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- W2053457187 endingPage "1079" @default.
- W2053457187 startingPage "1066" @default.
- W2053457187 abstract "Genome-wide association studies (GWAS) use high-throughput genotyping technologies to genotype thousands of single-nucleotide polymorphisms (SNPs) and relate them to the development of clinical and quantitative traits. Their use has been highly successful in the field of ophthalmology, and since the advent of GWAS in 2005, many genes not previously suspected of having a role in disease have been identified and the findings replicated. We conducted an extensive literature review and describe the concept, design, advantages, and limitations of GWAS and provide a detailed description of the applications and discoveries of GWAS in the field of eye disease to date. There have been many novel findings revealing previously unknown biological insights in a diverse range of common ocular conditions. GWAS have been a highly successful modality for investigating the pathogenesis of a wide variety of ophthalmic conditions. The insights gained into the pathogenesis of disease provide not only a better understanding of underlying disease mechanism but also offer a rationale for targeted treatment and preventative strategies. Expansive international collaboration and standardised phenotyping will permit the continued success of this investigative technique." @default.
- W2053457187 created "2016-06-24" @default.
- W2053457187 creator A5010674928 @default.
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- W2053457187 creator A5070568170 @default.
- W2053457187 creator A5070714767 @default.
- W2053457187 creator A5089705928 @default.
- W2053457187 date "2014-06-27" @default.
- W2053457187 modified "2023-10-17" @default.
- W2053457187 title "Genome-wide association studies: applications and insights gained in Ophthalmology" @default.
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