FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053520328> ?p ?o ?g. }

• W2053520328 endingPage "291" @default.
• W2053520328 startingPage "261" @default.
• W2053520328 abstract "This article outlines the principles of radiobiology that can explain the time of onset, duration, and severity of the complex reactions of the lung to ionizing radiation. These reactions have been assayed biochemically, cell kinetically, physiologically, and pathologically. Clinical and experimental data are used to describe the acute and late reactions of the lung to both external and internal radiation including pneumonitis, fibrosis and carcinogenesis. Acute radiation pneumonitis, which can be fatal, develops in both humans and animals within 6 months of exposure to doses greater than or equal to 8 Gy of low LET radiation. It is divisible into a latent period lasting up to 4 weeks; an exudative phase (3-8 weeks) and with an acute pneumonitic phase between 2 and 6 months. The latter is an inflammatory reaction with intra-alveolar and septal edema accompanied by epithelial and endothelial desquamation. The critical role of type II pneumonocytes is discussed. One favored hypothesis suggests that the primary response of the lung is an increase in microvascular permeability. The plasma proteins overwhelm the lymphatic and other drainage mechanisms and this elicits the secondary response of type II cell hyperplasia. This, in its turn, produces an excess of surfactant that ultimately causes the fall in compliance, abnormal gas exchange values, and even respiratory failure. The inflammatory early reaction may progress to chronic fibrosis. There is much evidence to suggest that pneumonitis is an epithelial reaction and some evidence to suggest that this early damage may not be predictive of late fibrosis. However, despite detailed work on collagen metabolism, the pathogenesis of radiation fibrosis remains unknown. The data on radiation-induced pulmonary cancer, both in man and experimental animals from both external and internal irradiation following the inhalation of both soluble and insoluble alpha and beta emitting radionuclides are reviewed. Emphasis is placed on the data showing that alpha emitters are at least an order of magnitude more hazardous than beta/gamma radiation and on recent data showing that the more homogeneous the irradiation of the lung, the greater is the carcinogenic hazard which contradicts the so-called hot particle theory." @default.
• W2053520328 created "2016-06-24" @default.
• W2053520328 creator A5020888727 @default.
• W2053520328 creator A5033498806 @default.
• W2053520328 creator A5043528095 @default.
• W2053520328 date "1986-12-01" @default.
• W2053520328 modified "2023-10-16" @default.
• W2053520328 title "Radiation effects in the lung." @default.
• W2053520328 cites W108914524 @default.
• W2053520328 cites W124195097 @default.
• W2053520328 cites W124673354 @default.
• W2053520328 cites W139719473 @default.
• W2053520328 cites W1480816266 @default.
• W2053520328 cites W1495696889 @default.
• W2053520328 cites W1519824669 @default.
• W2053520328 cites W1551593332 @default.
• W2053520328 cites W1552273687 @default.
• W2053520328 cites W157269211 @default.
• W2053520328 cites W1572783053 @default.
• W2053520328 cites W1578207088 @default.
• W2053520328 cites W1580887576 @default.
• W2053520328 cites W1591556736 @default.
• W2053520328 cites W1602595073 @default.
• W2053520328 cites W162329084 @default.
• W2053520328 cites W1646869513 @default.
• W2053520328 cites W170072813 @default.
• W2053520328 cites W1875262562 @default.
• W2053520328 cites W1887417738 @default.
• W2053520328 cites W1889909247 @default.
• W2053520328 cites W1915631181 @default.
• W2053520328 cites W1964082076 @default.
• W2053520328 cites W1964624837 @default.
• W2053520328 cites W1965413887 @default.
• W2053520328 cites W1965589173 @default.
• W2053520328 cites W1966556526 @default.
• W2053520328 cites W1967433693 @default.
• W2053520328 cites W1970417680 @default.
• W2053520328 cites W1970889878 @default.
• W2053520328 cites W1975550858 @default.
• W2053520328 cites W1976100298 @default.
• W2053520328 cites W1977065327 @default.
• W2053520328 cites W1980646113 @default.
• W2053520328 cites W1982120410 @default.
• W2053520328 cites W1982716481 @default.
• W2053520328 cites W1982847584 @default.
• W2053520328 cites W1983339282 @default.
• W2053520328 cites W1984920039 @default.
• W2053520328 cites W1985596112 @default.
• W2053520328 cites W1987444332 @default.
• W2053520328 cites W1988024604 @default.
• W2053520328 cites W1988695187 @default.
• W2053520328 cites W1989484101 @default.
• W2053520328 cites W1990316630 @default.
• W2053520328 cites W1990635277 @default.
• W2053520328 cites W1992664447 @default.
• W2053520328 cites W1993743230 @default.
• W2053520328 cites W1994507509 @default.
• W2053520328 cites W1994750400 @default.
• W2053520328 cites W1995076582 @default.
• W2053520328 cites W1995442474 @default.
• W2053520328 cites W1996068179 @default.
• W2053520328 cites W1996933057 @default.
• W2053520328 cites W1997529869 @default.
• W2053520328 cites W1999725191 @default.
• W2053520328 cites W2000272786 @default.
• W2053520328 cites W2000885290 @default.
• W2053520328 cites W2001673178 @default.
• W2053520328 cites W2002180325 @default.
• W2053520328 cites W2002184229 @default.
• W2053520328 cites W2003314004 @default.
• W2053520328 cites W2003606201 @default.
• W2053520328 cites W2004787426 @default.
• W2053520328 cites W2005657123 @default.
• W2053520328 cites W2006265006 @default.
• W2053520328 cites W2006687511 @default.
• W2053520328 cites W2007010802 @default.
• W2053520328 cites W2007753350 @default.
• W2053520328 cites W2008485138 @default.
• W2053520328 cites W2009236102 @default.
• W2053520328 cites W2012107740 @default.
• W2053520328 cites W2016785308 @default.
• W2053520328 cites W2019859553 @default.
• W2053520328 cites W2025913924 @default.
• W2053520328 cites W2027388344 @default.
• W2053520328 cites W2028558688 @default.
• W2053520328 cites W2030819118 @default.
• W2053520328 cites W2031334634 @default.
• W2053520328 cites W2031831299 @default.
• W2053520328 cites W2033508478 @default.
• W2053520328 cites W2039040659 @default.
• W2053520328 cites W2041288463 @default.
• W2053520328 cites W2044967143 @default.
• W2053520328 cites W2045747367 @default.
• W2053520328 cites W2047417154 @default.
• W2053520328 cites W2049982112 @default.
• W2053520328 cites W2050120039 @default.
• W2053520328 cites W2057551069 @default.
• W2053520328 cites W2057943031 @default.

• next