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• W2053457966 abstract "Alkylating agents are ubiquitous in the human environment and are continuously synthesized in vivo. Although many classes exist, interest has been focused on the N-nitroso compounds, since many are mutagens for bacteria, phage, and cells, and carcinogens for mammals. In contrast to aromatic amines and polyaromatic hydrocarbons which can react at carbons, simple alkylating agents react with nitrogens and oxygens: 13 sites are possible, including the internucleotide phosphodiester. However, only the N-nitroso compounds react extensively with oxygens. In vivo, most possible derivatives have been found after administration of methyl and ethyl nitroso compounds. The ethylating agents are more reactive toward oxygens than are the methylating agents and are more carcinogenic in terms of total alkylation. This is true regardless of whether or not the compounds require metabolic activation. It has been hypothesized that the level and persistence of specific derivatives in a" @default.
• W2053457966 created "2016-06-24" @default.
• W2053457966 creator A5052833149 @default.
• W2053457966 date "1985-10-01" @default.
• W2053457966 modified "2023-09-29" @default.
• W2053457966 title "In vivo formation and persistence of modified nucleosides resulting from alkylating agents." @default.
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• W2053457966 doi "https://doi.org/10.1289/ehp.856241" @default.
• W2053457966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1568687" @default.
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