Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053615511> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2053615511 endingPage "1021" @default.
- W2053615511 startingPage "1016" @default.
- W2053615511 abstract "We conducted a trial of a new less invasive, locoregional modality for lung cancer with pleural spread. This study was planned to investigate the feasibility, safety, and pharmacokinetics of pleural perfusion thermochemotherapy (PPTC) under video-assisted thoracoscopic surgery (VATS) and its modified method with a short perfusion time for preventing heat damage to the lung during the procedure.Seventeen patients, 59 to 79 years old, underwent surgical resection of the primary lesions and PPTC under VATS without thoracotomy. All had pleural spread with malignant effusion due to lung cancer proven before the treatment. PPTC consists of irrigating the pleural space with 42 degrees C saline solution containing cisplatin (200 mg/m(2)) using a devised circuit. The time for perfusion was two hours in 10 patients (group L), and one hour in 7 patients (group S).All patients successfully completed this treatment with acceptable toxicities. The pharmacokinetic analysis showed that high platinum levels for the regional pleural exposure, which was 20- to 40-fold greater than those for the plasma in both groups. These values were equivalent between the groups, although the levels for the plasma were higher in group L than in group S. Postoperative lung damage was seen in 4 patients with no serious conditions in group L, and none in group S. The median survival for the L and S groups was 17 and 19 months, respectively.This less invasive modality seems to offer a safe, feasible, and pharmacokinetically advantageous procedure to have excellent local control for lung cancer with pleural spread." @default.
- W2053615511 created "2016-06-24" @default.
- W2053615511 creator A5014936932 @default.
- W2053615511 creator A5025803389 @default.
- W2053615511 creator A5029835686 @default.
- W2053615511 creator A5033902748 @default.
- W2053615511 creator A5058261979 @default.
- W2053615511 creator A5081000734 @default.
- W2053615511 date "2004-03-01" @default.
- W2053615511 modified "2023-10-17" @default.
- W2053615511 title "Pleural perfusion thermo-chemotherapy under VATS: a new less invasive modality for advanced lung cancer with pleural spread" @default.
- W2053615511 cites W1601831174 @default.
- W2053615511 cites W1789570420 @default.
- W2053615511 cites W1877653742 @default.
- W2053615511 cites W1965363167 @default.
- W2053615511 cites W2000128860 @default.
- W2053615511 cites W2005019801 @default.
- W2053615511 cites W2021083786 @default.
- W2053615511 cites W2058949714 @default.
- W2053615511 cites W2088785174 @default.
- W2053615511 cites W2129132727 @default.
- W2053615511 cites W2407799133 @default.
- W2053615511 cites W2507995978 @default.
- W2053615511 cites W598338486 @default.
- W2053615511 cites W62756218 @default.
- W2053615511 doi "https://doi.org/10.1016/j.athoracsur.2003.08.012" @default.
- W2053615511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14992917" @default.
- W2053615511 hasPublicationYear "2004" @default.
- W2053615511 type Work @default.
- W2053615511 sameAs 2053615511 @default.
- W2053615511 citedByCount "10" @default.
- W2053615511 countsByYear W20536155112013 @default.
- W2053615511 countsByYear W20536155112015 @default.
- W2053615511 countsByYear W20536155112017 @default.
- W2053615511 crossrefType "journal-article" @default.
- W2053615511 hasAuthorship W2053615511A5014936932 @default.
- W2053615511 hasAuthorship W2053615511A5025803389 @default.
- W2053615511 hasAuthorship W2053615511A5029835686 @default.
- W2053615511 hasAuthorship W2053615511A5033902748 @default.
- W2053615511 hasAuthorship W2053615511A5058261979 @default.
- W2053615511 hasAuthorship W2053615511A5081000734 @default.
- W2053615511 hasBestOaLocation W20536155111 @default.
- W2053615511 hasConcept C112705442 @default.
- W2053615511 hasConcept C126322002 @default.
- W2053615511 hasConcept C126838900 @default.
- W2053615511 hasConcept C141071460 @default.
- W2053615511 hasConcept C146957229 @default.
- W2053615511 hasConcept C2776232967 @default.
- W2053615511 hasConcept C2776256026 @default.
- W2053615511 hasConcept C2776694085 @default.
- W2053615511 hasConcept C2777714996 @default.
- W2053615511 hasConcept C2778847313 @default.
- W2053615511 hasConcept C2779127879 @default.
- W2053615511 hasConcept C2779634585 @default.
- W2053615511 hasConcept C42219234 @default.
- W2053615511 hasConcept C71924100 @default.
- W2053615511 hasConceptScore W2053615511C112705442 @default.
- W2053615511 hasConceptScore W2053615511C126322002 @default.
- W2053615511 hasConceptScore W2053615511C126838900 @default.
- W2053615511 hasConceptScore W2053615511C141071460 @default.
- W2053615511 hasConceptScore W2053615511C146957229 @default.
- W2053615511 hasConceptScore W2053615511C2776232967 @default.
- W2053615511 hasConceptScore W2053615511C2776256026 @default.
- W2053615511 hasConceptScore W2053615511C2776694085 @default.
- W2053615511 hasConceptScore W2053615511C2777714996 @default.
- W2053615511 hasConceptScore W2053615511C2778847313 @default.
- W2053615511 hasConceptScore W2053615511C2779127879 @default.
- W2053615511 hasConceptScore W2053615511C2779634585 @default.
- W2053615511 hasConceptScore W2053615511C42219234 @default.
- W2053615511 hasConceptScore W2053615511C71924100 @default.
- W2053615511 hasIssue "3" @default.
- W2053615511 hasLocation W20536155111 @default.
- W2053615511 hasLocation W20536155112 @default.
- W2053615511 hasOpenAccess W2053615511 @default.
- W2053615511 hasPrimaryLocation W20536155111 @default.
- W2053615511 hasRelatedWork W107489882 @default.
- W2053615511 hasRelatedWork W2352157767 @default.
- W2053615511 hasRelatedWork W2352394200 @default.
- W2053615511 hasRelatedWork W2362599535 @default.
- W2053615511 hasRelatedWork W2368172926 @default.
- W2053615511 hasRelatedWork W2369942198 @default.
- W2053615511 hasRelatedWork W2393204141 @default.
- W2053615511 hasRelatedWork W2397734907 @default.
- W2053615511 hasRelatedWork W2591994030 @default.
- W2053615511 hasRelatedWork W4290251928 @default.
- W2053615511 hasVolume "77" @default.
- W2053615511 isParatext "false" @default.
- W2053615511 isRetracted "false" @default.
- W2053615511 magId "2053615511" @default.
- W2053615511 workType "article" @default.