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- W2053483729 abstract "In this work, we evaluated the effects of administration of OVA on phenotype and function of intraepithelial lymphocytes (IELs) from small intestine of transgenic (TGN) DO11.10 and wild-type BALB/c mice. While the small intestines from BALB/c presented a well preserved structure, those from TGN showed an inflamed aspect. The ingestion of OVA induced a reduction in the number of IELs in small intestines of TGN, but it did not change the frequencies of CD8 + and CD4 + T-cell subsets. Administration of OVA via oral + ip increased the frequency of CD103 + cells in CD4 + T-cell subset in IELs of both BALB/c and TGN mice and elevated its expression in CD8 β + T-cell subset in IELs of TGN. The frequency of Foxp3 + cells increased in all subsets in IELs of BALB/c treated with OVA; in IELs of TGN, it increased only in CD25 + subset. IELs from BALB/c tolerant mice had lower expression of all cytokines studied, whereas those from TGN showed high expression of inflammatory cytokines, especially of IFN- γ , TGF- β , and TNF- α . Overall, our results suggest that the inability of TGN to become tolerant may be related to disorganization and altered proportions of inflammatory/regulatory T cells in its intestinal mucosa." @default.
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- W2053483729 date "2012-01-01" @default.
- W2053483729 modified "2023-10-16" @default.
- W2053483729 title "Phenotypical and Functional Analysis of Intraepithelial Lymphocytes from Small Intestine of Mice in Oral Tolerance" @default.
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- W2053483729 doi "https://doi.org/10.1155/2012/208054" @default.
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