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- W20535288 abstract "Clinical strategy in chemotherapy of gastrointestinal cancer depends on availability of drugs with single-agent activity. If active drugs are available, combination chemotherapy trials can be developed. In gastric cancer, combinations of 5-fluorouracil with chloroethyl nitrosoureas or adriamycin and mitomycin C are capable of producing responses in 40-50% of patients. Such active combinations may now be evaluated in patients with less advanced gastric carcinoma. The role of combination chemotherapy is now being defined in patients with locally unresectable cancer and in the surgical adjuvant situation. In pancreatic and colorectal cancer, combination chemotherapy regimens have been of marginal effectiveness. The major thrust of clinical investigation must be directed toward phase II evaluations of single agents in these diseases." @default.
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- W20535288 date "1980-01-01" @default.
- W20535288 modified "2023-09-27" @default.
- W20535288 title "Clinical Strategies in the Chemotherapy of Gastrointestinal Cancer" @default.
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- W20535288 doi "https://doi.org/10.1007/978-3-642-81392-4_19" @default.
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