Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053495763> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2053495763 endingPage "709" @default.
- W2053495763 startingPage "704" @default.
- W2053495763 abstract "Gadd45a is a p53-regulated gene whose protein product, like p53, is involved in maintenanceof genome stability. Specifically, deletion of Gadd45a leads to extensive aneuploidy as aconsequence of centrosome amplification and subsequent abnormal segregation of chromosomesduring mitosis. S-phase checkpoints were investigated in Gadd45a-/- cells to determine possibledefects contributing to the uncoupling of centrosome duplication and DNA replication. In thepresence of hydroxyurea, Gadd45a-/- mouse embryo fibroblasts show increased centrosomeamplification coupled with loss of a sustained S-phase checkpoint. Gadd45a deletion allowsanother form of genomic instability, gene amplification, when p21 (Cdkn1a gene product) isdeleted also. Gene amplification in Gadd45a-/-p21-/- cells correlated with loss of both G1 andS-phase checkpoints. Multiple conditions of nutrient deprivation failed to prevent DNAsynthesis in Gadd45a-/- cells. Gadd45a is therefore required for proper S-phase control andcheckpoints under multiple conditions of nutrient deprivation. It is proposed that loss of S-phasecontrol may account for both the uncoupling of DNA replication and centrosome duplication,and conferring gene amplification proficiency in cells lacking Gadd45a-/-. This is of particularimportance for solid tumors, which may lack sufficient nutrients yet are unable to elicitcheckpoints preventing genomic instability under these conditions." @default.
- W2053495763 created "2016-06-24" @default.
- W2053495763 creator A5067651226 @default.
- W2053495763 creator A5068942196 @default.
- W2053495763 creator A5072690626 @default.
- W2053495763 creator A5075033594 @default.
- W2053495763 creator A5080881343 @default.
- W2053495763 date "2005-03-02" @default.
- W2053495763 modified "2023-10-17" @default.
- W2053495763 title "Genomic Instability in <i>Gadd45a<sup>-/-</sup></i> Cells is Coupled with S-Phase Checkpoint Defects" @default.
- W2053495763 doi "https://doi.org/10.4161/cc.4.5.1675" @default.
- W2053495763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15846075" @default.
- W2053495763 hasPublicationYear "2005" @default.
- W2053495763 type Work @default.
- W2053495763 sameAs 2053495763 @default.
- W2053495763 citedByCount "17" @default.
- W2053495763 countsByYear W20534957632014 @default.
- W2053495763 countsByYear W20534957632016 @default.
- W2053495763 countsByYear W20534957632022 @default.
- W2053495763 crossrefType "journal-article" @default.
- W2053495763 hasAuthorship W2053495763A5067651226 @default.
- W2053495763 hasAuthorship W2053495763A5068942196 @default.
- W2053495763 hasAuthorship W2053495763A5072690626 @default.
- W2053495763 hasAuthorship W2053495763A5075033594 @default.
- W2053495763 hasAuthorship W2053495763A5080881343 @default.
- W2053495763 hasBestOaLocation W20534957631 @default.
- W2053495763 hasConcept C104317684 @default.
- W2053495763 hasConcept C10447061 @default.
- W2053495763 hasConcept C134935766 @default.
- W2053495763 hasConcept C140752955 @default.
- W2053495763 hasConcept C143425029 @default.
- W2053495763 hasConcept C153911025 @default.
- W2053495763 hasConcept C178169997 @default.
- W2053495763 hasConcept C29537977 @default.
- W2053495763 hasConcept C30481170 @default.
- W2053495763 hasConcept C54355233 @default.
- W2053495763 hasConcept C552990157 @default.
- W2053495763 hasConcept C73573662 @default.
- W2053495763 hasConcept C7602840 @default.
- W2053495763 hasConcept C86803240 @default.
- W2053495763 hasConcept C93304396 @default.
- W2053495763 hasConcept C95444343 @default.
- W2053495763 hasConceptScore W2053495763C104317684 @default.
- W2053495763 hasConceptScore W2053495763C10447061 @default.
- W2053495763 hasConceptScore W2053495763C134935766 @default.
- W2053495763 hasConceptScore W2053495763C140752955 @default.
- W2053495763 hasConceptScore W2053495763C143425029 @default.
- W2053495763 hasConceptScore W2053495763C153911025 @default.
- W2053495763 hasConceptScore W2053495763C178169997 @default.
- W2053495763 hasConceptScore W2053495763C29537977 @default.
- W2053495763 hasConceptScore W2053495763C30481170 @default.
- W2053495763 hasConceptScore W2053495763C54355233 @default.
- W2053495763 hasConceptScore W2053495763C552990157 @default.
- W2053495763 hasConceptScore W2053495763C73573662 @default.
- W2053495763 hasConceptScore W2053495763C7602840 @default.
- W2053495763 hasConceptScore W2053495763C86803240 @default.
- W2053495763 hasConceptScore W2053495763C93304396 @default.
- W2053495763 hasConceptScore W2053495763C95444343 @default.
- W2053495763 hasIssue "5" @default.
- W2053495763 hasLocation W20534957631 @default.
- W2053495763 hasLocation W20534957632 @default.
- W2053495763 hasOpenAccess W2053495763 @default.
- W2053495763 hasPrimaryLocation W20534957631 @default.
- W2053495763 hasRelatedWork W1140116790 @default.
- W2053495763 hasRelatedWork W1967149801 @default.
- W2053495763 hasRelatedWork W1995981964 @default.
- W2053495763 hasRelatedWork W2050511422 @default.
- W2053495763 hasRelatedWork W2084475506 @default.
- W2053495763 hasRelatedWork W2106373810 @default.
- W2053495763 hasRelatedWork W2134913787 @default.
- W2053495763 hasRelatedWork W2254262516 @default.
- W2053495763 hasRelatedWork W2352719856 @default.
- W2053495763 hasRelatedWork W4231845372 @default.
- W2053495763 hasVolume "4" @default.
- W2053495763 isParatext "false" @default.
- W2053495763 isRetracted "false" @default.
- W2053495763 magId "2053495763" @default.
- W2053495763 workType "article" @default.