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• W2053640161 endingPage "1084" @default.
• W2053640161 startingPage "1075" @default.
• W2053640161 abstract "Ten xanthene dyes (XAN) are evaluated for their ability to potentiate the antiviral activity of poly r(A-U) using a human foreskin fibroblast-vesicular stomatitis virus bioassay in which the XAN is combined with 0.2 mM poly r(A-U) to produce a XAN/ribonucleotide ratio of 1/4. Four of the ten XANs tested in this study, rhodamine 123, rhodamine B, rhodamine 6G and sulforhodamine B, enhance the antiviral activity of poly r(A-U) 8- to 15-fold. The interferon-inducing activity of the four active XAN/poly r(A-U) combinations is equal to the sum of the activities of their constituents. These four XANs appear to potentiate the antiviral activity of the poly r(A-U) without superinduction of interferon. The direct viral inactivation study demonstrates that the XANs, poly r(A-U) and the XAN/poly r(A-U) combinations do not inactivate the VSV at concentrations near the 50% effective dose." @default.
• W2053640161 created "2016-06-24" @default.
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• W2053640161 date "1990-12-01" @default.
• W2053640161 modified "2023-10-01" @default.
• W2053640161 title "Potentiation of the antiviral activity of poly r(A-U) by xanthene dyes" @default.
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• W2053640161 doi "https://doi.org/10.1016/0309-1651(90)90015-q" @default.
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