FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053584356> ?p ?o ?g. }

• W2053584356 endingPage "12" @default.
• W2053584356 startingPage "2" @default.
• W2053584356 abstract "To compare the efficacy and tolerability of felodipine extended release (ER) 2.5 mg (F2.5) and 5 mg (F5) once daily with nifedipine Retard 10 mg (N20) and 20 mg (N40) twice daily as additional therapy in patients who remained hypertensive despite treatment with an ACE-inhibitor, beta-blocker or diuretic.In a multicentre, double-blind parallel study, 61 men and 54 women, aged 35-75, with a supine diastolic blood pressure between 95 and 115 mmHg were randomised to treatment with F2.5, F5, N20 or N40 for 8 weeks, with optional doubling of the dose after 4 weeks. Blood pressure was measured at the office after 0, 4 and 8 weeks and by 24-h ambulatory monitoring (ABPM) after 0 and 4 weeks. Spontaneously reported adverse events and a subjective symptom assessment questionnaire were used for side-effect profiling.Mean office systolic/diastolic blood pressure was clinically relevantly reduced in all treatment groups after 4 weeks by 8/7, 12/9, 11/9 and 18/11 mmHg for F2.5, F5, N20 and N40, respectively, and after 8 weeks (F2.5-5: 17/11 mmHg: F5-10: 18/14 mmHg; N20-40: 19/14 mmHg; N40-80: 25/14 mmHg) with no statistically significant differences between these groups. The lowest dose of felodipine (F2.5) was the least effective. After 4 weeks the ABPM showed consistent 24-h reductions in blood pressure (4/2; 8/5; 7/5; 10/6 mmHg, respectively) over 24 h for the felodipine ER 5 mg group only and for both nifedipine groups. No statistically significant difference between these groups was found. An office responder does not appear to be identical to an ambulatory one and vice versa. The adverse events, mostly oedema, flushing and headache, were dose-related.Both felodipine ER and nifedipine Retard are effective add-on' drugs in patients with monotherapy-resistant hypertension. The blood-pressure-lowering effect is dose-dependent and tolerability is inversely related to efficacy. The results emphasize the benefits of combining two agents with low doses." @default.
• W2053584356 created "2016-06-24" @default.
• W2053584356 creator A5009973327 @default.
• W2053584356 creator A5027745539 @default.
• W2053584356 creator A5033039884 @default.
• W2053584356 creator A5035369834 @default.
• W2053584356 creator A5056415259 @default.
• W2053584356 creator A5068694021 @default.
• W2053584356 date "1997-01-01" @default.
• W2053584356 modified "2023-09-23" @default.
• W2053584356 title "Calcium antagonists, a useful additional therapy in treatment resistant hypertension: Comparison of felodipine ER and nifedipine Retard by 24-h ambulatory blood pressure monitoring" @default.
• W2053584356 cites W1980587390 @default.
• W2053584356 cites W1982162449 @default.
• W2053584356 cites W1983764386 @default.
• W2053584356 cites W1984399748 @default.
• W2053584356 cites W1987547653 @default.
• W2053584356 cites W2007918326 @default.
• W2053584356 cites W2041462266 @default.
• W2053584356 cites W2044950360 @default.
• W2053584356 cites W2059124189 @default.
• W2053584356 cites W2065616454 @default.
• W2053584356 cites W2070070759 @default.
• W2053584356 cites W2098744676 @default.
• W2053584356 cites W2123096968 @default.
• W2053584356 cites W2126839153 @default.
• W2053584356 cites W2156003480 @default.
• W2053584356 cites W2324403952 @default.
• W2053584356 cites W2407419780 @default.
• W2053584356 cites W2413177606 @default.
• W2053584356 cites W3144027583 @default.
• W2053584356 cites W35510491 @default.
• W2053584356 doi "https://doi.org/10.1016/s0300-2977(96)00077-0" @default.
• W2053584356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9038037" @default.
• W2053584356 hasPublicationYear "1997" @default.
