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- W2053568311 abstract "Severed halves of medial giant axons (MGAs) and lateral giant axons (LGAs) in earthworms survive and are functionally reconnected as early as the first postoperative week. During the first 150 postoperative days, there is an increase in conduction velocity of action potentials and strength of electrotonic coupling between the severed axonal stumps across the lesion site. Electrophysiological analyses suggest that this functional reconnection occurs by transmission of action potentials through the lesion site by active propagation along neurites which make electrotonic connections rather than chemical synapses. The regenerated connections restore the original connectivity pattern for conduction of action potentials or spread of electrotonic potentials; i.e., MGA stumps reconnect with MGA stumps, and LGA stumps with LGA stumps. These and other data suggest that the mechanisms responsible for establishing appropriate functional reconnection of severed earthworm giant axons requires cell-specific matching of axons and neurites, rather than a competition between appropriate and inappropriate functional connections." @default.
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- W2053568311 date "1992-09-01" @default.
- W2053568311 modified "2023-09-25" @default.
- W2053568311 title "Axonal conduction and electrical coupling in regenerating earthworm giant axons" @default.
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- W2053568311 doi "https://doi.org/10.1016/0014-4886(92)90139-h" @default.
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