Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053500854> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2053500854 endingPage "178" @default.
- W2053500854 startingPage "173" @default.
- W2053500854 abstract "This study was undertaken to investigate the stability of ascorbic acid and its primary degradation product, dehydroascorbic acid, in total parenteral nutrition (TPN) mixtures. The influence of the type of bag and the commercial source of amino acid on ascorbate degradation was examined, using a stability-indicating high-pressure liquid chromatography (HPLC) method. Ascorbic acid was most stable in multilayered bags, compared with ethylvinyl acetate (EVA) bags. Results indicated that, in multilayered bags, the initial rapid ascorbic acid degradation was greatest in TPN mixtures containing amino acid infusions without reducing activity. In contrast, degradation in TPN mixtures containing amino acids with reducing compounds (Vamin 14 and Freamine III 8.5%) was less than 10% of the added amount. Dehydroascorbic acid degraded approximately in parallel with ascorbic acid, and it contributed to the total available ascorbate activity. The addition of air to TPN mixtures in multilayered bags caused accelerated degradation of both ascorbic acid and dehydroascorbic acid. It is concluded that TPN mixtures compounded in multilayered bags can be safely assigned extended shelf lives, especially if compounded using an amino acid with reducing activity. This is principally due to the protective effect of the bag wall in preventing oxygen transmission, the cause of ascorbic acid oxidation, because oxygen transmission through the bag wall is minimized during storage. TPN mixtures stored in EVA bags should be administered within 2–4 d of compounding, depending on the amino acid infusion used." @default.
- W2053500854 created "2016-06-24" @default.
- W2053500854 creator A5017380700 @default.
- W2053500854 creator A5044742779 @default.
- W2053500854 creator A5050947383 @default.
- W2053500854 creator A5064037263 @default.
- W2053500854 creator A5076579470 @default.
- W2053500854 date "1998-02-01" @default.
- W2053500854 modified "2023-09-27" @default.
- W2053500854 title "The influence of amino acid source on the stability of ascorbic acid in TPN mixtures" @default.
- W2053500854 cites W1965940959 @default.
- W2053500854 cites W1987105695 @default.
- W2053500854 cites W2019327650 @default.
- W2053500854 cites W2024456582 @default.
- W2053500854 cites W2050726111 @default.
- W2053500854 cites W2071739909 @default.
- W2053500854 cites W2072009140 @default.
- W2053500854 cites W2081537316 @default.
- W2053500854 cites W2093001334 @default.
- W2053500854 cites W2141237599 @default.
- W2053500854 doi "https://doi.org/10.1016/s0899-9007(97)00430-9" @default.
- W2053500854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9530644" @default.
- W2053500854 hasPublicationYear "1998" @default.
- W2053500854 type Work @default.
- W2053500854 sameAs 2053500854 @default.
- W2053500854 citedByCount "17" @default.
- W2053500854 countsByYear W20535008542012 @default.
- W2053500854 countsByYear W20535008542014 @default.
- W2053500854 countsByYear W20535008542015 @default.
- W2053500854 countsByYear W20535008542018 @default.
- W2053500854 countsByYear W20535008542022 @default.
- W2053500854 crossrefType "journal-article" @default.
- W2053500854 hasAuthorship W2053500854A5017380700 @default.
- W2053500854 hasAuthorship W2053500854A5044742779 @default.
- W2053500854 hasAuthorship W2053500854A5050947383 @default.
- W2053500854 hasAuthorship W2053500854A5064037263 @default.
- W2053500854 hasAuthorship W2053500854A5076579470 @default.
- W2053500854 hasConcept C179998833 @default.
- W2053500854 hasConcept C185592680 @default.
- W2053500854 hasConcept C2779211342 @default.
- W2053500854 hasConcept C2779679103 @default.
- W2053500854 hasConcept C2986274086 @default.
- W2053500854 hasConcept C31903555 @default.
- W2053500854 hasConcept C41008148 @default.
- W2053500854 hasConcept C43617362 @default.
- W2053500854 hasConcept C515207424 @default.
- W2053500854 hasConcept C55493867 @default.
- W2053500854 hasConcept C76155785 @default.
- W2053500854 hasConceptScore W2053500854C179998833 @default.
- W2053500854 hasConceptScore W2053500854C185592680 @default.
- W2053500854 hasConceptScore W2053500854C2779211342 @default.
- W2053500854 hasConceptScore W2053500854C2779679103 @default.
- W2053500854 hasConceptScore W2053500854C2986274086 @default.
- W2053500854 hasConceptScore W2053500854C31903555 @default.
- W2053500854 hasConceptScore W2053500854C41008148 @default.
- W2053500854 hasConceptScore W2053500854C43617362 @default.
- W2053500854 hasConceptScore W2053500854C515207424 @default.
- W2053500854 hasConceptScore W2053500854C55493867 @default.
- W2053500854 hasConceptScore W2053500854C76155785 @default.
- W2053500854 hasIssue "2" @default.
- W2053500854 hasLocation W20535008541 @default.
- W2053500854 hasLocation W20535008542 @default.
- W2053500854 hasOpenAccess W2053500854 @default.
- W2053500854 hasPrimaryLocation W20535008541 @default.
- W2053500854 hasRelatedWork W139548325 @default.
- W2053500854 hasRelatedWork W1976905748 @default.
- W2053500854 hasRelatedWork W2030069278 @default.
- W2053500854 hasRelatedWork W2034837766 @default.
- W2053500854 hasRelatedWork W2036215735 @default.
- W2053500854 hasRelatedWork W2065377794 @default.
- W2053500854 hasRelatedWork W2074719530 @default.
- W2053500854 hasRelatedWork W2086107997 @default.
- W2053500854 hasRelatedWork W2094646195 @default.
- W2053500854 hasRelatedWork W2363179112 @default.
- W2053500854 hasVolume "14" @default.
- W2053500854 isParatext "false" @default.
- W2053500854 isRetracted "false" @default.
- W2053500854 magId "2053500854" @default.
- W2053500854 workType "article" @default.