FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053589174> ?p ?o ?g. }

• W2053589174 endingPage "426" @default.
• W2053589174 startingPage "413" @default.
• W2053589174 abstract "JAK/STAT signaling is localized to the wing hinge, but its function there is not known. Here we show that the Drosophila STAT Stat92E is downstream of Homothorax and is required for hinge development by cell-autonomously regulating hinge-specific factors. Within the hinge, Stat92E activity becomes restricted to gap domain cells that lack Nubbin and Teashirt. While gap domain cells lacking Stat92E have significantly reduced proliferation, increased JAK/STAT signaling there does not expand this domain. Thus, this pathway is necessary but not sufficient for gap domain growth. We show that reduced Wingless (Wg) signaling dominantly inhibits Stat92E activity in the hinge. However, ectopic JAK/STAT signaling does not perturb Wg expression in the hinge. We report negative interactions between Stat92E and the notum factor Araucan, resulting in restriction of JAK/STAT signaling from the notum. In addition, we find that the distal factor Nub represses the ligand unpaired as well as Stat92E activity. These data suggest that distal expansion of JAK/STAT signaling is deleterious to wing blade development. Indeed, mis-expression of Unpaired within the presumptive wing blade causes small, stunted adult wings. We conclude that JAK/STAT signaling is critical for hinge fate specification and growth of the gap domain and that its restriction to the hinge is required for proper wing development." @default.
• W2053589174 created "2016-06-24" @default.
• W2053589174 creator A5019362320 @default.
• W2053589174 creator A5024697903 @default.
• W2053589174 creator A5029351598 @default.
• W2053589174 creator A5056119819 @default.
• W2053589174 creator A5063004441 @default.
• W2053589174 creator A5063635980 @default.
• W2053589174 date "2013-10-01" @default.
• W2053589174 modified "2023-10-10" @default.
• W2053589174 title "JAK/STAT signaling is required for hinge growth and patterning in the Drosophila wing disc" @default.
• W2053589174 cites W1825806483 @default.
• W2053589174 cites W1893695128 @default.
• W2053589174 cites W1927821967 @default.
• W2053589174 cites W1969032952 @default.
• W2053589174 cites W1970084686 @default.
• W2053589174 cites W1977609086 @default.
• W2053589174 cites W1981144245 @default.
• W2053589174 cites W1993027373 @default.
• W2053589174 cites W1996697923 @default.
• W2053589174 cites W1997332250 @default.
• W2053589174 cites W1998020029 @default.
• W2053589174 cites W1998148517 @default.
• W2053589174 cites W2003116605 @default.
• W2053589174 cites W2008388656 @default.
• W2053589174 cites W2018761778 @default.
• W2053589174 cites W2026377725 @default.
• W2053589174 cites W2027298582 @default.
• W2053589174 cites W2030266533 @default.
• W2053589174 cites W2033482280 @default.
• W2053589174 cites W2035000134 @default.
• W2053589174 cites W2048896882 @default.
• W2053589174 cites W2051548576 @default.
• W2053589174 cites W2059276027 @default.
• W2053589174 cites W2063832919 @default.
• W2053589174 cites W2066783571 @default.
• W2053589174 cites W2080820187 @default.
• W2053589174 cites W2081569487 @default.
• W2053589174 cites W2088288898 @default.
• W2053589174 cites W2090095287 @default.
• W2053589174 cites W2093972267 @default.
• W2053589174 cites W2094356495 @default.
• W2053589174 cites W2096214882 @default.
• W2053589174 cites W2100070586 @default.
• W2053589174 cites W2103886590 @default.
• W2053589174 cites W2106006661 @default.
• W2053589174 cites W2106015429 @default.
• W2053589174 cites W2108545226 @default.
• W2053589174 cites W2108701179 @default.
• W2053589174 cites W2110643873 @default.
• W2053589174 cites W2126362074 @default.
• W2053589174 cites W2130563948 @default.
• W2053589174 cites W2133916746 @default.
• W2053589174 cites W2147697223 @default.
• W2053589174 cites W2151006454 @default.
• W2053589174 cites W2152900108 @default.
• W2053589174 cites W2155327121 @default.
• W2053589174 cites W2159707687 @default.
• W2053589174 cites W2159935247 @default.
• W2053589174 cites W2160064773 @default.
• W2053589174 cites W2161427546 @default.
• W2053589174 cites W2169536561 @default.
• W2053589174 cites W2172033040 @default.
• W2053589174 cites W2184390227 @default.
• W2053589174 cites W2248809989 @default.
• W2053589174 cites W321588607 @default.
• W2053589174 doi "https://doi.org/10.1016/j.ydbio.2013.08.016" @default.
• W2053589174 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3795806" @default.
• W2053589174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23978534" @default.
• W2053589174 hasPublicationYear "2013" @default.
• W2053589174 type Work @default.
• W2053589174 sameAs 2053589174 @default.
• W2053589174 citedByCount "40" @default.
• W2053589174 countsByYear W20535891742014 @default.
• W2053589174 countsByYear W20535891742015 @default.
• W2053589174 countsByYear W20535891742016 @default.
• W2053589174 countsByYear W20535891742017 @default.
• W2053589174 countsByYear W20535891742018 @default.
• W2053589174 countsByYear W20535891742019 @default.
• W2053589174 countsByYear W20535891742020 @default.
• W2053589174 countsByYear W20535891742021 @default.
• W2053589174 countsByYear W20535891742022 @default.
• W2053589174 countsByYear W20535891742023 @default.
• W2053589174 crossrefType "journal-article" @default.
• W2053589174 hasAuthorship W2053589174A5019362320 @default.
• W2053589174 hasAuthorship W2053589174A5024697903 @default.
• W2053589174 hasAuthorship W2053589174A5029351598 @default.
• W2053589174 hasAuthorship W2053589174A5056119819 @default.
• W2053589174 hasAuthorship W2053589174A5063004441 @default.
• W2053589174 hasAuthorship W2053589174A5063635980 @default.
• W2053589174 hasBestOaLocation W20535891741 @default.
• W2053589174 hasConcept C127413603 @default.
• W2053589174 hasConcept C146978453 @default.
• W2053589174 hasConcept C157333092 @default.
• W2053589174 hasConcept C2778277574 @default.
• W2053589174 hasConcept C2778923194 @default.
• W2053589174 hasConcept C42362537 @default.
• W2053589174 hasConcept C44000306 @default.

• next