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• W2053466657 abstract "The HIV-1 Vpr protein induces apoptosis of cells, the mechanism of which is unknown. To clarify how this function may be related to other Vpr functions, we simultaneously assessed the effects of multiple point mutations upon various Vpr properties. Our data suggest that induction of arrest by Vpr may be unnecessary for induction of apoptosis. This is exemplified by a C-terminal mutant, R80A, that does not arrest cells, yet induces low but significant levels of apoptosis. We also show that mutation of Vpr at both of its nuclear localization sequences (within its alpha-helices and the overlapping leucine zipper-like domain) does not affect induction of either apoptosis or cell cycle arrest. This indicates that neither sequence is essential for these two functions of Vpr. It further suggests that multimerization of Vpr, which maps to residues 60 and 67 within the leucine-rich region, is unnecessary for initiation of apoptosis and arrest. We previously found that the Vpr-binding protein, hHR23A, can partially alleviate induction of arrest. We now show that overexpression of hHR23A itself causes apoptosis of cells. Mutation of its C-terminal UBA( 2 ) domain that is responsible for binding Vpr disrupts the apoptotic effect. This suggests that Vpr may induce apoptosis through a pathway involving hHR23A." @default.
• W2053466657 created "2016-06-24" @default.
• W2053466657 creator A5037329047 @default.
• W2053466657 creator A5048646352 @default.
• W2053466657 date "2001-07-01" @default.
• W2053466657 modified "2023-10-12" @default.
• W2053466657 title "Analysis of Apoptosis Induced by HIV-1 Vpr and Examination of the Possible Role of the hHR23A Protein" @default.
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• W2053466657 cites W1511997451 @default.
• W2053466657 cites W1538467835 @default.
• W2053466657 cites W1540165068 @default.
• W2053466657 cites W1557691749 @default.
• W2053466657 cites W1584557115 @default.
• W2053466657 cites W1585763437 @default.
• W2053466657 cites W1588896166 @default.
• W2053466657 cites W1625926039 @default.
• W2053466657 cites W1714042500 @default.
• W2053466657 cites W1807747199 @default.
• W2053466657 cites W1906824465 @default.
• W2053466657 cites W1916442090 @default.
• W2053466657 cites W1925504181 @default.
• W2053466657 cites W1954751611 @default.
• W2053466657 cites W1963991581 @default.
• W2053466657 cites W1972784739 @default.
• W2053466657 cites W1973208298 @default.
• W2053466657 cites W1973782438 @default.
• W2053466657 cites W1979606611 @default.
• W2053466657 cites W1981498914 @default.
• W2053466657 cites W1981938779 @default.
• W2053466657 cites W1983747887 @default.
• W2053466657 cites W1985903968 @default.
• W2053466657 cites W1991494214 @default.
• W2053466657 cites W2001243226 @default.
• W2053466657 cites W2007150582 @default.
• W2053466657 cites W2010840723 @default.
• W2053466657 cites W2011104403 @default.
• W2053466657 cites W2017447440 @default.
• W2053466657 cites W2025450862 @default.
• W2053466657 cites W2027214164 @default.
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• W2053466657 cites W2048656467 @default.
• W2053466657 cites W2049958866 @default.
• W2053466657 cites W2050446750 @default.
• W2053466657 cites W2050662558 @default.
• W2053466657 cites W2052229975 @default.
• W2053466657 cites W2053294769 @default.
• W2053466657 cites W2053332066 @default.
• W2053466657 cites W2069574267 @default.
• W2053466657 cites W2072901265 @default.
• W2053466657 cites W2080625914 @default.
• W2053466657 cites W2084353070 @default.
• W2053466657 cites W2087480936 @default.
• W2053466657 cites W2094023425 @default.
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• W2053466657 cites W2132333091 @default.
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• W2053466657 doi "https://doi.org/10.1006/excr.2001.5247" @default.
• W2053466657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11426943" @default.
• W2053466657 hasPublicationYear "2001" @default.
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• W2053466657 hasAuthorship W2053466657A5037329047 @default.
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