FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053467897> ?p ?o ?g. }

• W2053467897 abstract "Humans are colonized from birth by bacteria, which form a complex and dynamic consortium of microorganisms known as microbiota. Overall, this complex microbial community outnumbers the somatic and germ cells of the host and collectively contains significantly higher genetic variability than that of the host genome (Backhed et al. 2005). Health-promoting indigenous bacteria, known as probiotic bacteria, represent a significant proportion of the human gut microbiota, whose composition is modulated by several factors including diet (Muegge et al. 2011). Probiotic bacteria are often introduced as live dietary supplements, but they are also present as live microflora in fermented foodstuffs for human consumption. The molecular mechanisms by which probiotics beneficially affect human health include strengthening of the intestinal barrier, modulation of the immune response and antagonism of pathogens through production of antimicrobial compounds or competition for mucosal binding sites (Marco et al. 2006). A significant proportion of the commercialized probiotic bacterial species was originally selected on the basis of their technological stability (e.g., resistance and viability during food processing and storage) or by a variety of easily measurable phenotypes, such as the ability to tolerate bile salts or to survive passage through the gastro-intestinal tract. These features do not necessarily associate with capabilities to provide human health benefits. Regulatory requirements concerning probiotic products are currently undergoing a profound transformation that will require elucidation of the mechanisms by which probiotic microorganisms beneficially influence human health. In order to achieve such fine characterization, the so-called “omics” approaches involving genomics and functional analysis represent an essential tool. In particular, probiogenomics, a recently proposed genomic discipline (Ventura et al. 2009), provides insights into the diversity and the evolution of probiotic microorganisms, thus allowing to clarify the molecular basis of their health-promoting activities. Probiogenomics also includes functional genomics, as well as investigation of microbe–microbe and host-microbe interactions that represent crucial aspects to expand our understanding of the roles of probiotics.The study of probiotic bacteria must necessarily take into account recent advances on the microbial ecology of the human gut. Elucidation of the bacterial biodiversity encompassing such a complex ecosystem is essential to highlight the presence or absence of specific groups of microorganisms (microbial biomarkers) and their association with health/disease conditions. In-depth knowledge of the composition and functionality of the human gut microbiota can also provide molecular criteria to predict individual susceptibility to specific probiotic supplements and could be utilized as a priori criteria for successful probiotic therapy. For all these reasons, we believe that a special issue of Genes & Nutrition devoted to probiotic bacteria and human gut microbiota is extremely appropriate.Two reviews within this special issue deal with the genomics of lactobacilli (Alterman et al.) and bifidobacteria (Pokusaeva et al.), which are considered the golden stars among probiotic bacteria. Probiotics are subject to several stressful conditions during industrial processing as well as in nature, where a fast stress-response is essential for survival (Ventura et al. 2006). Genetic characterization of the molecular players that enable probiotic bacteria to cope with such stressful stimuli are discussed by Ruiz et al. Microbial diversity within the human intestinal community is reported by Gerritsen et al., with special focus on the contribution of the gut microbiota to the health/disease balance. The impact of bacteriophages in modulating gut microbiota, as well as on bacterial survival and thus on the efficacy of probiotic treatments is described by Ventura et al. Prebiotic approaches represent new avenues for manipulating gut microbial composition and host responses to achieve health benefits. Conterno et al. explore the possible relationships between prebiotics and modulation of bifidobacterial and lactobacilli populations in the human gut, as a potential tool for obesity prevention and treatment. The effects of probiotics on human health are further discussed by Taverniti and Guglielmetti, who review the current knowledge on interactions of gut bacteria with the mammalian immune system. Safety is a crucial pre-requisite that probiotic bacteria must possess, and safety validation of probiotics includes exclusion of pathogenic potential. A key food safety issue reviewed by Devirgiliis et al. is the potential presence of horizontally transferable antibiotic resistance genes in probiotic strains naturally present in fermented foods, which can interact with the gut microbiota through the food chain.We wish to thank all authors who provided their manuscripts for this special issue, as well as all reviewers involved in processing the submitted articles. Overall, such a collective effort has provided a clear picture of the rapid progress occurring in the field of biology of probiotic bacteria, with special focus on the health benefits resulting from their interactions with the human host." @default.
