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• W2053473025 abstract "MicroRNAs (miRNAs) have been demonstrated to play important roles in tumorigenesis of human cancer. Fewer studies have explored the roles of miR-100 on human colorectal cancer cell proliferation and invasion. In this study, we utilized real-time PCR to verify whether miR-100 was downregulated in human colorectal cancer tissues compared with matched adjacent normal tissues. Functional studies demonstrated that ectopic expression of miR-100 inhabits cell growth and invasion and induce apoptosis, whereas knockdown of miR-100 yielded the reverse phenotype. Mechanistic studies reveal that miR-100 repressed the activity of a reporter gene fused to the 3'-untranslated region (3'-UTR) of RAP1B, whereas miR-100 silencing upregulated the expression of the reporter gene. Furthermore, we also detected that RAP1B mRNA was inversely expressed with miR-100 in colorectal cancer tissues. These data indicate that the miR-100 plays a tumor suppressor role by regulating colorectal cancer cell growth and invasion phenotype, and could serve as a potential maker for colorectal cancer therapy." @default.
• W2053473025 created "2016-06-24" @default.
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• W2053473025 date "2014-03-11" @default.
• W2053473025 modified "2023-09-27" @default.
• W2053473025 title "MicroRNA-100 regulates SW620 colorectal cancer cell proliferation and invasion by targeting RAP1B" @default.
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• W2053473025 doi "https://doi.org/10.3892/or.2014.3075" @default.
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