Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053485332> ?p ?o ?g. }
- W2053485332 endingPage "326" @default.
- W2053485332 startingPage "316" @default.
- W2053485332 abstract "Bortezomib (BTZ) is the first clinically approved proteasome inhibitor for treating multiple human malignancies. However, the poor water-solubility and low stability of BTZ and the emergence of tumor resistance have severely restrained its therapeutic efficacy. Herein, we report the application of hollow mesoporous silica nanospheres (HMSNs) in encapsulating BTZ for drug delivery. In in vitro cell viability assay on human NSCLC H1299 cells, the half-maximum inhibiting concentration (IC50) of HMSNs–BTZ was 42% of that for free BTZ in 48 h treatments. In vivo tumor-suppression assay further indicated that HMSNs–BTZ (0.3 mg/kg) showed approximately 1.5 folds stronger anti-tumor activity than free BTZ. Furthermore, we report that more potent induction of cell cycle arrest and apoptotic cell death, along with promoted activation of Caspase 3 and autophagy might mechanistically underlie the improved anti-tumor efficacy of HMSNs–BTZ. Finally, the tumor-suppressing effect of HMSNs–BTZ was enhanced in the presence of wild-type p53 signaling, suggesting a potential enhancement in clinical efficacy with combined p53 gene therapy and BTZ-based chemotherapy. Therefore, the HMSNs-based nanoparticles are emerging as a promising platform to deliver therapeutic agents for beneficial clinical outcomes through lowering doses and frequency of drug administration and reducing potential side effects." @default.
- W2053485332 created "2016-06-24" @default.
- W2053485332 creator A5011492361 @default.
- W2053485332 creator A5039254367 @default.
- W2053485332 creator A5043093852 @default.
- W2053485332 creator A5044166963 @default.
- W2053485332 creator A5065145945 @default.
- W2053485332 creator A5071177970 @default.
- W2053485332 creator A5072979414 @default.
- W2053485332 creator A5085578187 @default.
- W2053485332 date "2014-01-01" @default.
- W2053485332 modified "2023-10-16" @default.
- W2053485332 title "The use of hollow mesoporous silica nanospheres to encapsulate bortezomib and improve efficacy for non-small cell lung cancer therapy" @default.
- W2053485332 cites W1583113866 @default.
- W2053485332 cites W1597327777 @default.
- W2053485332 cites W1969648097 @default.
- W2053485332 cites W1975088956 @default.
- W2053485332 cites W1979895323 @default.
- W2053485332 cites W1981390207 @default.
- W2053485332 cites W1981748118 @default.
- W2053485332 cites W1982650056 @default.
- W2053485332 cites W2003315550 @default.
- W2053485332 cites W2019527474 @default.
- W2053485332 cites W2021174335 @default.
- W2053485332 cites W2023338496 @default.
- W2053485332 cites W2023843074 @default.
- W2053485332 cites W2031403784 @default.
- W2053485332 cites W2034735099 @default.
- W2053485332 cites W2036340440 @default.
- W2053485332 cites W2054298919 @default.
- W2053485332 cites W2055776993 @default.
- W2053485332 cites W2057718146 @default.
- W2053485332 cites W2059318369 @default.
- W2053485332 cites W2068132005 @default.
- W2053485332 cites W2070703268 @default.
- W2053485332 cites W2072864417 @default.
- W2053485332 cites W2080619461 @default.
- W2053485332 cites W2082015682 @default.
- W2053485332 cites W2082511916 @default.
- W2053485332 cites W2083831464 @default.
- W2053485332 cites W2089513781 @default.
- W2053485332 cites W2090637305 @default.
- W2053485332 cites W2091731059 @default.
- W2053485332 cites W2099395323 @default.
- W2053485332 cites W2100826259 @default.
- W2053485332 cites W2102618395 @default.
- W2053485332 cites W2107997405 @default.
- W2053485332 cites W2108235071 @default.
- W2053485332 cites W2109488901 @default.
- W2053485332 cites W2123077018 @default.
- W2053485332 cites W2127061733 @default.
- W2053485332 cites W2127330780 @default.
- W2053485332 cites W2127919472 @default.
- W2053485332 cites W2131306815 @default.
- W2053485332 cites W2131721954 @default.
- W2053485332 cites W2135574023 @default.
- W2053485332 cites W2136176712 @default.
- W2053485332 cites W2139526755 @default.
- W2053485332 cites W2151224270 @default.
- W2053485332 cites W2153260785 @default.
- W2053485332 cites W2154583077 @default.
- W2053485332 cites W2159619477 @default.
- W2053485332 cites W2161110122 @default.
- W2053485332 cites W2163479859 @default.
- W2053485332 cites W2164720865 @default.
- W2053485332 cites W2327535659 @default.
- W2053485332 cites W2335362915 @default.
- W2053485332 cites W47368697 @default.
- W2053485332 doi "https://doi.org/10.1016/j.biomaterials.2013.09.098" @default.
- W2053485332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24125776" @default.
- W2053485332 hasPublicationYear "2014" @default.
- W2053485332 type Work @default.
- W2053485332 sameAs 2053485332 @default.
- W2053485332 citedByCount "96" @default.
- W2053485332 countsByYear W20534853322014 @default.
- W2053485332 countsByYear W20534853322015 @default.
- W2053485332 countsByYear W20534853322016 @default.
- W2053485332 countsByYear W20534853322017 @default.
- W2053485332 countsByYear W20534853322018 @default.
- W2053485332 countsByYear W20534853322019 @default.
- W2053485332 countsByYear W20534853322020 @default.
- W2053485332 countsByYear W20534853322021 @default.
- W2053485332 countsByYear W20534853322022 @default.
- W2053485332 countsByYear W20534853322023 @default.
- W2053485332 crossrefType "journal-article" @default.
- W2053485332 hasAuthorship W2053485332A5011492361 @default.
- W2053485332 hasAuthorship W2053485332A5039254367 @default.
- W2053485332 hasAuthorship W2053485332A5043093852 @default.
- W2053485332 hasAuthorship W2053485332A5044166963 @default.
- W2053485332 hasAuthorship W2053485332A5065145945 @default.
- W2053485332 hasAuthorship W2053485332A5071177970 @default.
- W2053485332 hasAuthorship W2053485332A5072979414 @default.
- W2053485332 hasAuthorship W2053485332A5085578187 @default.
- W2053485332 hasConcept C150903083 @default.
- W2053485332 hasConcept C161790260 @default.
- W2053485332 hasConcept C171250308 @default.
- W2053485332 hasConcept C185592680 @default.
- W2053485332 hasConcept C190283241 @default.