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• W2053485292 abstract "The erbB2 gene, which encodes a transmembrane growth factor receptor, is overexpressed in approximately 30% of breast cancers. Overexpressing this gene makes breast cancers resistant to certain chemotherapeutic agents. In this article, we review what is known about ErbB2-mediated chemoresistance and the controversies surrounding it. We also examine the antiapoptotic function of erbB2 as one of the molecular mechanisms of ErbB2-mediated Taxol resistance and describe several emerging strategies for overcoming intrinsic ErbB2-mediated chemoresistance. Finally, we discuss future avenues for studies of chemosensitivity in ErbB2-overexpressing breast cancers that may lead to the development of effective biology-based treatment strategies." @default.
• W2053485292 created "2016-06-24" @default.
• W2053485292 creator A5076834432 @default.
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• W2053485292 date "2000-06-23" @default.
• W2053485292 modified "2023-10-17" @default.
• W2053485292 title "Role of erbB2 in breast cancer chemosensitivity" @default.
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• W2053485292 doi "https://doi.org/10.1002/1521-1878(200007)22:7<673::aid-bies10>3.0.co;2-a" @default.
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