FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053589941> ?p ?o ?g. }

• W2053589941 endingPage "e529" @default.
• W2053589941 startingPage "e529" @default.
• W2053589941 abstract "Human lymphatic filariasis is a mosquito-vectored disease caused by the nematode parasites Wuchereria bancrofti, Brugia malayi and Brugia timori. These are relatively large roundworms that can cause considerable damage in compatible mosquito vectors. In order to assess how mosquitoes respond to infection in compatible mosquito-filarial worm associations, microarray analysis was used to evaluate transcriptome changes in Aedes aegypti at various times during B. malayi development. Changes in transcript abundance in response to the different stages of B. malayi infection were diverse. At the early stages of midgut and thoracic muscle cell penetration, a greater number of genes were repressed compared to those that were induced (20 vs. 8). The non-feeding, intracellular first-stage larvae elicited few differences, with 4 transcripts showing an increased and 9 a decreased abundance relative to controls. Several cecropin transcripts increased in abundance after parasites molted to second-stage larvae. However, the greatest number of transcripts changed in abundance after larvae molted to third-stage larvae and migrated to the head and proboscis (120 induced, 38 repressed), including a large number of putative, immunity-related genes (approximately 13% of genes with predicted functions). To test whether the innate immune system of mosquitoes was capable of modulating permissiveness to the parasite, we activated the Toll and Imd pathway controlled rel family transcription factors Rel1 and Rel2 (by RNA interference knockdown of the pathway's negative regulators Cactus and Caspar) during the early stages of infection with B. malayi. The activation of either of these immune signaling pathways, or knockdown of the Toll pathway, did not affect B. malayi in Ae. aegypti. The possibility of LF parasites evading mosquito immune responses during successful development is discussed." @default.
• W2053589941 created "2016-06-24" @default.
• W2053589941 creator A5012534121 @default.
• W2053589941 creator A5041160284 @default.
• W2053589941 creator A5068940286 @default.
• W2053589941 creator A5070697792 @default.
• W2053589941 creator A5075932475 @default.
• W2053589941 creator A5077779717 @default.
• W2053589941 creator A5087537891 @default.
• W2053589941 date "2009-10-13" @default.
• W2053589941 modified "2023-10-14" @default.
• W2053589941 title "Mosquito Infection Responses to Developing Filarial Worms" @default.
• W2053589941 cites W1495066004 @default.
• W2053589941 cites W1518457092 @default.
• W2053589941 cites W1547074150 @default.
• W2053589941 cites W1891228765 @default.
• W2053589941 cites W1979321978 @default.
• W2053589941 cites W1981389417 @default.
• W2053589941 cites W1994181567 @default.
• W2053589941 cites W2001419566 @default.
• W2053589941 cites W2007749358 @default.
• W2053589941 cites W2009693677 @default.
• W2053589941 cites W2010072816 @default.
• W2053589941 cites W2011247119 @default.
• W2053589941 cites W2015269515 @default.
• W2053589941 cites W2023739559 @default.
• W2053589941 cites W2030551855 @default.
• W2053589941 cites W2033955011 @default.
• W2053589941 cites W2041259751 @default.
• W2053589941 cites W2043149053 @default.
• W2053589941 cites W2046934303 @default.
• W2053589941 cites W2048616259 @default.
• W2053589941 cites W2049507260 @default.
• W2053589941 cites W2059471379 @default.
• W2053589941 cites W2060391460 @default.
• W2053589941 cites W2061054199 @default.
• W2053589941 cites W2062984580 @default.
• W2053589941 cites W2083085665 @default.
• W2053589941 cites W2091036933 @default.
• W2053589941 cites W2101396620 @default.
• W2053589941 cites W2122000315 @default.
• W2053589941 cites W2140113867 @default.
• W2053589941 cites W2158091936 @default.
• W2053589941 cites W2161733022 @default.
• W2053589941 cites W2164310330 @default.
• W2053589941 cites W2166067725 @default.
• W2053589941 cites W2170932122 @default.
• W2053589941 cites W2171158206 @default.
• W2053589941 cites W2171760913 @default.
• W2053589941 cites W2194050578 @default.
• W2053589941 cites W2312537902 @default.
• W2053589941 cites W2318362015 @default.
• W2053589941 cites W2320367390 @default.
• W2053589941 cites W2343955585 @default.
• W2053589941 cites W2528023582 @default.
• W2053589941 cites W3067505 @default.
• W2053589941 cites W45534775 @default.
• W2053589941 doi "https://doi.org/10.1371/journal.pntd.0000529" @default.
• W2053589941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2752998" @default.
• W2053589941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19823571" @default.
• W2053589941 hasPublicationYear "2009" @default.
• W2053589941 type Work @default.
• W2053589941 sameAs 2053589941 @default.
• W2053589941 citedByCount "66" @default.
• W2053589941 countsByYear W20535899412012 @default.
• W2053589941 countsByYear W20535899412013 @default.
• W2053589941 countsByYear W20535899412014 @default.
• W2053589941 countsByYear W20535899412015 @default.
• W2053589941 countsByYear W20535899412016 @default.
• W2053589941 countsByYear W20535899412017 @default.
• W2053589941 countsByYear W20535899412018 @default.
• W2053589941 countsByYear W20535899412019 @default.
• W2053589941 countsByYear W20535899412020 @default.
• W2053589941 countsByYear W20535899412021 @default.
• W2053589941 countsByYear W20535899412022 @default.
• W2053589941 countsByYear W20535899412023 @default.
• W2053589941 crossrefType "journal-article" @default.
• W2053589941 hasAuthorship W2053589941A5012534121 @default.
• W2053589941 hasAuthorship W2053589941A5041160284 @default.
• W2053589941 hasAuthorship W2053589941A5068940286 @default.
• W2053589941 hasAuthorship W2053589941A5070697792 @default.
• W2053589941 hasAuthorship W2053589941A5075932475 @default.
• W2053589941 hasAuthorship W2053589941A5077779717 @default.
• W2053589941 hasAuthorship W2053589941A5087537891 @default.
• W2053589941 hasBestOaLocation W20535899411 @default.
• W2053589941 hasConcept C104317684 @default.
• W2053589941 hasConcept C159047783 @default.
• W2053589941 hasConcept C165901193 @default.
• W2053589941 hasConcept C173396325 @default.
• W2053589941 hasConcept C173758957 @default.
• W2053589941 hasConcept C18903297 @default.
• W2053589941 hasConcept C203014093 @default.
• W2053589941 hasConcept C2775848585 @default.
• W2053589941 hasConcept C2776158911 @default.
• W2053589941 hasConcept C2776802408 @default.
• W2053589941 hasConcept C2777629521 @default.
• W2053589941 hasConcept C2777775583 @default.
• W2053589941 hasConcept C2778048844 @default.

• next