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- W2053552486 abstract "The scale of depression in patients with chronic liver disease (CLD) and those who have received orthotopic liver transplantation (OLT) is poorly characterised. Clinicians are uncertain of how best to manage depression within these patients.To review the literature evaluating both the prevalence and impact of depression in patients with CLD and post-OLT, and to assess the safety and efficacy of antidepressant use within this context.A PubMed search using the phrases 'chronic liver disease', 'cirrhosis', 'liver transplantation', 'depression', 'antidepressant' and the names of specific causes of liver disease and individual antidepressants.Over 30% of cirrhotic patients have depressive features, and they experience worse clinical outcomes than nondepressed cirrhotic patients. CLD patients with chronic hepatitis C are particularly prone to depression, partly related to the use of interferon therapy. OLT patients with depression have higher mortality rates than nondepressed patients; appropriate antidepressant use reverses this effect. Selective serotonin reuptake inhibitors (SSRIs) and selective noradrenaline reuptake inhibitors (SNRIs) are effective and generally safe in both CLD and OLT patients.Depression is much more prevalent in CLD or OLT patients than is generally recognised, and it adversely affects clinical outcomes. The reasons for this relationship are complex and multifactorial. Antidepressants are effective in both CLD and post-OLT, although lower doses or a reduced dosing frequency may be required to minimise side effects, e.g. exacerbation of hepatic encephalopathy. Further research is needed to establish optimal management of depression in these patients, including the potential role of nonpharmacological treatments." @default.
- W2053552486 created "2016-06-24" @default.
- W2053552486 creator A5003295866 @default.
- W2053552486 creator A5023606749 @default.
- W2053552486 creator A5029169332 @default.
- W2053552486 creator A5033112589 @default.
- W2053552486 date "2014-09-01" @default.
- W2053552486 modified "2023-10-07" @default.
- W2053552486 title "Review article: depression and the use of antidepressants in patients with chronic liver disease or liver transplantation" @default.
- W2053552486 cites W1479841946 @default.
- W2053552486 cites W1489608193 @default.
- W2053552486 cites W1517930663 @default.
- W2053552486 cites W1518177083 @default.
- W2053552486 cites W1522136588 @default.
- W2053552486 cites W1542582177 @default.
- W2053552486 cites W1578676387 @default.
- W2053552486 cites W1682825855 @default.
- W2053552486 cites W1700007903 @default.
- W2053552486 cites W189667296 @default.
- W2053552486 cites W1918348605 @default.
- W2053552486 cites W1965367995 @default.
- W2053552486 cites W1966509200 @default.
- W2053552486 cites W1970704812 @default.
- W2053552486 cites W1971866567 @default.
- W2053552486 cites W1972304663 @default.
- W2053552486 cites W1972531935 @default.
- W2053552486 cites W1974666586 @default.
- W2053552486 cites W1975379064 @default.
- W2053552486 cites W1975450391 @default.
- W2053552486 cites W1976897147 @default.
- W2053552486 cites W1978239985 @default.
- W2053552486 cites W1983369055 @default.
- W2053552486 cites W1983822054 @default.
- W2053552486 cites W1984338828 @default.
- W2053552486 cites W1985261879 @default.
- W2053552486 cites W1985279329 @default.
- W2053552486 cites W1985469636 @default.
- W2053552486 cites W1986111677 @default.
- W2053552486 cites W1986237614 @default.
- W2053552486 cites W1986730863 @default.
- W2053552486 cites W1986862807 @default.
- W2053552486 cites W1988025623 @default.
- W2053552486 cites W1992692012 @default.
- W2053552486 cites W1998686416 @default.
- W2053552486 cites W2002632285 @default.
- W2053552486 cites W2002889253 @default.
- W2053552486 cites W2007449083 @default.
- W2053552486 cites W2008281855 @default.
- W2053552486 cites W2016029871 @default.
- W2053552486 cites W2018458873 @default.
- W2053552486 cites W2022289967 @default.
- W2053552486 cites W2025129891 @default.
- W2053552486 cites W2026352845 @default.
- W2053552486 cites W2031733304 @default.
- W2053552486 cites W2036955341 @default.
- W2053552486 cites W2038382356 @default.
- W2053552486 cites W2038387606 @default.
- W2053552486 cites W2039697590 @default.
- W2053552486 cites W2040843575 @default.
- W2053552486 cites W2042012325 @default.
- W2053552486 cites W2042191290 @default.
- W2053552486 cites W2042720628 @default.
- W2053552486 cites W2043538665 @default.
- W2053552486 cites W2046571381 @default.
- W2053552486 cites W2047961388 @default.
- W2053552486 cites W2051633925 @default.
- W2053552486 cites W2055725287 @default.
- W2053552486 cites W2058051739 @default.
- W2053552486 cites W2064278664 @default.
- W2053552486 cites W2065250812 @default.
- W2053552486 cites W2065840120 @default.
- W2053552486 cites W2066439530 @default.
- W2053552486 cites W2066487799 @default.
- W2053552486 cites W2067855438 @default.
- W2053552486 cites W2068894011 @default.
- W2053552486 cites W2070097736 @default.
- W2053552486 cites W2070305087 @default.
- W2053552486 cites W2072740626 @default.
- W2053552486 cites W2075103004 @default.
- W2053552486 cites W2079520331 @default.
- W2053552486 cites W2080192957 @default.
- W2053552486 cites W2080522294 @default.
- W2053552486 cites W2081403823 @default.
- W2053552486 cites W2083615603 @default.
- W2053552486 cites W2086673416 @default.
- W2053552486 cites W2092482063 @default.
- W2053552486 cites W2093374310 @default.
- W2053552486 cites W2093578953 @default.
- W2053552486 cites W2095509520 @default.
- W2053552486 cites W2097010889 @default.
- W2053552486 cites W2097617011 @default.
- W2053552486 cites W2099831657 @default.
- W2053552486 cites W2107044757 @default.
- W2053552486 cites W2108344016 @default.
- W2053552486 cites W2115000098 @default.
- W2053552486 cites W2122895462 @default.
- W2053552486 cites W2123277906 @default.
- W2053552486 cites W2127129107 @default.