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- W2053478748 abstract "We previously investigated the progression of amyloid-β deposition in brain of mice over-expressing amyloid-precursor protein (APP-Swe), a model of Alzheimer's disease (AD), in a longitudinal PET study with the novel amyloid-β tracer [18 F]florbetaben. Here we describe the double-transgenic mouse model APP23xPS45 (G384A), developing a faster amyloid progression. Furthermore signal loss due to partial volume effects is a well-known problem especially in microPET studies, therefore we aimed to investigate corrections for partial volume effects (PVC). Emission recordings were acquired using an Inveon microPET following administration of [18 F]florbetaben (8 MBq, i.v.) in G384A mice aged 5.5 and 16 months compared to longitudinally studied APP-Swe mice aged 13 to 20 months as well as age-matched wild-type (WT) mi ce. After spatial nor malization, cortex-to-cerebellum ratios (SUVR) were calculated using a volume-of-interest (VOI) approach. Subsequently a VOI-based PVC algorithm was applied on in vivo microPET data and compared to uncorrected quantitation. Cortical florbetaben binding increased significantly over time in G384A mice and exceeded the mean 20-month-level of APP-Swe mice at 16 months of age. Without PVC cortical SUVR increased over time in transgenic mice aged 16 months compared to baseline estimates (+6.0%; p<0.05) or age-matched WT mice (+5.7%; p<0.05). The PVC increased mean cortical SUV by 65.8%, while mean cerebellar SUV increased by 33.3%, therefore SUVR increased within groups longitudinally by 10.1% (p<0.01) compared to baseline and by 10.6% (p<0.01) compared to WT mice." @default.
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- W2053478748 date "2013-07-01" @default.
- W2053478748 modified "2023-09-27" @default.
- W2053478748 title "IC-P-040: PET imaging using [18F]florbetaben in Alzheimer's disease mouse models" @default.
- W2053478748 doi "https://doi.org/10.1016/j.jalz.2013.05.041" @default.
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