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- W2053644130 abstract "OBJECTIVES: Andrographis paniculatahasin vitroinhibitory activity against TNF-α, IL-1β and NF-κB. A pilot study ofA. paniculataextract (HMPL-004) suggested similar efficacy to mesalamine for ulcerative colitis. METHODS: A randomized, double-blind, placebo-controlled trial evaluated the efficacy ofA. paniculataextract (HMPL-004) in 224 adults with mild-to-moderate ulcerative colitis. Patients were randomized toA. paniculataextract (HMPL-004) 1,200 mg or 1,800 mg daily or placebo for 8 weeks. RESULTS: In total, 45 and 60% of patients receivingA. paniculata1,200 mg and 1,800 mg daily, respectively, were in clinical response at week 8, compared with 40% of those who received placebo (P=0.5924 for 1,200 mg vs. placebo andP=0.0183 for 1,800 mg vs. placebo). In all, 34 and 38% of patients receivingA. paniculata1,200 mg and 1,800 mg daily, respectively, were in clinical remission at week 8, compared with 25% of those who received placebo (P=0.2582 for 1,200 mg vs. placebo andP=0.1011 for 1,800 mg vs. placebo). Adverse events developed in 60 and 53% of patients in theA. paniculata1,200 mg and 1,800 mg daily groups, respectively, and 60% in the placebo group. CONCLUSIONS: Patients with mildly to moderately active ulcerative colitis treated withA. paniculataextract (HMPL-004) at a dose of 1,800 mg daily were more likely to achieve clinical response than those receiving placebo." @default.
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- W2053644130 date "2013-01-01" @default.
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- W2053644130 title "Andrographis paniculata Extract (HMPL-004) for Active Ulcerative Colitis" @default.
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- W2053644130 doi "https://doi.org/10.1038/ajg.2012.340" @default.
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