Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053572659> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2053572659 endingPage "162" @default.
- W2053572659 startingPage "162" @default.
- W2053572659 abstract "Cytosolic Ca2+ concentration of rat ventricular cells was measured under varying experimental conditions by using a fluorescent Ca2+ indicator, Fura-2. Resting [Ca2+]i of rat myocyte was 150 +/- 30 nM (n = 39), and this value was compatible with others. The Perfusion of cardioplegic solution significantly increased [Ca2+]i, and this effect was further augmented by hypothermia (p < 0.05). Application of nifedipine (5 x 10(-7) M) to the perfusate or pretreatment of caffeine (10 mM) had no apparent effect on this cardioplegia-induced [Ca2+]i change. But Ni2+ (5 mM), an antagonist of Na+/Ca2+ exchange mechanism, prevented the [Ca2+]i change during cardioplegia (p < 0.05). Magnitude of cardioplegia-induced [Ca2+]i increase was also dependent on the Ca2+ concentration of cardioplegic solution. These results suggest that Na+/Ca2+ exchange may play an important role in cardioplegia-induced [Ca2+]i change. To rule out the possibility whether the protective effect of hypothermic cardioplegia is due to the preservation of high-energy phosphate store or decreasing the transmembrane ionic fluxes by phase transition, we exhausted a energy store of cardiac cell by application of 2,4 dinitrophenol to the bath and measured its effect on [Ca2+]i change during cardioplegia. Hypothermic cardioplegia delayed the onset of [Ca2+]i increase and decreased its amplitude compared to those of normothermic cardioplegia. From the above results, hypothermic cardioplegia may protect the cardiac cells from ischemic insult by preserving a high-energy phosphate store. Application of Ni2+ to the cardioplegic solution or reduction of external Ca2+ concentration also had some protective effect, since it prevented [Ca2+]i increase during cardioplegia." @default.
- W2053572659 created "2016-06-24" @default.
- W2053572659 creator A5007867229 @default.
- W2053572659 creator A5009677168 @default.
- W2053572659 creator A5028530220 @default.
- W2053572659 creator A5047843177 @default.
- W2053572659 date "1994-01-01" @default.
- W2053572659 modified "2023-09-23" @default.
- W2053572659 title "Effect of hypothermic cardioplegia on cardiac protection -I. Effect of hypothermic cardioplegia on the cytosolic Ca2+concentration in rat ventricular myocytes-" @default.
- W2053572659 doi "https://doi.org/10.3349/ymj.1994.35.2.162" @default.
- W2053572659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8091793" @default.
- W2053572659 hasPublicationYear "1994" @default.
- W2053572659 type Work @default.
- W2053572659 sameAs 2053572659 @default.
- W2053572659 citedByCount "6" @default.
- W2053572659 countsByYear W20535726592012 @default.
- W2053572659 crossrefType "journal-article" @default.
- W2053572659 hasAuthorship W2053572659A5007867229 @default.
- W2053572659 hasAuthorship W2053572659A5009677168 @default.
- W2053572659 hasAuthorship W2053572659A5028530220 @default.
- W2053572659 hasAuthorship W2053572659A5047843177 @default.
- W2053572659 hasBestOaLocation W20535726591 @default.
- W2053572659 hasConcept C126322002 @default.
- W2053572659 hasConcept C146957229 @default.
- W2053572659 hasConcept C164705383 @default.
- W2053572659 hasConcept C181199279 @default.
- W2053572659 hasConcept C185592680 @default.
- W2053572659 hasConcept C207200792 @default.
- W2053572659 hasConcept C2777390192 @default.
- W2053572659 hasConcept C2778500429 @default.
- W2053572659 hasConcept C2779066535 @default.
- W2053572659 hasConcept C42219234 @default.
- W2053572659 hasConcept C519063684 @default.
- W2053572659 hasConcept C55493867 @default.
- W2053572659 hasConcept C71924100 @default.
- W2053572659 hasConcept C98539663 @default.
- W2053572659 hasConceptScore W2053572659C126322002 @default.
- W2053572659 hasConceptScore W2053572659C146957229 @default.
- W2053572659 hasConceptScore W2053572659C164705383 @default.
- W2053572659 hasConceptScore W2053572659C181199279 @default.
- W2053572659 hasConceptScore W2053572659C185592680 @default.
- W2053572659 hasConceptScore W2053572659C207200792 @default.
- W2053572659 hasConceptScore W2053572659C2777390192 @default.
- W2053572659 hasConceptScore W2053572659C2778500429 @default.
- W2053572659 hasConceptScore W2053572659C2779066535 @default.
- W2053572659 hasConceptScore W2053572659C42219234 @default.
- W2053572659 hasConceptScore W2053572659C519063684 @default.
- W2053572659 hasConceptScore W2053572659C55493867 @default.
- W2053572659 hasConceptScore W2053572659C71924100 @default.
- W2053572659 hasConceptScore W2053572659C98539663 @default.
- W2053572659 hasIssue "2" @default.
- W2053572659 hasLocation W20535726591 @default.
- W2053572659 hasLocation W20535726592 @default.
- W2053572659 hasOpenAccess W2053572659 @default.
- W2053572659 hasPrimaryLocation W20535726591 @default.
- W2053572659 hasRelatedWork W1531601525 @default.
- W2053572659 hasRelatedWork W1990451572 @default.
- W2053572659 hasRelatedWork W1998919732 @default.
- W2053572659 hasRelatedWork W2029852425 @default.
- W2053572659 hasRelatedWork W2062920450 @default.
- W2053572659 hasRelatedWork W2071225392 @default.
- W2053572659 hasRelatedWork W2366279150 @default.
- W2053572659 hasRelatedWork W2948807893 @default.
- W2053572659 hasRelatedWork W2952709229 @default.
- W2053572659 hasRelatedWork W2778153218 @default.
- W2053572659 hasVolume "35" @default.
- W2053572659 isParatext "false" @default.
- W2053572659 isRetracted "false" @default.
- W2053572659 magId "2053572659" @default.
- W2053572659 workType "article" @default.