Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053559208> ?p ?o ?g. }
- W2053559208 endingPage "88" @default.
- W2053559208 startingPage "75" @default.
- W2053559208 abstract "Abstract The mucoadhesive properties of chitosan and chitosan microspheres were evaluated by studying the interaction between mucin and chitosan in aqueous solution by turbidimetric measurements and the measurement of mucin adsorbed on the microspheres. A strong interaction between chitosan microspheres and mucin was detected. Adsorption studies were carried out for the adsorption of mucin to chitosan microspheres with different crosslinking levels. The adsorption of type III mucin (1% sialic acid content), to chitosan microspheres followed Freundlich or Langmuir adsorption isotherms. When the contents of sialic acid was increased (i.e. type I-S mucin, 12% sialic acid content), the adsorption type followed more closely an electrostatic attraction type of isotherm. The heat of the adsorption was found to be 13–23 kJ/mol. A salt-bridge effect has been proposed for the interaction of the positively charged mucoadhesive chitosan microspheres with the negatively charged mucus glycoprotein. The extent of mucus adsorption was proportional to the absolute values of the positive zeta potential of chitosan microspheres and negative `zeta potential' of mucus glycoprotein. Factors leading to a reduction or a reversal of these absolute values (e.g. different crosslinking levels of chitosan microspheres, different types of mucin, different pH, or ionic strength of the medium used) led to a reduction in the amount adsorbed. The extent of this reduction depended upon the decreasing extent of the repective zeta potentials. Biological studies showed that chitosan microspheres were retained by a biological tissue; rat small intestine." @default.
- W2053559208 created "2016-06-24" @default.
- W2053559208 creator A5057809897 @default.
- W2053559208 creator A5062009761 @default.
- W2053559208 creator A5083779664 @default.
- W2053559208 date "1998-05-01" @default.
- W2053559208 modified "2023-10-18" @default.
- W2053559208 title "In vitro evaluation of the mucoadhesive properties of chitosan microspheres" @default.
- W2053559208 cites W113371168 @default.
- W2053559208 cites W1485145206 @default.
- W2053559208 cites W1506242946 @default.
- W2053559208 cites W1548751297 @default.
- W2053559208 cites W1549978738 @default.
- W2053559208 cites W1775112648 @default.
- W2053559208 cites W1980296334 @default.
- W2053559208 cites W1981313043 @default.
- W2053559208 cites W1987439231 @default.
- W2053559208 cites W1988373919 @default.
- W2053559208 cites W1993722110 @default.
- W2053559208 cites W2000730752 @default.
- W2053559208 cites W2004539400 @default.
- W2053559208 cites W2007236241 @default.
- W2053559208 cites W2021670659 @default.
- W2053559208 cites W2028311524 @default.
- W2053559208 cites W2034266006 @default.
- W2053559208 cites W2053125096 @default.
- W2053559208 cites W2055482526 @default.
- W2053559208 cites W2058213737 @default.
- W2053559208 cites W2058593524 @default.
- W2053559208 cites W2060397516 @default.
- W2053559208 cites W2072325032 @default.
- W2053559208 cites W2072515072 @default.
- W2053559208 cites W2083857325 @default.
- W2053559208 cites W2085373061 @default.
- W2053559208 cites W2087124372 @default.
- W2053559208 cites W2101086611 @default.
- W2053559208 cites W2125918187 @default.
- W2053559208 cites W2152593777 @default.
- W2053559208 cites W2321053095 @default.
- W2053559208 cites W2328158520 @default.
- W2053559208 cites W2333042007 @default.
- W2053559208 cites W2489754848 @default.
- W2053559208 cites W353722211 @default.
- W2053559208 cites W88725230 @default.
- W2053559208 doi "https://doi.org/10.1016/s0378-5173(98)00027-1" @default.
- W2053559208 hasPublicationYear "1998" @default.
- W2053559208 type Work @default.
- W2053559208 sameAs 2053559208 @default.
- W2053559208 citedByCount "579" @default.
- W2053559208 countsByYear W20535592082012 @default.
- W2053559208 countsByYear W20535592082013 @default.
- W2053559208 countsByYear W20535592082014 @default.
- W2053559208 countsByYear W20535592082015 @default.
- W2053559208 countsByYear W20535592082016 @default.
- W2053559208 countsByYear W20535592082017 @default.
- W2053559208 countsByYear W20535592082018 @default.
- W2053559208 countsByYear W20535592082019 @default.
- W2053559208 countsByYear W20535592082020 @default.
- W2053559208 countsByYear W20535592082021 @default.
- W2053559208 countsByYear W20535592082022 @default.
- W2053559208 countsByYear W20535592082023 @default.
- W2053559208 crossrefType "journal-article" @default.
- W2053559208 hasAuthorship W2053559208A5057809897 @default.
- W2053559208 hasAuthorship W2053559208A5062009761 @default.
- W2053559208 hasAuthorship W2053559208A5083779664 @default.
- W2053559208 hasConcept C127413603 @default.
- W2053559208 hasConcept C185592680 @default.
- W2053559208 hasConcept C189942447 @default.
- W2053559208 hasConcept C202751555 @default.
- W2053559208 hasConcept C2779732960 @default.
- W2053559208 hasConcept C2984430287 @default.
- W2053559208 hasConcept C42360764 @default.
- W2053559208 hasConcept C43617362 @default.
- W2053559208 hasConcept C55493867 @default.
- W2053559208 hasConcept C77281830 @default.
- W2053559208 hasConceptScore W2053559208C127413603 @default.
- W2053559208 hasConceptScore W2053559208C185592680 @default.
- W2053559208 hasConceptScore W2053559208C189942447 @default.
- W2053559208 hasConceptScore W2053559208C202751555 @default.
- W2053559208 hasConceptScore W2053559208C2779732960 @default.
- W2053559208 hasConceptScore W2053559208C2984430287 @default.
- W2053559208 hasConceptScore W2053559208C42360764 @default.
- W2053559208 hasConceptScore W2053559208C43617362 @default.
- W2053559208 hasConceptScore W2053559208C55493867 @default.
- W2053559208 hasConceptScore W2053559208C77281830 @default.
- W2053559208 hasIssue "1" @default.
- W2053559208 hasLocation W20535592081 @default.
- W2053559208 hasOpenAccess W2053559208 @default.
- W2053559208 hasPrimaryLocation W20535592081 @default.
- W2053559208 hasRelatedWork W2060445899 @default.
- W2053559208 hasRelatedWork W2060802043 @default.
- W2053559208 hasRelatedWork W2084481163 @default.
- W2053559208 hasRelatedWork W2112460934 @default.
- W2053559208 hasRelatedWork W2355973237 @default.
- W2053559208 hasRelatedWork W2386000149 @default.
- W2053559208 hasRelatedWork W3047328633 @default.
- W2053559208 hasRelatedWork W4232412908 @default.
- W2053559208 hasRelatedWork W2486951080 @default.