Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053510002> ?p ?o ?g. }
- W2053510002 endingPage "650" @default.
- W2053510002 startingPage "640" @default.
- W2053510002 abstract "Abstract Osteopontin is a protein found in the bone‐related matrix and plays multiple regulatory roles in mineralizing and non‐mineralizing tissue. In osteogenic cell‐lines, the expression of osteopontin increases with the progression of differentiation, but both the expression and function of osteopontin vary with the cell type and its activation state. In this study, we examined the expression of osteopontin by clones established from mouse periodontal ligament, in response to inorganic phosphate and fibroblast growth factor (FGF)‐2, which can induce periodontal tissue regeneration. The involvement of inorganic phosphate in the expression of osteopontin during the course of cell differentiation of a clone MPDL22 was confirmed by addition of foscarnet, an inorganic phosphate transport inhibitor. Although FGF‐2 decreased the mRNA expression of almost every bone‐related protein in MPDL22, FGF‐2 upregulated the expression of osteopontin in MPDL22 at both mRNA and protein levels. Interestingly, FGF‐2 enhanced the concentration of osteopontin in the culture supernatant of MPDL22, whereas inorganic phosphate did not. The FGF‐2‐induced osteopontin in the culture supernatant seems to be involved in cell survival activity. An immunohistochemical study showed that the FGF‐2‐induced osteopontin was mainly present in perinuclear matrices while the inorganic phosphate‐induced osteopontin was associated with extracellular matrices in addition to perinuclear matrices. The present results indicated that FGF‐2 induces unique expression of osteopontin, which may play a role different from the other bone‐related proteins during the process of periodontal tissue regeneration by FGF‐2. J. Cell. Physiol. 216: 640–650, 2008, © 2008 Wiley‐Liss, Inc." @default.
- W2053510002 created "2016-06-24" @default.
- W2053510002 creator A5002282707 @default.
- W2053510002 creator A5002445778 @default.
- W2053510002 creator A5013242339 @default.
- W2053510002 creator A5021086508 @default.
- W2053510002 creator A5028681920 @default.
- W2053510002 creator A5040562777 @default.
- W2053510002 creator A5042011354 @default.
- W2053510002 creator A5044665174 @default.
- W2053510002 creator A5046060050 @default.
- W2053510002 creator A5062313883 @default.
- W2053510002 creator A5079021971 @default.
- W2053510002 date "2008-04-15" @default.
- W2053510002 modified "2023-10-16" @default.
- W2053510002 title "Fibroblast growth factor‐2 regulates expression of osteopontin in periodontal ligament cells" @default.
- W2053510002 cites W1482609495 @default.
- W2053510002 cites W1540384225 @default.
- W2053510002 cites W1564926555 @default.
- W2053510002 cites W1594802667 @default.
- W2053510002 cites W1599513095 @default.
- W2053510002 cites W1716523897 @default.
- W2053510002 cites W1784982965 @default.
- W2053510002 cites W1939982746 @default.
- W2053510002 cites W1967313614 @default.
- W2053510002 cites W1968687955 @default.
- W2053510002 cites W1972674412 @default.
- W2053510002 cites W1977779461 @default.
- W2053510002 cites W1979164076 @default.
- W2053510002 cites W1982316075 @default.
- W2053510002 cites W1983529229 @default.
- W2053510002 cites W1985691031 @default.
- W2053510002 cites W1985908016 @default.
- W2053510002 cites W1988247155 @default.
- W2053510002 cites W1988711824 @default.
- W2053510002 cites W1991953529 @default.
- W2053510002 cites W2004994163 @default.
- W2053510002 cites W2006795933 @default.
- W2053510002 cites W2006877529 @default.
- W2053510002 cites W2008675789 @default.
- W2053510002 cites W2009025335 @default.
- W2053510002 cites W2014097308 @default.
- W2053510002 cites W2014571318 @default.
- W2053510002 cites W2014732354 @default.
- W2053510002 cites W2021480619 @default.
- W2053510002 cites W2023888084 @default.
- W2053510002 cites W2034378488 @default.
- W2053510002 cites W2045217259 @default.
- W2053510002 cites W2045919114 @default.
- W2053510002 cites W2051180982 @default.
- W2053510002 cites W2053110895 @default.
- W2053510002 cites W2053135187 @default.
- W2053510002 cites W2053867930 @default.
- W2053510002 cites W2057616292 @default.
- W2053510002 cites W2057929092 @default.
- W2053510002 cites W2058070157 @default.
- W2053510002 cites W2059314014 @default.
- W2053510002 cites W2062444305 @default.
- W2053510002 cites W2063688108 @default.
- W2053510002 cites W2063816044 @default.
- W2053510002 cites W2064720560 @default.
- W2053510002 cites W2068819752 @default.
- W2053510002 cites W2077038946 @default.
- W2053510002 cites W2077792312 @default.
- W2053510002 cites W2086002212 @default.
- W2053510002 cites W2086643928 @default.
- W2053510002 cites W2088059979 @default.
- W2053510002 cites W2089794703 @default.
- W2053510002 cites W2090078700 @default.
- W2053510002 cites W2092273695 @default.
- W2053510002 cites W2094860694 @default.
- W2053510002 cites W2107704767 @default.
- W2053510002 cites W2115537515 @default.
- W2053510002 cites W2119508007 @default.
- W2053510002 cites W2121868164 @default.
- W2053510002 cites W2122358120 @default.
- W2053510002 cites W2129953156 @default.
- W2053510002 cites W2132427518 @default.
- W2053510002 cites W2134541063 @default.
- W2053510002 cites W2134771161 @default.
- W2053510002 cites W2135321183 @default.
- W2053510002 cites W2137801669 @default.
- W2053510002 cites W2140334975 @default.
- W2053510002 cites W2144224215 @default.
- W2053510002 cites W2150989762 @default.
- W2053510002 cites W2156275876 @default.
- W2053510002 cites W2161512797 @default.
- W2053510002 cites W2165916469 @default.
- W2053510002 cites W2334845479 @default.
- W2053510002 cites W2346692519 @default.
- W2053510002 doi "https://doi.org/10.1002/jcp.21443" @default.
- W2053510002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18412142" @default.
- W2053510002 hasPublicationYear "2008" @default.
- W2053510002 type Work @default.
- W2053510002 sameAs 2053510002 @default.
- W2053510002 citedByCount "33" @default.
- W2053510002 countsByYear W20535100022012 @default.
- W2053510002 countsByYear W20535100022013 @default.