Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053487887> ?p ?o ?g. }
- W2053487887 abstract "The discovery of gene mutations underlying autosomal dominant Alzheimer’s disease has enabled researchers to reproduce several hallmarks of this disorder in transgenic mice, notably the formation of Aβ plaques in brain and cognitive deficits. APP transgenic mutants have also been investigated with respect to survival rates, neurologic functions, and motor coordination, which are all susceptible to alteration in Alzheimer dementia. Several transgenic lines expressing human mutated or wild-type APP had higher mortality rates than non-transgenic controls with or without the presence of Aβ plaques. Mortality rates were also elevated in APP transgenic mice with vascular amyloid accumulation, thereby implicating cerebrovascular factors in the precocious death observed in all APP transgenic models. In addition, myoclonic jumping has been described in APP mutants, together with seizure activity, abnormal limb-flexion and paw-clasping reflexes, and motor coordination deficits. The neurologic signs resemble the myoclonic movements, epileptic seizures, pathological reflexes, and gait problems observed in late-stage Alzheimer’s disease." @default.
- W2053487887 created "2016-06-24" @default.
- W2053487887 creator A5001725894 @default.
- W2053487887 creator A5011054353 @default.
- W2053487887 creator A5074570320 @default.
- W2053487887 date "2012-01-01" @default.
- W2053487887 modified "2023-10-08" @default.
- W2053487887 title "Neurologic and motor dysfunctions in APP transgenic mice" @default.
- W2053487887 cites W1228255293 @default.
- W2053487887 cites W144522987 @default.
- W2053487887 cites W1490666291 @default.
- W2053487887 cites W1511142149 @default.
- W2053487887 cites W1512881390 @default.
- W2053487887 cites W1527483808 @default.
- W2053487887 cites W1540067873 @default.
- W2053487887 cites W1546620272 @default.
- W2053487887 cites W154756152 @default.
- W2053487887 cites W1549342808 @default.
- W2053487887 cites W1584834830 @default.
- W2053487887 cites W1619610860 @default.
- W2053487887 cites W1738253268 @default.
- W2053487887 cites W181282724 @default.
- W2053487887 cites W1884657117 @default.
- W2053487887 cites W1886575365 @default.
- W2053487887 cites W1929267935 @default.
- W2053487887 cites W1964108234 @default.
- W2053487887 cites W1964747897 @default.
- W2053487887 cites W1965275873 @default.
- W2053487887 cites W1967464880 @default.
- W2053487887 cites W1968780740 @default.
- W2053487887 cites W1969424555 @default.
- W2053487887 cites W1969494696 @default.
- W2053487887 cites W1970029471 @default.
- W2053487887 cites W1971199242 @default.
- W2053487887 cites W1972067663 @default.
- W2053487887 cites W1972784541 @default.
- W2053487887 cites W1972850922 @default.
- W2053487887 cites W1974311360 @default.
- W2053487887 cites W1980432511 @default.
- W2053487887 cites W1981288814 @default.
- W2053487887 cites W1982126261 @default.
- W2053487887 cites W1983670592 @default.
- W2053487887 cites W1984865373 @default.
- W2053487887 cites W1988664372 @default.
- W2053487887 cites W1989453879 @default.
- W2053487887 cites W1990272771 @default.
- W2053487887 cites W1991155688 @default.
- W2053487887 cites W1991435932 @default.
- W2053487887 cites W1991838815 @default.
- W2053487887 cites W1992484817 @default.
- W2053487887 cites W1994101711 @default.
- W2053487887 cites W1995344309 @default.
- W2053487887 cites W1995397757 @default.
- W2053487887 cites W1995426930 @default.
- W2053487887 cites W1996447834 @default.
- W2053487887 cites W1997770523 @default.
- W2053487887 cites W1998659362 @default.
- W2053487887 cites W1998764391 @default.
- W2053487887 cites W1999234381 @default.
- W2053487887 cites W1999717818 @default.
- W2053487887 cites W2001210466 @default.
- W2053487887 cites W2002156069 @default.
- W2053487887 cites W2002757168 @default.
- W2053487887 cites W2003320905 @default.
- W2053487887 cites W2004852048 @default.
- W2053487887 cites W2005681172 @default.
- W2053487887 cites W2005719973 @default.
- W2053487887 cites W2005766463 @default.
- W2053487887 cites W2006843327 @default.
- W2053487887 cites W2009799196 @default.
- W2053487887 cites W2012921227 @default.
- W2053487887 cites W2013666305 @default.
- W2053487887 cites W2014155195 @default.
- W2053487887 cites W2016811754 @default.
- W2053487887 cites W2017429750 @default.
- W2053487887 cites W2017756285 @default.
- W2053487887 cites W2022460188 @default.
- W2053487887 cites W2023890923 @default.
- W2053487887 cites W2025962813 @default.
- W2053487887 cites W2026060908 @default.
- W2053487887 cites W2026119731 @default.
- W2053487887 cites W2026536207 @default.
- W2053487887 cites W2026883397 @default.
- W2053487887 cites W2030100345 @default.
- W2053487887 cites W2030336791 @default.
- W2053487887 cites W2034504333 @default.
- W2053487887 cites W2037129823 @default.
- W2053487887 cites W2042069812 @default.
- W2053487887 cites W2042794149 @default.
- W2053487887 cites W2045170182 @default.
- W2053487887 cites W2046137548 @default.
- W2053487887 cites W2049144486 @default.
- W2053487887 cites W2053139195 @default.
- W2053487887 cites W2054388625 @default.
- W2053487887 cites W2054802037 @default.
- W2053487887 cites W2055531981 @default.
- W2053487887 cites W2055667558 @default.
- W2053487887 cites W2056790002 @default.
- W2053487887 cites W2059157160 @default.
- W2053487887 cites W2059421321 @default.