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• W2053642404 startingPage "4965" @default.
• W2053642404 abstract "ABSTRACT Previously, we have characterized feline CD4 + CD25 + T-regulatory (Treg) cells with regard to their immune regulatory properties and ability to support feline immunodeficiency virus (FIV) replication in vitro and in vivo. Our studies showed that while CD4 + CD25 + cells were capable of replicating FIV in the presence of interleukin-2 (IL-2) alone, CD4 + CD25 − cells harbored a latent infection that required a strong mitogenic stimulus to activate virus replication. In the present study, we investigated the mechanisms governing the preferential replication of FIV in highly purified CD4 + CD25 + Treg cells compared to their CD4 + CD25 − counterparts. Studies aimed at elucidating mechanisms regulating infection of these cells revealed that CD4 + CD25 − cells were less susceptible to FIV binding and entry than CD4 + CD25 + cells, which correlated with increased surface expression of FIV coreceptor CXCR4. In addition, the number of CD4 + CD25 + cells that expressed the primary receptor CD134 was greater than for CD4 + CD25 − cells. Although increased permissiveness to FIV infection of CD4 + CD25 − cells following mitogenic stimulation correlated strongly with upregulation of surface CXCR4, it did not correlate with CD134 expression. Further, study of intracellular factors regulating FIV replication revealed that CD4 + CD25 + but not CD4 + CD25 − T cells showed constitutive and IL-2-responsive transactivation of activating transcription factor, CAAT enhancer binding protein, and activating protein 1 transcription factors that are important for FIV replication. These factors were upregulated in CD4 + CD25 − T cells following ConA stimulation, which correlated with FIV replication. This is the first report elucidating the mechanisms that allow for productive lentiviral infection of CD4 + CD25 + Treg cells." @default.
• W2053642404 created "2016-06-24" @default.
• W2053642404 creator A5012620834 @default.
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• W2053642404 date "2005-04-15" @default.
• W2053642404 modified "2023-10-12" @default.
• W2053642404 title "Preferential Feline Immunodeficiency Virus (FIV) Infection of CD4⁺CD25⁺T-Regulatory Cells Correlates both with Surface Expression of CXCR4 and Activation of FIV Long Terminal Repeat Binding Cellular Transcriptional Factors" @default.
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• W2053642404 doi "https://doi.org/10.1128/jvi.79.8.4965-4976.2005" @default.
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