W2053453668 countsByYear W20534536682023 @default.
• W2053453668 crossrefType "journal-article" @default.

• next