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- W2053552405 abstract "Some organic anions and lithocholate-3-O-glucuronide have been reported to inhibit biliary glutathione excretion. In this study the effect of lithocholate-3-sulfate on biliary glutathione excretion was examined in rats. Furthermore, the effects of its amides on biliary glutathione and phospholipid excretion were also studied. Intravenously injected lithocholate-3-sulfate (3 μmol/100 g body wt.) depressed biliary glutathione excretion to 15% of the basal value, which corresponded to biliary lithocholate-3-sulfate excretion. The same dose of glyco- and taurolithocholate-3-sulfate also inhibited biliary glutathione excretion, and its inhibition was more marked with glycolithocholate-3-sulfate. In contrast, taurolithocholate-3-sulfate increased the bile acid/phospholipid ratio in the bile more markedly than glycolithocholate-3-sulfate did. These findings indicate that the mechanisms for inhibition by lithocholate-3-sulfate amides of biliary excretion of glutathione and phospholipid are different." @default.
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- W2053552405 date "1996-02-01" @default.
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- W2053552405 title "Effect of lithocholate-3-sulfate and its amides on biliary excretion of glutathione and phospholipid" @default.
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- W2053552405 doi "https://doi.org/10.1016/0928-4346(96)00254-x" @default.
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