• W2053467897 created "2016-06-24" @default.
• W2053467897 creator A5065241356 @default.
• W2053467897 creator A5066748824 @default.
• W2053467897 date "2011-07-21" @default.
• W2053467897 modified "2023-10-11" @default.
• W2053467897 title "Introduction to the special issue “Probiotic bacteria and human gut microbiota”" @default.
• W2053467897 cites W1980626819 @default.
• W2053467897 cites W1980914602 @default.
• W2053467897 cites W2008054523 @default.
• W2053467897 cites W2033637067 @default.
• W2053467897 cites W2112874908 @default.
• W2053467897 doi "https://doi.org/10.1007/s12263-011-0241-y" @default.
• W2053467897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3145059" @default.
• W2053467897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21779936" @default.
• W2053467897 hasPublicationYear "2011" @default.
• W2053467897 type Work @default.
• W2053467897 sameAs 2053467897 @default.
• W2053467897 citedByCount "12" @default.
• W2053467897 countsByYear W20534678972012 @default.
• W2053467897 countsByYear W20534678972014 @default.
• W2053467897 countsByYear W20534678972018 @default.
• W2053467897 countsByYear W20534678972019 @default.
• W2053467897 countsByYear W20534678972020 @default.
• W2053467897 countsByYear W20534678972022 @default.
• W2053467897 crossrefType "journal-article" @default.
• W2053467897 hasAuthorship W2053467897A5065241356 @default.
• W2053467897 hasAuthorship W2053467897A5066748824 @default.
• W2053467897 hasBestOaLocation W20534678971 @default.
• W2053467897 hasConcept C203014093 @default.
• W2053467897 hasConcept C2780255968 @default.
• W2053467897 hasConcept C2992479659 @default.
• W2053467897 hasConcept C523546767 @default.
• W2053467897 hasConcept C539455810 @default.
• W2053467897 hasConcept C54355233 @default.
• W2053467897 hasConcept C86803240 @default.
• W2053467897 hasConcept C89423630 @default.
• W2053467897 hasConceptScore W2053467897C203014093 @default.
• W2053467897 hasConceptScore W2053467897C2780255968 @default.
• W2053467897 hasConceptScore W2053467897C2992479659 @default.
• W2053467897 hasConceptScore W2053467897C523546767 @default.
• W2053467897 hasConceptScore W2053467897C539455810 @default.
• W2053467897 hasConceptScore W2053467897C54355233 @default.
• W2053467897 hasConceptScore W2053467897C86803240 @default.
• W2053467897 hasConceptScore W2053467897C89423630 @default.
• W2053467897 hasIssue "3" @default.
• W2053467897 hasLocation W20534678971 @default.
• W2053467897 hasLocation W20534678972 @default.
• W2053467897 hasLocation W20534678973 @default.
• W2053467897 hasLocation W20534678974 @default.
• W2053467897 hasOpenAccess W2053467897 @default.
• W2053467897 hasPrimaryLocation W20534678971 @default.
• W2053467897 hasRelatedWork W1976885917 @default.
• W2053467897 hasRelatedWork W2460075091 @default.
• W2053467897 hasRelatedWork W2605691951 @default.
• W2053467897 hasRelatedWork W2902853470 @default.
• W2053467897 hasRelatedWork W2912004885 @default.
• W2053467897 hasRelatedWork W3044552023 @default.
• W2053467897 hasRelatedWork W3088044871 @default.
• W2053467897 hasRelatedWork W3199590428 @default.
• W2053467897 hasRelatedWork W3208830999 @default.
• W2053467897 hasRelatedWork W3044703277 @default.
• W2053467897 hasVolume "6" @default.
• W2053467897 isParatext "false" @default.
• W2053467897 isRetracted "false" @default.
• W2053467897 magId "2053467897" @default.
• W2053467897 workType "article" @default.