Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053610744> ?p ?o ?g. }
- W2053610744 endingPage "1214" @default.
- W2053610744 startingPage "1201" @default.
- W2053610744 abstract "Dynamic contrast-enhanced magnetic resonance imaging (MRI) is widely used for measuring perfusion and blood volume, especially cerebral blood volume (CBV). In case of blood-brain barrier (BBB) disruption, the conventional techniques only partially determine the pharmacokinetic parameters of contrast medium (CM) exchange between different compartments. Here a modified pharmacokinetic model is applied, which is based on the bidirectional CM exchange between blood and two interstitial compartments in terms of the fractional volumes of the compartments and the vessel permeabilities between them. The evaluation technique using this model allows one to quantify the fractional volumes of the different compartments (blood, cells, slowly and fast enhancing interstitium) as well as the vessel permeabilities and cerebral blood flow (CBF) with a single T1-weighted dynamic MRI measurement. The method has been successfully applied in 25 glioma patients for generating maps of all of these parameters. The fractional volume maps allow for the differentiation of glioma vascularization types. The maps show a good correlation with the histological grading of these tumors. Furthermore, regions with enhanced interstitial volumes are found in high-grade gliomas. Differences in permeability maps of Gd-DTPA apart from BBB disruption do not exist between different tissue types. CBF measured in high-grade glioma is less pronounced than it would be expected from their blood volume. Therefore pharmacokinetic imaging provides an additional tool for glioma characterization." @default.
- W2053610744 created "2016-06-24" @default.
- W2053610744 creator A5008969653 @default.
- W2053610744 creator A5071260490 @default.
- W2053610744 creator A5085312364 @default.
- W2053610744 date "2000-12-01" @default.
- W2053610744 modified "2023-10-11" @default.
- W2053610744 title "Pharmacokinetic analysis of glioma compartments with dynamic Gd-DTPA-enhanced magnetic resonance imaging" @default.
- W2053610744 cites W1480012785 @default.
- W2053610744 cites W1964615535 @default.
- W2053610744 cites W1973537869 @default.
- W2053610744 cites W1975996023 @default.
- W2053610744 cites W1976497875 @default.
- W2053610744 cites W1982328984 @default.
- W2053610744 cites W1987503485 @default.
- W2053610744 cites W1987857379 @default.
- W2053610744 cites W1990983926 @default.
- W2053610744 cites W1992333345 @default.
- W2053610744 cites W1997995944 @default.
- W2053610744 cites W2000584529 @default.
- W2053610744 cites W2008330732 @default.
- W2053610744 cites W2015660037 @default.
- W2053610744 cites W2016859917 @default.
- W2053610744 cites W2017210701 @default.
- W2053610744 cites W2022912277 @default.
- W2053610744 cites W2026901966 @default.
- W2053610744 cites W2036913456 @default.
- W2053610744 cites W2042098439 @default.
- W2053610744 cites W2043809826 @default.
- W2053610744 cites W2057720419 @default.
- W2053610744 cites W2057728297 @default.
- W2053610744 cites W2057816945 @default.
- W2053610744 cites W2065647919 @default.
- W2053610744 cites W2069132289 @default.
- W2053610744 cites W2074187663 @default.
- W2053610744 cites W2079256860 @default.
- W2053610744 cites W2087105630 @default.
- W2053610744 cites W2091776483 @default.
- W2053610744 cites W2108610949 @default.
- W2053610744 cites W2111147801 @default.
- W2053610744 cites W2111216878 @default.
- W2053610744 cites W2116385030 @default.
- W2053610744 cites W2120271827 @default.
- W2053610744 cites W2132072927 @default.
- W2053610744 cites W2133127239 @default.
- W2053610744 cites W2138001608 @default.
- W2053610744 cites W2140464965 @default.
- W2053610744 cites W2158072516 @default.
- W2053610744 cites W2161028152 @default.
- W2053610744 cites W2171263166 @default.
- W2053610744 cites W2322347825 @default.
- W2053610744 cites W2465745915 @default.
- W2053610744 cites W4247418439 @default.
- W2053610744 cites W4256300946 @default.
- W2053610744 doi "https://doi.org/10.1016/s0730-725x(00)00223-x" @default.
- W2053610744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11167040" @default.
- W2053610744 hasPublicationYear "2000" @default.
- W2053610744 type Work @default.
- W2053610744 sameAs 2053610744 @default.
- W2053610744 citedByCount "85" @default.
- W2053610744 countsByYear W20536107442012 @default.
- W2053610744 countsByYear W20536107442013 @default.
- W2053610744 countsByYear W20536107442014 @default.
- W2053610744 countsByYear W20536107442015 @default.
- W2053610744 countsByYear W20536107442016 @default.
- W2053610744 countsByYear W20536107442017 @default.
- W2053610744 countsByYear W20536107442018 @default.
- W2053610744 countsByYear W20536107442019 @default.
- W2053610744 countsByYear W20536107442022 @default.
- W2053610744 countsByYear W20536107442023 @default.
- W2053610744 crossrefType "journal-article" @default.
- W2053610744 hasAuthorship W2053610744A5008969653 @default.
- W2053610744 hasAuthorship W2053610744A5071260490 @default.
- W2053610744 hasAuthorship W2053610744A5085312364 @default.
- W2053610744 hasConcept C112705442 @default.
- W2053610744 hasConcept C113045295 @default.
- W2053610744 hasConcept C120882062 @default.
- W2053610744 hasConcept C121332964 @default.
- W2053610744 hasConcept C126322002 @default.
- W2053610744 hasConcept C126838900 @default.
- W2053610744 hasConcept C136229726 @default.
- W2053610744 hasConcept C142724271 @default.
- W2053610744 hasConcept C143409427 @default.
- W2053610744 hasConcept C146957229 @default.
- W2053610744 hasConcept C150489694 @default.
- W2053610744 hasConcept C157767197 @default.
- W2053610744 hasConcept C158846371 @default.
- W2053610744 hasConcept C164705383 @default.
- W2053610744 hasConcept C185592680 @default.
- W2053610744 hasConcept C18903297 @default.
- W2053610744 hasConcept C2777286243 @default.
- W2053610744 hasConcept C2778227246 @default.
- W2053610744 hasConcept C2781192897 @default.
- W2053610744 hasConcept C2982720008 @default.
- W2053610744 hasConcept C37557685 @default.
- W2053610744 hasConcept C41625074 @default.
- W2053610744 hasConcept C41727105 @default.
- W2053610744 hasConcept C46141821 @default.