FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053519812> ?p ?o ?g. }

• W2053519812 endingPage "1681" @default.
• W2053519812 startingPage "1675" @default.
• W2053519812 abstract "Prolyl 3-hydroxylase 1 (P3H1), cartilage-associated protein (CRTAP) and cyclophilin B (CyPB) form a complex in the endoplasmic reticulum which is responsible for 3-hydroxylation of a limited number of proline residues in types I, II and V collagens. In this complex, CRTAP serves the role of helper protein, while P3H1 provides the enzymatic activity for the modification. In type I collagen, the major protein of the extracellular matrix of bone, the complex 3-hydroxylates only the a1(I)Pro986 residue. P3H1 and CRTAP each also have independent roles as components of matrix. Furthermore, the two proteins have significant homology with each other. The critical importance of the components of the complex for normal bone development has been revealed by a Crtap knock-out mouse and by infants and children with null mutations of CRTAP and LEPRE1, the gene that encodes P3H1. On a clinical level, defects in the components of the prolyl 3-hydroxylation complex have been shown to be the long-sought cause of severe and lethal recessive osteogenesis imperfecta." @default.
• W2053519812 created "2016-06-24" @default.
• W2053519812 creator A5010087856 @default.
• W2053519812 creator A5023280488 @default.
• W2053519812 creator A5024925022 @default.
• W2053519812 creator A5043449663 @default.
• W2053519812 date "2007-07-15" @default.
• W2053519812 modified "2023-10-10" @default.
• W2053519812 title "Components of the Collagen Prolyl 3-Hydroxylation Complex are Crucial for Normal Bone Development" @default.
• W2053519812 cites W1523963881 @default.
• W2053519812 cites W1585340447 @default.
• W2053519812 cites W1587602433 @default.
• W2053519812 cites W1588317987 @default.
• W2053519812 cites W1591215074 @default.
• W2053519812 cites W1593096309 @default.
• W2053519812 cites W1969051840 @default.
• W2053519812 cites W1973528370 @default.
• W2053519812 cites W1978162436 @default.
• W2053519812 cites W1984577233 @default.
• W2053519812 cites W1989936089 @default.
• W2053519812 cites W1991453189 @default.
• W2053519812 cites W1994998604 @default.
• W2053519812 cites W1995869907 @default.
• W2053519812 cites W2003305541 @default.
• W2053519812 cites W2004347556 @default.
• W2053519812 cites W2006931104 @default.
• W2053519812 cites W2027637600 @default.
• W2053519812 cites W2038610854 @default.
• W2053519812 cites W2051068162 @default.
• W2053519812 cites W2062120260 @default.
• W2053519812 cites W2062139927 @default.
• W2053519812 cites W2069566684 @default.
• W2053519812 cites W2072863928 @default.
• W2053519812 cites W2082454321 @default.
• W2053519812 cites W2086486681 @default.
• W2053519812 cites W2087623868 @default.
• W2053519812 cites W2096915982 @default.
• W2053519812 cites W2102186164 @default.
• W2053519812 cites W2109276727 @default.
• W2053519812 cites W2121034018 @default.
• W2053519812 cites W2131581447 @default.
• W2053519812 cites W2154974204 @default.
• W2053519812 cites W2166837353 @default.
• W2053519812 cites W2188898809 @default.
• W2053519812 cites W2326795245 @default.
• W2053519812 cites W2787992352 @default.
• W2053519812 doi "https://doi.org/10.4161/cc.6.14.4474" @default.
• W2053519812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17630507" @default.
• W2053519812 hasPublicationYear "2007" @default.
• W2053519812 type Work @default.
• W2053519812 sameAs 2053519812 @default.
• W2053519812 citedByCount "101" @default.
• W2053519812 countsByYear W20535198122012 @default.
• W2053519812 countsByYear W20535198122013 @default.
• W2053519812 countsByYear W20535198122014 @default.
• W2053519812 countsByYear W20535198122015 @default.
• W2053519812 countsByYear W20535198122016 @default.
• W2053519812 countsByYear W20535198122017 @default.
• W2053519812 countsByYear W20535198122018 @default.
• W2053519812 countsByYear W20535198122019 @default.
• W2053519812 countsByYear W20535198122020 @default.
• W2053519812 countsByYear W20535198122021 @default.
• W2053519812 countsByYear W20535198122022 @default.
• W2053519812 countsByYear W20535198122023 @default.
• W2053519812 crossrefType "journal-article" @default.
• W2053519812 hasAuthorship W2053519812A5010087856 @default.
• W2053519812 hasAuthorship W2053519812A5023280488 @default.
• W2053519812 hasAuthorship W2053519812A5024925022 @default.
• W2053519812 hasAuthorship W2053519812A5043449663 @default.
• W2053519812 hasBestOaLocation W20535198121 @default.
• W2053519812 hasConcept C104317684 @default.
• W2053519812 hasConcept C105702510 @default.
• W2053519812 hasConcept C134018914 @default.
• W2053519812 hasConcept C158617107 @default.
• W2053519812 hasConcept C181199279 @default.
• W2053519812 hasConcept C189165786 @default.
• W2053519812 hasConcept C2776326521 @default.
• W2053519812 hasConcept C2777668750 @default.
• W2053519812 hasConcept C2780644872 @default.
• W2053519812 hasConcept C2781109383 @default.
• W2053519812 hasConcept C54355233 @default.
• W2053519812 hasConcept C55493867 @default.
• W2053519812 hasConcept C86803240 @default.
• W2053519812 hasConcept C95444343 @default.
• W2053519812 hasConceptScore W2053519812C104317684 @default.
• W2053519812 hasConceptScore W2053519812C105702510 @default.
• W2053519812 hasConceptScore W2053519812C134018914 @default.
• W2053519812 hasConceptScore W2053519812C158617107 @default.
• W2053519812 hasConceptScore W2053519812C181199279 @default.
• W2053519812 hasConceptScore W2053519812C189165786 @default.
• W2053519812 hasConceptScore W2053519812C2776326521 @default.
• W2053519812 hasConceptScore W2053519812C2777668750 @default.
• W2053519812 hasConceptScore W2053519812C2780644872 @default.
• W2053519812 hasConceptScore W2053519812C2781109383 @default.
• W2053519812 hasConceptScore W2053519812C54355233 @default.
• W2053519812 hasConceptScore W2053519812C55493867 @default.
• W2053519812 hasConceptScore W2053519812C86803240 @default.
• W2053519812 hasConceptScore W2053519812C95444343 @default.

• next