• W2053584356 type Work @default.
• W2053584356 sameAs 2053584356 @default.
• W2053584356 citedByCount "4" @default.
• W2053584356 crossrefType "journal-article" @default.
• W2053584356 hasAuthorship W2053584356A5009973327 @default.
• W2053584356 hasAuthorship W2053584356A5027745539 @default.
• W2053584356 hasAuthorship W2053584356A5033039884 @default.
• W2053584356 hasAuthorship W2053584356A5035369834 @default.
• W2053584356 hasAuthorship W2053584356A5056415259 @default.
• W2053584356 hasAuthorship W2053584356A5068694021 @default.
• W2053584356 hasConcept C125567185 @default.
• W2053584356 hasConcept C126322002 @default.
• W2053584356 hasConcept C126894567 @default.
• W2053584356 hasConcept C149323552 @default.
• W2053584356 hasConcept C164705383 @default.
• W2053584356 hasConcept C197934379 @default.
• W2053584356 hasConcept C2777097880 @default.
• W2053584356 hasConcept C2778375690 @default.
• W2053584356 hasConcept C2779066535 @default.
• W2053584356 hasConcept C2779918671 @default.
• W2053584356 hasConcept C2780361556 @default.
• W2053584356 hasConcept C2780648877 @default.
• W2053584356 hasConcept C35785553 @default.
• W2053584356 hasConcept C42219234 @default.
• W2053584356 hasConcept C519063684 @default.
• W2053584356 hasConcept C57900726 @default.
• W2053584356 hasConcept C71924100 @default.
• W2053584356 hasConcept C84393581 @default.
• W2053584356 hasConceptScore W2053584356C125567185 @default.
• W2053584356 hasConceptScore W2053584356C126322002 @default.
• W2053584356 hasConceptScore W2053584356C126894567 @default.
• W2053584356 hasConceptScore W2053584356C149323552 @default.
• W2053584356 hasConceptScore W2053584356C164705383 @default.
• W2053584356 hasConceptScore W2053584356C197934379 @default.
• W2053584356 hasConceptScore W2053584356C2777097880 @default.
• W2053584356 hasConceptScore W2053584356C2778375690 @default.
• W2053584356 hasConceptScore W2053584356C2779066535 @default.
• W2053584356 hasConceptScore W2053584356C2779918671 @default.
• W2053584356 hasConceptScore W2053584356C2780361556 @default.
• W2053584356 hasConceptScore W2053584356C2780648877 @default.
• W2053584356 hasConceptScore W2053584356C35785553 @default.
• W2053584356 hasConceptScore W2053584356C42219234 @default.
• W2053584356 hasConceptScore W2053584356C519063684 @default.
• W2053584356 hasConceptScore W2053584356C57900726 @default.
• W2053584356 hasConceptScore W2053584356C71924100 @default.
• W2053584356 hasConceptScore W2053584356C84393581 @default.
• W2053584356 hasIssue "1" @default.
• W2053584356 hasLocation W20535843561 @default.
• W2053584356 hasLocation W20535843562 @default.
• W2053584356 hasOpenAccess W2053584356 @default.
• W2053584356 hasPrimaryLocation W20535843561 @default.
• W2053584356 hasRelatedWork W131083658 @default.
• W2053584356 hasRelatedWork W2053584356 @default.
• W2053584356 hasRelatedWork W2075223671 @default.
• W2053584356 hasRelatedWork W2103896127 @default.
• W2053584356 hasRelatedWork W2351940717 @default.
• W2053584356 hasRelatedWork W2376996501 @default.
• W2053584356 hasRelatedWork W2379909583 @default.
• W2053584356 hasRelatedWork W2390764089 @default.
• W2053584356 hasRelatedWork W2391671546 @default.
• W2053584356 hasRelatedWork W2414038239 @default.
• W2053584356 hasVolume "50" @default.
• W2053584356 isParatext "false" @default.
• W2053584356 isRetracted "false" @default.

• next