Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053494630> ?p ?o ?g. }
- W2053494630 endingPage "288" @default.
- W2053494630 startingPage "271" @default.
- W2053494630 abstract "Neurotrophins and their cognate receptors are critical to normal nervous system development. Trk receptors are high-affinity receptors for nerve-growth factor (trkA), brain-derived neurotrophic factor and neurotrophin-4/5 (trkB), and neurotrophin-3 (trkC). We examine the expression of these three neurotrophin tyrosine kinase receptors in the chick auditory system throughout most of development. Trks were localized in the auditory brainstem, the cochlear ganglion, and the basilar papilla of chicks from embryonic (E) day 5 to E21, by using antibodies and standard immunocytochemical methods. TrkB mRNA was localized in brainstem nuclei by in situ hybridization.TrkB and trkC are highly expressed in the embryonic auditory brainstem, and their patterns of expression are both spatially and temporally dynamic. During early brainstem development, trkB and trkC are localized in the neuronal cell bodies and in the surrounding neuropil of nucleus magnocellularis (NM) and nucleus laminaris (NL). During later development, trkC is expressed in the cell bodies of NM and NL, whereas trkB is expressed in the nerve calyces surrounding NM neurons and in the ventral, but not the dorsal, dendrites of NL. In the periphery, trkB and trkC are located in the cochlear ganglion neurons and in peripheral fibers innervating the basilar papilla and synapsing at the base of hair cells.The protracted expression of trks seen in our materials is consistent with the hypothesis that the neurotrophins/tyrosine kinase receptors play one or several roles in the development of auditory circuitry. In particular, the polarized expression of trkB in NL is coincident with refinement of NM terminal arborizations on NL. J. Comp. Neurol. 413:271–288, 1999. © 1999 Wiley-Liss, Inc." @default.
- W2053494630 created "2016-06-24" @default.
- W2053494630 creator A5010851453 @default.
- W2053494630 creator A5012988440 @default.
- W2053494630 creator A5014848496 @default.
- W2053494630 creator A5061400673 @default.
- W2053494630 creator A5078745231 @default.
- W2053494630 creator A5090786305 @default.
- W2053494630 date "1999-10-18" @default.
- W2053494630 modified "2023-10-11" @default.
- W2053494630 title "Ontogenetic expression of trk neurotrophin receptors in the chick auditory system" @default.
- W2053494630 cites W1491409303 @default.
- W2053494630 cites W1496088120 @default.
- W2053494630 cites W1501115822 @default.
- W2053494630 cites W1539896698 @default.
- W2053494630 cites W1555506001 @default.
- W2053494630 cites W1611891438 @default.
- W2053494630 cites W1780057589 @default.
- W2053494630 cites W1783473189 @default.
- W2053494630 cites W1878010782 @default.
- W2053494630 cites W1924838141 @default.
- W2053494630 cites W1951802359 @default.
- W2053494630 cites W1956227640 @default.
- W2053494630 cites W1963657024 @default.
- W2053494630 cites W1964089660 @default.
- W2053494630 cites W1965884916 @default.
- W2053494630 cites W1966268438 @default.
- W2053494630 cites W1966949038 @default.
- W2053494630 cites W1967873137 @default.
- W2053494630 cites W1970697724 @default.
- W2053494630 cites W1971776075 @default.
- W2053494630 cites W1973736665 @default.
- W2053494630 cites W1974899939 @default.
- W2053494630 cites W1977127255 @default.
- W2053494630 cites W1977745877 @default.
- W2053494630 cites W1979305117 @default.
- W2053494630 cites W1981780292 @default.
- W2053494630 cites W1985724063 @default.
- W2053494630 cites W1987407476 @default.
- W2053494630 cites W1989053030 @default.
- W2053494630 cites W1989099240 @default.
- W2053494630 cites W1992428626 @default.
- W2053494630 cites W1995341304 @default.
- W2053494630 cites W1995374378 @default.
- W2053494630 cites W2001401457 @default.
- W2053494630 cites W2002945532 @default.
- W2053494630 cites W2004589166 @default.
- W2053494630 cites W2005024467 @default.
- W2053494630 cites W2005558197 @default.
- W2053494630 cites W2006683517 @default.
- W2053494630 cites W2008225455 @default.
- W2053494630 cites W2008904226 @default.
- W2053494630 cites W2009476128 @default.
- W2053494630 cites W2013558874 @default.
- W2053494630 cites W2014797861 @default.
- W2053494630 cites W2015689093 @default.
- W2053494630 cites W2017691905 @default.
- W2053494630 cites W2020351428 @default.
- W2053494630 cites W2022180780 @default.
- W2053494630 cites W2024014699 @default.
- W2053494630 cites W2024421127 @default.
- W2053494630 cites W2027696867 @default.
- W2053494630 cites W2030755571 @default.
- W2053494630 cites W2036515774 @default.
- W2053494630 cites W2036639063 @default.
- W2053494630 cites W2037055372 @default.
- W2053494630 cites W2038702076 @default.
- W2053494630 cites W2039475563 @default.
- W2053494630 cites W2044015089 @default.
- W2053494630 cites W2045025597 @default.
- W2053494630 cites W2046473105 @default.
- W2053494630 cites W2048121291 @default.
- W2053494630 cites W2048524183 @default.
- W2053494630 cites W2048838375 @default.
- W2053494630 cites W2049110585 @default.
- W2053494630 cites W2049128931 @default.
- W2053494630 cites W2050120071 @default.
- W2053494630 cites W2054595326 @default.
- W2053494630 cites W2055149392 @default.
- W2053494630 cites W2055566482 @default.
- W2053494630 cites W2056495451 @default.
- W2053494630 cites W2058479911 @default.
- W2053494630 cites W2063695629 @default.
- W2053494630 cites W2066790769 @default.
- W2053494630 cites W2067105964 @default.
- W2053494630 cites W2069166075 @default.
- W2053494630 cites W2074345277 @default.
- W2053494630 cites W2075688985 @default.
- W2053494630 cites W2076894554 @default.
- W2053494630 cites W2079231516 @default.
- W2053494630 cites W2079350959 @default.
- W2053494630 cites W2080136448 @default.
- W2053494630 cites W2081555648 @default.
- W2053494630 cites W2082311145 @default.
- W2053494630 cites W2082739481 @default.
- W2053494630 cites W2086896307 @default.
- W2053494630 cites W2088408030 @default.
- W2053494630 cites W2091024750 @default.